A5103967629- Quinazolinone synthesis and applications
- Chronic Myeloid Leukemia Treatments
- Click Chemistry and Applications
Yıldız Technical University
2021
Abstract Different derivatives of imatinib, the first targeted BCR-ABL fusion tyrosine kinase inhibitor, were synthesized by a 3-step reaction method. Firstly, benzamide derivative was obtained then aryl piperazine groups or morpholine linked S N 2 reaction. Lastly, palladium catalyzed C-N coupling conducted with hetaryl amine groups. The structures new compounds characterized spectroscopic methods. For quantitative evaluation biological activity compounds, MTT assays performed, where four...
Different derivatives of imatinib were synthesized by a 3-step reaction method. The structures the new compounds characterized spectroscopic methods. For quantitative evaluation biological activity compounds, MTT assays performed, where four BCR-ABL negative leukemic cell lines (Jurkat, Reh, Nalm-6 and Molt-4), one positive line (K562), non-leukemic (Hek293T) incubated with various concentrations derivatives. Although was specifically designed for protein, our results showed that it also...