In reliability analysis for the practical engineering problems with time-consuming model, it has become an important challenge that how to obtain accurate assessment a minimum number of calls. order reduce computational cost, this paper develops new sequential surrogate method combining adaptive kriging and Markov chain Monte Carlo simulation novel learning strategy analysis. The proposed is named AK-MCMC, which takes full advantage classification feature based on models, can efficiently...

The design requirement of a mechanical system with motion mechanisms is to ensure the successful implementation its functions. Aiming at characteristics mechanisms, reliability allocation methodology proposed. Since plays an important role in decomposition extended map functions subsystems. Combined analytic hierarchy process model, subsystem contribution factor developed. For nondestructive fault events that have significant impact on are considered potential improvement factor. To assist...

Retinoic acid receptor α (RARα), a member of family the nuclear retinoic receptors (RARs), plays an essential role in various chronic kidney diseases (CKD). Renal tubular epithelial to mesenchymal transition (EMT) is common mechanism progression renal interstitial fibrosis (RIF). Hypoxia has been extensively considered as one major inducers EMT. However, effects RARα on hypoxia-induced EMT have not yet described so far. The aim present study was explore roles and potential mechanisms cells...

Variable camber wing technology stands out as the most promising morphing currently available in green aviation. Despite ongoing advancements smart materials and compliant structures, they still fall short terms of driving force, power, speed, rendering mechanical structures based on kinematics preferred choice for large long-range civilian aircraft. In line with this principle, paper introduces a linkage-based variable trailing edge design approach. Covering coordinated design, internal...

Systems in engineering usually not only have multiple states but also may be required to fulfill several functions, meaning the system has performance variables a specific state. In multi-performance multi-state weighted K−-out-of-n system, consists of components for completing its different functions. As this is more complicated than general k-out-of-n reliability evaluation time-consuming. A recursive approach developed evaluate efficiently, and comparison with existing carried out various...

In this paper, a new reliability method for load-sharing parallel systems with dependent components that share the workload equally before and after some have failed is studied. working process of system, failure components, surviving original system higher loads. The states all are dependent. behavior component impacts strength degradation remaining components. For one works whole works, which means largest initial works. Firstly, we use equivalent theory to get fail. Then, stress-strength...

To detect disease-causing mutations in a patient with hereditary elliptocytosis.Sodium dodecyl sulfate polyacrylamide gel electropheresis (SDS-PAGE) was used to identify the type of erythrocyte membrane protein defect. Potential exons and adjacent introns relevant genes were analyzed by Sanger sequencing.SDS-PAGE has failed any difference between healthy controls. However, sequencing detected three SPTA1 gene patient, which included c.5077A>C (p.Lys1693Gln) missense mutation exon 36,...

Failure boundaries are always far away from the center of design space variables for low failure probability problems. In order to make full use samples, a partitioning method experimental levels is proposed improving general experiments in this paper. The implemented by non-uniformly according density function variables, which leads wide interval adjacent at high value, while narrow one low. translational propagation latin hypercube was improved using method. To validate practicability and...

The distribution and parameters of the random variables is an important part conventional reliability analysis methods, such as Monte Carlo method, which should be known fist before using these but it often hard or impossible to obtain. Model-free sampling technique puts forward a method get variables, accuracy extended sample generated by not enough. This paper presented improved model-free technique, based on Bootstrap increase decrease iteration times. In this selection initial points...

A total of 130 anvolatory infertile outpatients were divided randomly into 4 groups LE1 (letrozole 2.5 mg, n=45), LE2 5 n=30), CC1 (clomiphene citrate 50 n=35) and CC2 100 n=20). The treatments started at day menstruation lasted for days. size number ovarian follicles thickness endometrium all measured starting from 10 menstruation.8 000-10 000 units human chorionic gonadotropin (hCG) was injected when ovary mature. And blood estradiol (E2 ) the same day. Ovulation, pregnancy adverse...