A5082156082- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- Microwave-Assisted Synthesis and Applications
- Click Chemistry and Applications
- Synthesis and Reactions of Organic Compounds
- Synthesis and Characterization of Pyrroles
- Synthesis of Organic Compounds
- Malaria Research and Control
- Chemical synthesis and pharmacological studies
- Synthesis and Reactivity of Heterocycles
- HIV/AIDS drug development and treatment
- Synthesis of heterocyclic compounds
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Fluorine in Organic Chemistry
- Chemical Synthesis and Reactions
- Synthetic Organic Chemistry Methods
- Quinazolinone synthesis and applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Crystal structures of chemical compounds
Institute for Single Crystals
2011-2024
National Academy of Sciences of Ukraine
2007-2024
University of South Florida
2021
University of Zurich
2021
University of Konstanz
2008
Abstract Three‐component reactions involving 3‐amino‐1,2,4‐triazole, aldehydes, including salicylic and pyruvic acids were studied in detail. The reaction pathway products of the heterocyclizations could be changed by variation parameters. broad antimicrobial activity was also studied. Compound 9d showed specific anti‐influenza virus (A/H1N1) activity, with an IC 50 0.57 μ M a CC >100 .
Three-component condensation of pyruvic acid with aromatic aldehydes and some aminoazoles was developed as a procedure for the synthesis 5-aryl-5,8-dihydroazolo[1,5-a]pyrimidine-7-carboxylic acids. An influence solvent type on composition reaction products found. The structures compounds obtained were proved by 1H 13C NMR spectroscopy, NOE experiments, X-ray analysis.
Preclinical and clinical development of numerous small molecules is prevented by their poor aqueous solubility, limited absorption, oral bioavailability. Herein, we disclose a general prodrug approach that converts promising lead compounds into aminoalkoxycarbonyloxymethyl (amino AOCOM) ether-substituted analogues display significantly improved solubility enhanced bioavailability, restoring key requirements typical for drug candidate profiles. The completely independent biotransformations...
Four-component reactions of 3-amino-1,2,4-triazole or 5-amino-1 H -pyrazole-4-carbonitrile with aromatic aldehydes and pyruvic acid its esters under ultrasonication were studied. Unusual for such a reaction type, cascade elementary stages led to the formation 7-azolylaminotetrahydroazolo[1,5- ]pyrimidines.
The present review includes the analysis of known literature data concerning linear and multicomponent heterocyclizations involving pyruvic acids aminoazoles. In particular, demonstrates approaches to control regio- chemoselectivity these types treatments their application solve matters Diversity Oriented Synthesis.
The reactivity of 1-(4-chlorophenyl)-3,5-diamino-1,2,4-triazole in multicomponent reactions with pyruvic acid and aldehydes two-component arylidenepyruvic was studied. unusual direction these treatments leading to the formation unprecedented 3-[5-amino-1-(4-chlorophenyl)-1,2,4-triazol-3-ylamino]-5-arylfuran-2-ones instead triazolopyrimidine or triazolylpyrrolone derivatives found discussed.
Substituted 1 H -pyrazolo[3,4- b ]pyridine-4- and ]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in convergent versatile manner using diversity generation strategies: combination of two reactions conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine peptidomimetic moieties with four points introduced from readily available starting materials including scaffold diversity. A small focused...
By one-pot four- and three-component Ugi reactions involving convertible isocyanides unexplored pyrrole-containing β-chlorovinylaldehyde, a small library of 20 bisamides with unusual behavior in post-Ugi transformations was prepared characterized. Surprisingly, well-documented approach to obtain peptide-containing carboxylic acids through acid hydrolysis the isocyanide moiety proceeded an unexpected manner our case, leading formation derivatives amides heterylidenepyruvic acid. An optimized...
The title compound, C 36 H 37 ClN 4 O 7 ·CH 3 OH, which crystallizes as a methanol solvate, may possess biological activity, is inherent for natural peptide or protein. In the crystal, molecules of compound form hydrogen-bonded tetramers with solvate acting bridges result O—H...O and N—H...O intermolecular hydrogen bonds. Hirshfeld surface analysis was used to study different types interactions whose contributions are: H...H = 53.8%, O...H/H...O 19.0%, C...H/H...C 14.8%, Cl...H/H...Cl 5.3%,...
The multicomponent reactions of 5-amino-3-methylthio-1,2,4-triazole with aromatic aldehydes and pyruvic acid were studied using conventional thermal heating ultrasonic activation at room temperature. Under heating, dihydrotriazolopyrimidine derivatives formed in both two- three-component treatments. In the case activation, reaction led to formation 7-hydroxytetrahydrotriazolopyrimidines.
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Abstract The three‐component reactions are carried out under thermodynamic control (reflux or microwave heating) and kinetic (ultrasonication).
Abstract Introduction of an aryl substituent in position 1 the aminotriazole (I) affects direction three‐component reaction to produce furanones type (IV) instead expected triazolopyrimidine or triazolylpyrrolone structures.