A5031828177- Metabolism and Genetic Disorders
- Pancreatic function and diabetes
- Diet and metabolism studies
- Folate and B Vitamins Research
- Mitochondrial Function and Pathology
- Virus-based gene therapy research
- Blind Source Separation Techniques
- RNA Interference and Gene Delivery
- ECG Monitoring and Analysis
- Neonatal Health and Biochemistry
- Adolescent and Pediatric Healthcare
- Genomics and Rare Diseases
- Hydrogels: synthesis, properties, applications
- Animal Genetics and Reproduction
- EEG and Brain-Computer Interfaces
- Electrospun Nanofibers in Biomedical Applications
- Plant and animal studies
- Biochemical and Molecular Research
- Chaos control and synchronization
- Delphi Technique in Research
- Heart Rate Variability and Autonomic Control
- Metabolomics and Mass Spectrometry Studies
- Insect and Pesticide Research
- Tissue Engineering and Regenerative Medicine
- Complex Systems and Time Series Analysis
Hamilton Health Sciences
2007-2024
Health Sciences Centre
2006-2024
University of Ottawa
2015-2024
McMaster Children's Hospital
2022-2024
McMaster University
2010-2023
Hamilton Regional Laboratory Medicine Program
2006-2023
Massey University
2014-2023
Université de Sherbrooke
2021
Indiana University – Purdue University Indianapolis
2020
McMaster University Medical Centre
2006-2018
Management of phenylketonuria (PKU) requires lifelong restriction phenylalanine (Phe) intake using specialized medical foods to prevent neurocognitive impairment in affected patients. However, dietary adherence is challenging maintain while ensuring adequate nutrition, which can lead sub-optimal clinical outcomes. Metabolomics offers a systematic approach identify new biomarkers disease progression PKU when urine as surrogate for blood specimens that more accurate than self-reported diet...
1. Two experiments were conducted to determine the apparent metabolisable energy (AME) and standardised amino acid digestibility coefficients (SIDC) of black soldier fly larvae (BSFL) for broiler chickens.2. The BSFL contained, on a g/kg dry matter basis: crude protein, 486; fat, 320; ash, 58.5; neutral detergent fibre, 181; calcium, 6.8 phosphorus, 9.1.3. In Experiment 1, an AME assay was performed wherein broilers fed two experimental diets (a maize-soy basal diet test containing 250 BSFL)...
Abstract Introduction Behavioral variant frontotemporal dementia (bvFTD) may present sporadically or due to an autosomal dominant mutation. Characterization of both forms will improve understanding the generalizability assessments and treatments. Methods A total 135 sporadic (s‐bvFTD; mean age 63.3 years; 34% female) 99 familial (f‐bvFTD; 59.9; 48% bvFTD participants were identified. f‐bvFTD cases included 43 with known presumed chromosome 9 open reading frame 72 ( C9orf72 ) gene expansions,...
Self-cross-linkable polyelectrolyte pairs comprised of poly(methacrylic acid, sodium salt-co-2-[methacryloyloxy]ethyl acetoacetate) (70:30 mol ratio, A70) and poly-l-lysine are incorporated into CaAlg beads to form either a covalently cross-linked shell or core-cross-linked bead. In both cases the reactive polyanion is added solution alginate that may contain live cells dropped calcium chloride gelling bath. Subsequent exposure (15−30 kDa) leads formation shell, while lower molecular weight...
Summary Aims Limited joint mobility (LJM) in the foot has not been assessed adolescents with Type 1 diabetes mellitus (DM) but is associated neuropathic ulceration adults. This study was designed to determine presence of LJM DM and its association microvascular disease. Methods The hands, feet hips were examined 302 diabetic 51 nondiabetic controls (aged 11.5–20 years). defined as less than fifth percent reference for controls. Results Reduced motion found 35% at subtalar (ST) joint, 18%...
Self-cross-linking polyelectrolytes are used to strengthen the surface of calcium alginate beads for cell encapsulation. Poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride), containing 30 mol % 2-aminoethyl methacrylate, and poly(sodium methacrylate), 2-(methacryloyloxy)ethyl acetoacetate, were prepared by radical polymerization. Sequential deposition these on films or led a shell consisting covalently cross-linked polyelectrolyte complex that resisted osmotic pressure changes as well...
Improvements in health care for children with chronic diseases must be informed by research that emphasizes outcomes of importance to patients and families. To support a program the field rare inborn errors metabolism (IEM), we conducted broad scoping review primary studies that: (i) focused on pediatric similar IEM etiology or manifestations complexity management; (ii) reported patient- and/or family-oriented outcomes; (iii) measured these using self-administered tools.We developed...
BACKGROUND Evidence to guide treatment of pediatric medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency and phenylketonuria (PKU) is fragmented because large variability in outcome selection measurement. Our goal was develop core sets (COSs) for these diseases facilitate meaningful future evidence generation enhance the capacity compare synthesize findings across studies. METHODS Parents and/or caregivers, health professionals, policy advisors completed a Delphi survey participated...
Abstract Microcapsules bearing a covalently cross‐linked coating have been developed for cellular gene therapy as an improvement on alginate‐poly( L ‐lysine)‐alginate (APA) microcapsules that only ionic cross‐linking. In this study, two mutually reactive polyelectrolytes, polycation (designated C70), poly([2‐(methacryloyloxy)ethyl]trimethylammonium chloride‐ co ‐2‐aminoethyl methacrylate hydrochloride) and polyanion A70), poly(sodium methacrylate‐ ‐2‐(methacryloyloxy)ethyl acetoacetate),...
Abstract: The urea-cycle functions to facilitate ammonia excretion, a disruption of which results in the accumulation toxic metabolites. neurological outcome neonatal-onset defects (UCDs) is poor, and there are no good predictors prognosis beyond levels at presentation. role neuroimaging UCDs unclear. We describe magnetic resonance imaging (MRI) findings two patients with (argininosuccinic aciduria citrullinemia) presentation 2-year follow-up, present review literature on this age-group....
Sprint interval training (SIT), repeated bouts of high-intensity exercise, improves skeletal muscle oxidative capacity and exercise performance. β-alanine (β-ALA) supplementation has been shown to enhance performance, which led us hypothesize that chronic β-ALA would augment work during SIT training-induced adaptations in Twenty-four active but untrained men (23 ± 2 yr; VO2peak = 50 6 mL · kg(-1) min(-1)) ingested 3.2 g/day or a placebo (PLA) for total 10 weeks (n 12 per group). Following 4...
Abstract One method of nonviral‐based gene therapy is to implant microencapsulated nonautologous cells genetically engineered secrete the desired products. Encapsulating within a biocompatible permselective hydrogel, such as alginate‐poly‐L‐lysine‐alginate (APA), protects foreign from host immune system while allowing diffusion nutrients and therapeutic An important consideration which kind best candidate for long‐term implantation. Our previous work has shown that proliferation...
Polyanions based on poly(methyl vinyl ether-alt-maleic acid) were investigated as materials for cell encapsulation. These water-soluble polyanions having molecular masses ranging from 20 to 1980 kDa prepared by functionalization of anhydride) with 5-aminofluorescein and/or α-methoxy-ω-amino-poly(ethylene glycol), followed base hydrolysis the residual anhydride groups form corresponding ether-alt-sodium maleate). Their potential replace alginate both in core and, particular, outer shell...
Abstract The New Zealand tea tree Leptospermun scoparium (mānuka) is widely known for the antimicrobial properties of its honey. Mānuka native to Zealand, growing in a range environments, including Central Volcanic Plateau North Island, where it currently threatened by spread exotic invasive weeds such as heather ( Calluna vulgaris ) and Scotch broom Cytisus scoparius ). Here, we characterise first time aboveground volatile organic compounds (VOCs) produced mānuka this area, during summer...