A5059938457- Gene Regulatory Network Analysis
- Microbial Metabolic Engineering and Bioproduction
- Genetics, Bioinformatics, and Biomedical Research
- Bioinformatics and Genomic Networks
- Protein Structure and Dynamics
- Philosophy, Sociology, Political Theory
- Social Sciences and Governance
- Child Therapy and Development
- Bacterial Genetics and Biotechnology
- Education, sociology, and vocational training
- Coaching Methods and Impact
- RNA and protein synthesis mechanisms
- Microbial Natural Products and Biosynthesis
- Origins and Evolution of Life
- Gene expression and cancer classification
- Psychology, Coaching, and Therapy
- Complex Network Analysis Techniques
- Advanced biosensing and bioanalysis techniques
- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Photoreceptor and optogenetics research
- Simulation Techniques and Applications
- Healthcare Systems and Practices
Laboratoire de Recherche en Informatique
2009-2020
Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic
2010-2020
Centre National de la Recherche Scientifique
2008-2020
Université Paris-Saclay
2011-2020
Holy Cross Hospital
2019
Université Paris-Sud
2008-2018
École Polytechnique
2010-2013
Institut national de recherche en informatique et en automatique
2012
Epigenomics (Germany)
2011
Université Paris Cité
2011
Significance What new properties may result from collective cell behavior, and how these emerging capabilities influence shaping function of tissues, in health disease? Here, we explored questions the context epithelial branching morphogenesis. We show experimentally that, whereas individual mammary cells are incapable sensing extremely weak gradients a growth factor, cellular collectives organotypic cultures exhibit reliable, gradient-driven, directional growth. This underscores critical...
There is extensive evidence for the interaction of metabolic enzymes with eukaryotic cytoskeleton. The significance these interactions far from clear. In cytoskeletal integrative sensor hypothesis presented here, cytoskeleton senses and integrates general activity cell. This depends on binding to and, depending nature enzyme, this may occur if enzyme either active or inactive but not both. enzyme-binding further proposed stabilize microtubules microfilaments alter rates GTP ATP hydrolysis...
Biological systems have evolved efficient sensing and decision-making mechanisms to maximize fitness in changing molecular environments. Synthetic biologists exploited these capabilities engineer control on information energy processing living cells. While engineered organisms pose important technological ethical challenges, de novo assembly of non-living biomolecular devices could offer promising avenues toward various real-world applications. However, assembling biochemical parts into...
Abstract Background The advantages of grouping enzymes into metabolons and higher order structures have long been debated. To quantify these advantages, we developed a stochastic automaton that allows experiments to be performed in virtual bacterium with both membrane cytoplasm. We investigated the general case transport metabolism as inspired by phosphoenolpyruvate:sugar phosphotransferase system (PTS) for glucose importation glycolysis. Results show PTS glycolytic can increase production...
One of the main characteristics complex systems is that interrelations between entities composing system are not permanently established but evolve along time. As opposed to complicated systems, structure also in a dynamic organizational process. When studying self-organization and emergent phenomena must therefore be taken into account studied carefully. In this paper, we propose provide tools order automatically detect characterize occurring agent-based simulations. To end, consider...
At all levels of Life, systems evolve on the 'scales equilibria'. level bacteria, individual cell must favor one two opposing strategies and either take risks to grow or avoid survive. It has been proposed in Dualism hypothesis that growth survival depend non-equilibrium equilibrium hyperstructures, respectively. further cycle itself is way cells manage balance ratios these types hyperstructure so as achieve compromise solution living scales. Here, we attempt re-interpret a major event,...
A fundamental problem in biochemistry is that of the nature coordination between and within metabolic signalling pathways. It conceivable this might be assured by what we term functioning-dependent structures (FDSs), namely those assemblies proteins associate with one another when performing tasks disassociate no longer them. To investigate a role for FDSs, have studied numerically steady-state kinetics model system two sequential monomeric enzymes, E(1) E(2). Our calculations show such FDSs...
Synthetic biology studies how to design and construct biological systems with functions that do not exist in nature. Biochemical networks, although easier control, have been used less frequently than genetic networks as a base build synthetic system. To date, no clear engineering principles such cell-free biochemical networks.We describe methodology for the construction of based on three main steps: design, simulation experimental validation. We developed BioNetCAD help users go through...
Abstract Collective cell responses to exogenous cues depend on cell-cell interactions. In principle, these can result in enhanced sensitivity weak and noisy stimuli. However, this has not yet been shown experimentally, and, little is known about how multicellular signal processing modulates single extracellular signaling inputs, including those guiding complex changes the tissue form function. Here we explored if communication enhance ability of ensembles sense respond gradients chemotactic...
How a cell coordinates its thousands of different constituents to achieve coherent – but phenotypes is far from fully understood. It clear though that daughter cells with can be generated by the cycle, which comprises events chromosome replication, segregation and division. In line this, recent experiments are consistent an intimate relationship in bacteria between speed replication at fork(s) metabolism. The process progressively changes copy number genes sites linear order. This raises...
This paper describes a method to obtain in certain sense the best of two well known simulation approaches: Stochastic chemical reactions and Entity-centered (multi-agents) systems. The stochastic algorithm its enhanced versions are adapted simulate behaviour stirred mixture reactants when spatial localisation is not relevant; Conversely, entity-centered methods, causes consequences due handled. In terms computational efficiency, SSA methods limited by number amount reactants, whereas it...
ABSTRACT Esophageal squamous papilloma is a rare endoscopic finding, and esophageal papillomatosis (ESP) considered exceptionally rare, with only limited number of cases reported to date. There paucity literature about the management these lesions, it remains largely controversial. We report 61-year-old man who presented for treatment ESP detected during evaluation heartburn. Given potential risk malignant transformation, decision was made proceed spray cryoablation, requiring total 3...
Many methods have been used to model epidemic spreading. They include ordinary differential equation systems for globally homogeneous environments and partial take into account spatial localisation inhomogeneity. Stochastic equations the inherent stochasticity of spreading processes. In our case study, we wanted numbers individuals in different states disease, their locations country. Among many existing own variant well known Gillespie stochastic algorithm, along with sub-volumes method...
It is sometimes speculated that the equivalent of polymerase chain reaction might be developed for identification peptides, proteins or other molecules. In general, though, it believed there can no way to amplify targets such as proteins. Natural amplification systems do, however, exist in case certain autoinducer bacteria. Here, we outline a possible, generic method, mimic reaction, obtaining peptides with 3-D structures structure their targets. These would include variety molecules,...