A5100391635- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Facial Rejuvenation and Surgery Techniques
- Allergic Rhinitis and Sensitization
- Nasolacrimal Duct Obstruction Treatments
- Ophthalmology and Eye Disorders
- Retinopathy of Prematurity Studies
- Ophthalmology and Visual Impairment Studies
- Signaling Pathways in Disease
- Inflammatory mediators and NSAID effects
- Retinal Diseases and Treatments
- Photochromic and Fluorescence Chemistry
- Olfactory and Sensory Function Studies
- MicroRNA in disease regulation
- Cardiac Fibrosis and Remodeling
- Dermatology and Skin Diseases
- Eicosanoids and Hypertension Pharmacology
- Connexins and lens biology
- Fatty Acid Research and Health
Wuhan University
2008-2025
Zhongnan Hospital of Wuhan University
2008-2025
Ningbo University
2025
University of Nottingham Ningbo China
2025
Guangzhou Medical University
2025
National Natural Science Foundation of China
2023
Zero to Three
2023
Sun Yat-sen University
2021-2022
Massachusetts Eye and Ear Infirmary
2017-2019
Harvard University
2017-2019
Type 2 diabetes mellitus (T2DM) exhibits a bidirectional relationship with periodontitis, wherein each condition influences the progression of other. Arachidonic acid (AA) exerts an anti-diabetic effect, while showing protective effect by regulating inflammatory response independently its metabolites. However, impact on periodontitis T2DM remains poorly understood. The mouse model was established combining high-sugar and high-fat diet streptozotocin injection, followed silk ligation to...
Purpose: Investigators have discovered that topical antiglaucoma drugs may induce meibomian gland dysfunction. This response contribute to the dry eye disease commonly found in patients with glaucoma taking such medications. We hypothesize drug action involves a direct effect on human epithelial cells (HMGECs). To test this hypothesis, we examined influence of drugs, pilocarpine and timolol, morphology, survival, proliferation, differentiation HMGECs. Methods: Immortalized (I) HMGECs (n =...
The purpose of this study is to establish the short tandem repeat (STR) profiles several human cell lines commonly used in ocular surface research.Independently DNA was extracted from multiple passages three corneal epithelial lines, two conjunctival and one meibomian gland line, different laboratories actively involved research. samples were then subjected STR analysis on a fee-for-service basis an academic setting data compared against that available databases.The for cells among studied...
Abstract Glucocorticoid use may cause elevated intraocular pressure, leading to the development of glucocorticoid‐induced glaucoma (GIG). However, mechanism GIG remains incompletely understood. In this study, we subjected primary human trabecular meshwork cells (TMCs) and mice dexamethasone treatment mimic glucocorticoid exposure. The myofibroblast transdifferentiation TMCs was observed in cellular mouse models, as well mesh specimens. This demonstrated by cytoskeletal reorganization,...
Purpose: To establish an environment-induced dry eye model in rabbits using a controlled drying system (CDS). Methods: Rabbits were randomly divided into two groups. The the group housed CDS, which relative humidity, airflow, and temperature at 22% ± 4%, 3 to 4 m/s, 23°C 25°C for 14 days. control normal environment same time. A Schirmer test, fluorescein staining, lissamine green staining performed. On day 14, eyeballs lacrimal glands processed evaluating corneal epithelial thickness,...
Background: A compelling feature of dry eye disease is that it occurs predominantly in women. We hypothesize this female prevalence linked to sex-related differences the meibomian gland (MG). This plays a critical role maintaining tear film, and its dysfunction major cause disease. To understand factors underlie MG sexual dimorphism promote women, we seek identify an optimal model for human MG. Our goal was determine whether murine such model. Toward end, examined sex gene expression are...
Extracellular matrix (ECM) is a key component of the stem cell local microenvironment. Our study aims to explore periglandular distribution major components ECM in Meibomian gland (MG). Human eyelids and mouse were collected processed for immunofluorescence staining. MG tissues stained positive collagen IV α1, α2, α5, α6 around acini duct, but negative α3 α4. The same subunits as early postnatal day 15. Laminin laminin β1 perlecan regions surrounding acinar/ductal junction human MG, not...
Dry eye disease (DED) is a multifactorial with an incidence of approximately 50% worldwide. DED seriously affects quality life and work. The prevalence environmental (eDED) ranges from 35 to 48%. Conjunctival fluid secretion dysfunction may be one the major causes DED. Notably, Cl- flux corresponds conjunctival could affected by ATP. Both cystic fibrosis transmembrane conductance regulator (CFTR) Ca2+-activated channel (CaCC) are channels involved in epithelial secretion. increased...
Objective: To determine whether fibroblast growth factor receptor (FGFR)-targeting drug could impact human meibomian gland. Methods: We followed up with three patients who were using pemigatinib for 4 to 10 weeks. The evaluated their ocular surface disease index, best-corrected visual acuity, Schirmer test, cornea staining, meibum expressibility score, tear meniscus height, noninvasive film breakup time, and gland area. distribution of the FGFR family, FGF7, FGF10 by immunofluorescence...