A5035140543- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Neonatal and fetal brain pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Vestibular and auditory disorders
- Nerve injury and regeneration
- Barrier Structure and Function Studies
- Cerebrospinal fluid and hydrocephalus
- Neuroscience and Neural Engineering
- Neuroscience of respiration and sleep
- Advanced Neuroimaging Techniques and Applications
- Ophthalmology and Eye Disorders
- Transcranial Magnetic Stimulation Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neural dynamics and brain function
- Neurological disorders and treatments
- Hemispheric Asymmetry in Neuroscience
- Functional Brain Connectivity Studies
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Catalytic Cross-Coupling Reactions
- Axon Guidance and Neuronal Signaling
- Catalytic C–H Functionalization Methods
- Mitochondrial Function and Pathology
University of Wisconsin–Madison
2023-2025
California State University Los Angeles
2020-2021
University of California, Irvine
2019
University of Missouri
2017
Loyola University Chicago
1994-2006
University of Southern Denmark
2003
University of Chicago
1977-1998
Loyola University Medical Center
1977-1996
Montreal General Hospital
1990
Aarhus University
1987-1988
Metal-organic frameworks (MOFs) are excellent catalytic materials for the hydrolytic degradation of nerve agents and their simulants. However, most MOF-based hydrolysis catalysts to date reliant on liquid water media buffered by a volatile base. To overcome this practical limitation, we developed simple feasible strategy synthesize MOF composites that structurally mimic phosphotriesterase's active site as well its ligated histidine residues. By incorporating imidazole derivative into pores...
Neuronal death due to ischemic stroke results in permanent deficits sensory, language, and motor functions. The growth-restrictive environment of the adult central nervous system (CNS) is an obstacle functional recovery after other CNS injuries. In this regard, Nogo-A a potent neurite growth-inhibitory protein known restrict neuronal plasticity adults. Previously, we have found that treatment with monoclonal antibody (mAb) IN-1 neutralize immediately enhanced cortico-efferent skilled...
Abstract Retrograde transport of horseradish peroxidase (HRP) was used to define the origin afferents inferior olivary complex (IOC) in rats. Using both ventral and dorsal surgical approaches brainstem, HRP injected into IOC through a micropipette affixed tip 1‐μl Hamilton syringe. After 2‐day postoperative survival, animals were sacrificed by transcardiac perfusion with 1% paraformaldehyde‐1.25% gluteraldehyde solution, brains processed according DeOlmos protocol (1977), using o‐dianisidine...
Abstract The normal distribution pattern of cerebellar efferents was determined using the Fink‐Heimer technique in adult rats that sustained stereotaxic transection superior peduncle. This found to be essentially similar earlier studies and corroborated more recent reports projections pontine gray inferior olivary nuclei. Comparisons were made a second group animals underwent neonatal hemicerebellectomy addition contralateral Abnormal ipsilateral red nucleus ventral thalamus observed...
Melatonin is a pineal hormone that regulates the human cycle of sleep and wakefulness. Plasma melatonin levels were investigated in patients with obstructive apnoea syndrome (OSAS). In total, 20 OSAS 11 healthy controls studied. tested twice: on night diagnostic polysomnography continuous positive airway pressure (CPAP) titration. Controls one occasion. determined at 23:00 h (light period), 02:00 (dark period) 06:00 control subjects using radioimmunoassay method. The showed nocturnal peak...
Reactions that cleave C–C bonds and enable functionalization at both carbon sites are powerful strategic tools in synthetic chemistry. Stereodefined cyclopropyl ketones have become readily available would be an ideal source of 3-carbon fragments, but general approaches to net activation/difunctionalization unknown. Herein, we demonstrate the cross-coupling with organozinc reagents chlorotrimethylsilane form 1,3-difunctionalized, ring-opened products. A combination experimental theoretical...
Abstract The distribution of corticopontine projections was studied, primarily with the Fink‐Heimer technique, in adult rats which at 2‐3 days age had sustained unilateral sensorimotor (SMC) or occipital (OC) cortical lesions and animals that received neonatal hemicerebellar (HCb) singly combination SMC OC lesions. Neonatal left HCb induced an anomalous increase crossed (SMP) originating from right SMC. This appeared more dense after as compared to cerebellar those receiving combined plus No...
The intracerebral injection of N-methyl-D-aspartate (NMDA) has been proposed as a model for hypoxic-ischemic insult in the immature brain. In this light, aim study was to describe time course microglial reaction areas undergoing primary degeneration at site intracortical NMDA well secondary anterograde and/or retrograde degeneration. Fifty nanomoles were injected sensorimotor cortex 6-day-old rats. After survival times ranging from 10 hours 28 days, cryostat sections stained routine...
Several studies using a variety of animals have reported conflicting evidence concerning the distribution, laterally, and indeed presence ascending projections to pontine nuclei. In an attempt clarify this issue, nuclei from spinal cord, dorsal column nuclei, trigeminal nucleus were investigated with anterograde methods, i.e., Fink-Heimer technique and/or autoradiography, in Long-Evans black-hooded rats. Results revealed that nuclear contralateral gray terminate predominantly two...
Abstract Autoradiographic and axonal degeneration staining techniques were combined in individual animals to study the distribution of corticopontine fibers. In normal animals, forelimb hindlimb motor cortical projections terminated somatotopically within ipsilateral pontine nuclei. Sparse crossed also displayed a somatotopic pattern. After unilateral sensorimotor lesions newborn rats, an increase fibers arising from opposite unablated cortex was observed at maturity. These distributed...