A5101815776- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- AI in cancer detection
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- Adenosine and Purinergic Signaling
- Cancer Immunotherapy and Biomarkers
- Nutrition, Genetics, and Disease
- MicroRNA in disease regulation
- Vascular anomalies and interventions
- Neurosurgical Procedures and Complications
- Esophageal Cancer Research and Treatment
- Vascular Malformations Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- Glioma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Neurofibromatosis and Schwannoma Cases
University of Macau
2021-2024
City University of Macau
2024
Daping Hospital
2024
Army Medical University
2024
Army Medical College
2024
Third People's Hospital of Hangzhou
2024
Second Affiliated Hospital of Zhejiang University
2018-2020
Ningxia Medical University
2018
Ningxia Medical University General Hospital
2018
China Medical University
2010-2017
Abstract Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy among primary liver cancers, with an increasing overall incidence and poor prognosis. The intertumoral intratumoral heterogeneity of ICC makes it difficult to find efficient drug therapies. Therefore, essential identify tumor suppressor genes oncogenes that induce formation progression. Here, we performed CRISPR/Cas9-mediated genome-wide screening in a liver-specific Smad4/Pten knockout mouse model ( Smad4...
Pancreatoduodenectomy (PD) is one of the most important operations in hepatobiliary and pancreatic surgery.To evaluate advantages disadvantages pancreaticojejunostomy (PJ) pancreaticogastrostomy (PG).This meta-analysis was performed using Review Manager 5.3. All clinical randomized controlled trials, which patients underwent PD with pancreatico-digestive tract reconstruction via PJ or PG, were included.The search PubMed, Wanfang Data, EMBASE, Cochrane Library provided 125 citations. After...
Diffuse midline glioma with histone H3‐K27M mutation is a new tumor entity defined by the 2016 WHO Classification of Tumors Central Nervous System. A 51‐year‐old Chinese woman presented neck pain for month. Subsequent MRI revealed an intramedullary neoplasm extending from C5 to C7. Histologically, cellular area was composed primitive, poorly differentiated, small cells scant cytoplasm, nuclear molding, and brisk mitotic activity, exhibiting PNET‐like appearance, while in hypocellular area,...
Cholangiocarcinoma (CC), the most lethal type of liver cancer, remains very difficult to treat due an incomplete understanding cancer initiation and progression mechanisms no effective therapeutic drugs.Thus, identification genomic drivers delineation underlying are urgently needed.Here, we conducted a genome-wide CRISPR-Cas9 screening in liver-specific Smad4/Pten knockout mice (Smad4 co/co ;Pten ;Alb-Cre, abbreviated as SPC), identified 15 putative tumor suppressor genes, including Cullin3...
Pancreatic solitary fibrous tumor (SFT) is a rare neoplasm of intermediate biological potential. So far, only 22 cases have been reported since 1999. All the cases, except one, exhibited benign features. Here, we report first case malignant pancreatic SFT with typical Doege-Potter syndrome, along clinical and pathologic evidence its systemic metastasis.The patient was 48-year-old man 1-year history liver masses refractory hypoglycemia. Increased uptake tracer fluorodeoxyglucose (FDG) found...
Abstract Non-alcoholic fatty liver disease is a chronic abnormality that exhibits high variability and can lead to cancer in advanced stages. Hepatic ablation of SIRT6 results disease, yet the potential mechanism deficiency, particularly relation downstream mediators for NAFLD, remains elusive. Here we identify Serpina12 as key gene regulated by Sirt6 plays crucial function energy homeostasis. Specifically, suppresses expression through histone deacetylation at its promoter region, after...
We evaluated different dose effects of rIL-25 on acute ulcerative colitis. Mice were fed 2.5% dextran sulfate sodium (DSS) for 5 days while infused i.p. with repeated doses (0.2, 0.4 and 0.8 μg) in PBS or only after every 24 h at the same time as start DSS exposure. Clinical, macroscopical microscopical assessment colitis severity survival study was performed. Colonic IL-25 expression production IFN-γ, IL-10 IL-4 also analyzed. At a 0.2 μg, aggravated high mortality, better improvements...
Abstract Purpose Detecting programmed death ligand 1 (PD-L1) expression based on immunohistochemical (IHC) staining is an important guide for the treatment of lung cancer with immune checkpoint inhibitors. However, this method has problems such as high costs, tumor heterogeneity, and subjective differences among pathologists. Therefore, application deep learning models to segment quantitatively predict PD-L1 in digital sections Hematoxylin eosin (H&E) stained squamous cell carcinoma...
<title>Abstract</title> Background Detecting programmed death ligand 1 (PD-L1) expression based on immunohistochemical (IHC) staining is an important guide for the treatment of lung cancer with immune checkpoint inhibitors. However, this method has problems such as high costs, tumor heterogeneity, and subjective differences among pathologists. Therefore, application deep learning models to segment quantitatively predict PD-L1 in digital sections Hematoxylin eosin (H&E) stained squamous...
<title>Abstract</title> Cyclin-dependent kinases 4 and 6 (CDK4/6) regulate cell cycle progression from the G1 to S phase. Recent findings have demonstrated that CDK4/6 inhibition (CDK4/6i) enhances antitumor immunity, as evidenced by increased tumor infiltration of CD8+ T cells, though underlying mechanism remains unclear. Our current study reveals CDK4/6i intratumoral in breast tumors through functional reprogramming tumor-associated macrophages (TAMs), facilitating indirect interactions...
The cryopreservation of cancer tissues to generate frozen libraries is a common practice used worldwide for storing patient samples later applications. However, stored by existing methods cannot be initiating living cell cultures, such as patient-derived tumor organoids (PDOs), which offer great potential personalized treatment. To overcome this challenge, we developed novel procedure culturing PDOs using live tissues. We show that specimens technique maintain their viability and can...
Background Detecting programmed death ligand 1 (PD-L1) expression based on immunohistochemical (IHC) staining is an important guide for the treatment of lung cancer with immune checkpoint inhibitors. However, this method has problems such as high costs, tumor heterogeneity, and subjective differences among pathologists. Therefore, application deep learning models to segment quantitatively predict PD-L1 in digital sections Hematoxylin eosin (H&amp;E) stained squamous cell carcinoma great...
Objective To investigate the relationship of prognosis and expressions HIF-1α, VEGF, EGFR proteins in esophageal squamous cell carcinoma. Methods From January, 2011 to May, 2014, 73 patients with carcinoma were retrospective analyzed for whom they treated Tumor Hospital General Ningxia Medical University. Among them, 36 only underwent radiation therapy, 21 both surgery rest recurrence after local resection tumor radiotherapy. 3D-CRT was adopted 30 patients, while IMRT used 43...
Abstract Background: Hepatectomy and transcatheter arterial chemoembolization (TACE) are common treatments for hepatocellular carcinoma (HCC). Targeting intratumoral lactic acidosis TACE (TILA-TACE) is a new therapeutic approach developed by our team that has superior response rate effective than conventional (cTACE). In this randomized-controlled trial, we will compare the efficacy of hepatectomy TILA-TACE in patients clinically diagnosed with HCC to provide reliable clinical data...
Abstract Background: Hepatic resection and transcatheter arterial chemoembolization (TACE) are common treatments for hepatocellular carcinoma (HCC). Targeting intratumoral lactic acidosis TACE (TILA-TACE) is a new therapeutic approach developed by our team that has superior response rate effective than conventional (cTACE). In this randomized-controlled trial, we will compare the efficacy of hepatic TILA-TACE in patients clinically diagnosed with HCC to provide reliable clinical data...