A5000279301- Cardiac, Anesthesia and Surgical Outcomes
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- COVID-19 and healthcare impacts
- Bone fractures and treatments
- Infectious Diseases and Tuberculosis
- Pleural and Pulmonary Diseases
- Pharmacological Effects and Toxicity Studies
- Enhanced Recovery After Surgery
- SARS-CoV-2 and COVID-19 Research
- Pneumothorax, Barotrauma, Emphysema
- Adipose Tissue and Metabolism
- Pregnancy and preeclampsia studies
- Maternal Mental Health During Pregnancy and Postpartum
- Connective tissue disorders research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Rheumatoid Arthritis Research and Therapies
- Orthopedic Surgery and Rehabilitation
- Respiratory Support and Mechanisms
- Lung Cancer Diagnosis and Treatment
- COVID-19 Impact on Reproduction
- Vaccine Coverage and Hesitancy
- Reconstructive Facial Surgery Techniques
- Hip and Femur Fractures
- Ocular Disorders and Treatments
University of Cambridge
2020-2024
Cambridge University Hospitals NHS Foundation Trust
2021-2022
Institut de Virologie
2021
Addenbrooke's Hospital
2019-2021
Wellcome/MRC Institute of Metabolic Science
2019
Wellcome Trust
2019
Abstract About 5–10% of neurofibromatosis type 1 (NF1) patients exhibit large genomic germline deletions that remove the NF1 gene and its flanking regions. The most frequent deletion is 1.4 Mb, resulting from homologous recombination between two low copy repeats. This “type-1” associated with a severe clinical phenotype in patients, several phenotypic manifestations including learning disability, much earlier development cutaneous neurofibromas, an increased tumour risk, cardiovascular...
A 9-year-old boy presents with a distal radial fracture following fall from playground climbing equipment. Four years previously, subsequent to two episodes of generalised seizures, he was diagnosed epilepsy and prescribed an ongoing long-term treatment sodium valproate which has allowed effective seizure control. You have heard that antiepileptic medications adverse effects on bone health, wonder if should had mineral density (BMD) measurements assess for risk. This critically appraised...
### Clinical bottom line A newborn baby was observed to have a unilateral port-wine stain (PWS) in the distribution of maxillary branch trigeminal nerve on right side face, including lower eyelid. Further examinations, neurological and ophthalmological assessments, were unremarkable patient not routinely followed up for ophthalmic assessment, keeping with hospital guidelines. Twelve years later, presented their optometrist complaining worsening vision eye, secondary glaucoma. As early...
Background: The presentation of a hot swollen joint is common in the emergency department, general practice, rheumatology and orthopedic clinics. There wide set differential diagnoses for joint, thus making it difficult to diagnose manage, especially junior doctors. Initially, pertinent exclude/diagnose medical surgical emergencies. Objective: This paper aims summarize key indications within history, examination investigations order quickly effectively based on original 2006 management...
<h3></h3> At least a third of patients go on to suffer recurrence following first spontaneous pneumothorax. Surgical intervention reduces the risk and has been advocated as primary treatment for But surgery exposes risks anaesthesia in some cases can cause chronic pain. Risk stratification identify those most would help direct appropriate early intervention. Many studies have addressed role thoracic CT identifying individuals at increased recurrence, but consensus whether provides valuable...
Abstract Aim The aim of this study is to investigate whether a disruption proximal and/or distal tibio-fibular joint correlates patient’s function and osteoarthritis. Method Retrospective analysis 44 patients with lower limb bone defects treated by tibial corticotomy distraction osteogenesis was conducted. Analysis x-rays before surgery, immediately post-surgery after frame removal permitted calculations changes in length fibula position relative the tibia at joints. X-rays treatment were...