A5010261787- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Molecular Biology Techniques and Applications
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- Congenital Diaphragmatic Hernia Studies
- Esophageal Cancer Research and Treatment
- Diverticular Disease and Complications
- Congenital Heart Disease Studies
- Anorectal Disease Treatments and Outcomes
- RNA modifications and cancer
- Intestinal Malrotation and Obstruction Disorders
- Stoma care and complications
- Cancer Research and Treatments
- Hernia repair and management
- Chemotherapy-induced cardiotoxicity and mitigation
- Colorectal and Anal Carcinomas
- Pathogenesis and Treatment of Hiccups
- Enhanced Recovery After Surgery
- Advanced Optical Imaging Technologies
- Organ Donation and Transplantation
Iwate Medical University
2015-2025
Uji Hospital
2018-2021
Tokyo Institute of Technology
2007
NTN (Japan)
2000-2001
Terumo (Germany)
2000-2001
Setsunan University
2000-2001
ABSTRACT In Japan, comprehensive genome profiling (CGP) as a companion diagnostic (CDx) has been covered by public insurance since June 2019, but the proportion of patients with cancer who actually received drug therapy based on CGP data is low. present study, we attempted to use starting point for tumor‐informed circulating tumor DNA (ctDNA) monitoring. We retrospectively validated 219 malignant tumors underwent at Iwate Medical University Hospital between October 2019 and April 2023 in...
Objective: This study investigated whether digital polymerase chain reaction (dPCR)-based circulating tumor DNA (ctDNA) monitoring can allow longer intervals between computed tomography (CT) scans during postoperative surveillance of colorectal cancer (CRC). Background: Practical guidelines still recommend intensive CRC using periodical CT and serum carcinoembryonic antigen testing. Methods: The longitudinal dynamics ctDNA for 52 patients with as measured by dPCR probes targeting 87...
Abstract We investigated whether early circulating tumor DNA (ctDNA) changes, measured using digital PCR (dPCR), can predict later chemotherapy responses in esophageal squamous cell cancer (ESCC). compared the dynamics of ctDNA and volumes during 42 ESCC. The accuracy predictions was evaluated by ratio variant allele frequency (post-/pre-ctDNA) total volume (post-/pre-volume) before after an initial cycle a receiver-operating characteristic curve analysis. Total positive negative objective...
Situs inversus totalis (SIT) is a rare congenital condition in which the abdominal and thoracic organs are on opposite sides to their normal anatomic positions. Reports of laparoscopic surgery for colorectal cancer with SIT very few. Due mirror-image transposition vascular abnormalities, patients technically complicated. Therefore, it has been reported as easier left-handed surgeons. This report presents that operative procedures can be conducted usual by changing positions operator...
Fabrication of microlens arrays (see figure) is explored using photoinduced reorientation dye-doped liquid crystals and successive photopolymerization with a single laser beam by selecting suitable photoinitiator. Each in the array exhibits polarization selectivity respect to incident polarized light, can be arranged desired patterns directions.
Circulating tumour DNA (ctDNA) is known as a tumour-specific personalised biomarker, but the mutation-selection criteria from heterogeneous tumours remain challenge.We conducted multiregional sequencing of 42 specimens 14 colorectal 12 patients, including two double-cancer cases, to identify mutational heterogeneity develop ctDNA assays using 175 plasma samples."Founder" mutations, defined mutation that present in all regions binary manner (i.e., or absent), were identified 12/14 tumours. In...
Abstract Purpose Pre-existing hypertension is reportedly a major risk factor for bevacizumab-induced proteinuria. However, few studies have focused on the effects of blood pressure (BP) control proteinuria during bevacizumab treatment. We report retrospective study association between poor BP and developing in patients with colorectal cancer (CRC). Methods Data CRC who received April 2015 March 2022 were retrospectively collected. Patients categorized into two groups based average systolic...
Anastomotic leakage during laparoscopic low anterior resection (Lap-LAR) for rectal cancer remains challenging colorectal surgeons. Firing linear staplers multiple times has been reported as a risk factor iatrogenic anastomotic leakage. Our institute usually performs transection using 2 planned stapler fires followed by anastomosis with the double-stapling technique.Between November 2009 and September 2016, total of 272 consecutive patients underwent Lap-LAR cancer. We inserted 45-mm...
Circulating tumor DNA (ctDNA) is released from cells into blood in advanced cancer patients. Although gene mutations individual tumors can be diverse and heterogenous, ctDNA has the potential to provide comprehensive biomarker information. Here, we performed multi-region sampling (three sites) per resected specimen 10 gastric patients followed by targeted sequencing proteomic profiling using reverse-phase protein arrays. A total of 126 non-synonymous were identified 30 samples tumors. Of...
A 55-year-old-man underwent laparoscopic sigmoidectomy for sigmoid colon cancer. Preoperative barium enema showed a slightly medial displacement of the descending colon, and was quite long. The operative findings that not fused with retroperitoneum shifted to midline left adhered small mesentery right pelvic wall. Thus, diagnosis persistent mesocolon (PDM) made. superior rectal arteries often branch radially from inferior mesenteric artery. shortens, vein is close marginal vessels. By...
Melena is a common symptom of schwannoma the small intestine, rare type tumor. Even more intestine that requires massive blood transfusion due to hemorrhage. Herein, we report such case successfully treated with surgical resection.A 72-year-old woman presented previous hospital melena. The patient was taking antiplatelet drugs for cerebral infarction. had progressive anemia continuous Thus, she needed 12 units packed red cells within 1 week admission. A diagnosis not possible based on...
Background Circulating tumor DNA (ctDNA) test has not yet been an established tool for monitoring cancer. Sensitive, affordable methods should allow frequent ctDNA that can assist in clinical management. Patients and Methods This prospective observational study was conducted a total of 36 patients with Stage I to IV esophageal squamous cell cancer (ESCC) were enrolled between September 1, 2015 February 28, 2018. We investigated whether during treatment followed by routine surveillance...
Abstract Background The prognostic value of the pathological response to preoperative chemoradiotherapy (CRT) in rectal cancer (RC) remains unknown. Objectives We aimed assess predictive CRT that was derived from an evaluation histological findings (whole‐section vs. representative‐section sampling) and attempted determine objective cut‐off for tumor regression grade (TRG). Methods examined association TRG with outcomes (recurrence‐free survival [RFS] overall [OS]) 78 patients RC. Patients...
Few cases of intestinal obstruction after colostomy are caused by internal hernia. Some institutions perform stomas through the extraperitoneal route because some patients experience an hernia outside stoma performed intraperitoneal route.
Bladder injuries that occur during laparoscopic surgery are rare but a serious complication. In particular, patients with urachal remnants have high risk for bladder suprapubic port insertion. We report the case of injury caused by remnant ileocecal resection cecal cancer.
We contrived a color-imaging manner in histodiagnosis of cancer and evaluated its clinical feasibility significance.Cancer was microscopically detected by identifying specific reddish pink fluorescence emitted from cells under blue light irradiation, which based on photodynamic diagnosis (PDD) theory.Aminolevulinic acid (ALA) used to treat the histologic samples.Three different types tumor cell lines were as neoplastic models.In vitro, we ascertained that each treated with ALA-contained...
Terumo Corp., NTN and Setsunan University have been developing an implantable left ventricular assist system (T-ILVAS) featuring a magnetically suspended centrifugal pump (MSCP). Chronic sheep experiments(n=8) using prototype MSCP composed of polycarbonate housing impeller (196ml) already demonstrated nonthrombogenicity, long-term durability, excellent stability the magnetic bearing with longest survivor for up to 864 days. These experimental results strongly suggested that is reliable most...
Abstract Purpose Circulating tumor DNA (ctDNA) analysis has been proposed as an approach for prediction of post-treatment patient outcomes. However, whether a single platform will provide optimal information in all patients or alternatively patient-specific monitoring based on assessment mutations the primary from that remains urgent question. Experimental Design: We conducted multiregional sequencing 42 specimens 14 colorectal tumors (Stage III and more) 12 patients, including two double...
ABSTRACT Objective To evaluate long-term whole blood (WB) storage at room temperature (RT), plasma and peripheral mononuclear cell (PBMC) DNA was collected simultaneously using BD Vacutainer ® CPT TM Mononuclear Cell Preparation Tubes (CPT) Streck Cell-Free Blood Collection (BCT ). Methods Plasma isolated from both types of tubes various time points RT. PBMCs extracted WB stored in BCT. The used to monitor esophageal cancer treatment. Results BCT maintained steady levels for up nine days....