A5031895644- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Genomics, phytochemicals, and oxidative stress
- CAR-T cell therapy research
- Immune Response and Inflammation
- Single-cell and spatial transcriptomics
- Retinoids in leukemia and cellular processes
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Exercise and Physiological Responses
- Noise Effects and Management
- Glutathione Transferases and Polymorphisms
- Health, psychology, and well-being
- Asthma and respiratory diseases
- Organ Transplantation Techniques and Outcomes
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- interferon and immune responses
- Immunotoxicology and immune responses
- Heavy Metal Exposure and Toxicity
Michigan State University
2017-2024
GTx (United States)
2024
Stanford University
2023-2024
Michigan United
2017-2024
Stanford Medicine
2021-2022
Abstract T cells are important for the control of acute myeloid leukemia (AML), a common and often deadly malignancy. We observed that some AML patient samples resistant to killing by human-engineered cytotoxic CD4 + cells. Single-cell RNA-seq primary before after their interaction uncovered transcriptional programs correlate with sensitivity or resistance cell killing. Resistance-associated were enriched in patients poor survival, killing-resistant did not engage vitro. Killing-sensitive...
The purpose of this study was to determine the effect subchronic, oral, low-dose cadmium exposure (32 ppm over 10 weeks) on rat immune system. We found that increased induction IFNγ and IL-10 in T cells activated <italic>ex vivo</italic> after exposure.
Type 1 regulatory T (Tr1) cells are subset of peripherally induced antigen-specific cells. IL-10 signaling has been shown to be indispensable for polarization and function Tr1 However, the transcriptional machinery underlying human cell differentiation is not yet elucidated. To this end, we performed RNA sequencing on ex vivo CD49b + LAG3 We identified transcription factor, BHLHE40, highly expressed in Even though characteristically produce high levels IL-10, found that BHLHE40 represses...
Nuclear factor erythroid 2-related 2 (Nrf2) is a stress-activated transcription that induces variety of cytoprotective genes. Nrf2 also mediates immunosuppressive effects in multiple inflammatory models. Upon activation, dissociates from its repressor protein, Keap1, and translocates to the nucleus where it target The Nrf2-Keap1 interaction disrupted by environmental toxicant chemotherapeutic agent arsenic trioxide (ATO). purpose present study was determine ATO on early events T cell...
Introduction Systemic levels of the anti-inflammatory cytokine interleukin 10 (IL-10) are highest in acetaminophen (APAP)-induced acute liver failure (ALF) patients with poorest prognosis. The mechanistic basis for this counterintuitive finding is not known, as induction IL-10 hypothesized to temper pathological effects immune cell activation. Aberrant production after severe injury could conceivably interfere beneficial, pro-reparative actions cells, such monocytes. Methods To test...
Human adaptive immunity is orchestrated by effector and regulatory T (Treg) cells. Natural Tregs arise in the thymus where they are shaped to recognize self-antigens, while type 1 or Tr1 cells induced from conventional peripheral CD4 + response antigens, such as alloantigens allergens. have been developed a potential therapy for inducing antigen-specific tolerance, because can be rapidly differentiated vitro target antigen. However, epigenetic landscape identity of transcription factors...
Abstract Background and Aims In severe cases of acetaminophen (APAP) overdose, acute liver injury rapidly progresses to failure (ALF), producing life-threatening complications including, hepatic encephalopathy (HE) multi-organ (MOF). Systemic levels interleukin-6 (IL-6) IL-10 are highest in ALF patients with the most poorest prognosis. The mechanistic basis for dysregulation these cytokines, their association outcome ALF, remain poorly defined. Methods To investigate impact IL-6 we used an...
Influenza virus infections have been a persistent threat to society, causing up 650,000 respiratory deaths annually world‐wide. The United States alone suffered 80,000 influenza‐related during the 2017/18 flu season. Although vaccine coverage has increased in U.S., this not correlated with decline or deaths. Accordingly, there is significant interest identification of environmental factors which may contribute influenza burden and/or reduce efficacy. Previous work from our laboratory...
Abstract Objectives We examined the effects of food preservative, tert-Butylhydroquinone (tBHQ), on natural killer (NK) cells when infected with influenza in C57Bl/6 mice. Previously, we found tBHQ to negatively impact splenic NK cell effector function vitro. Therefore, hypothesized that consumption would impair response against a primary virus infection. Methods Female, mice were fed either diet containing 0.0014% or control two weeks prior Mice instilled intranasally 21.78 HAU A/PR/8/34...
<b>Abstract ID 20848</b> <b>Poster Board 24</b> Arsenic is a naturally occurring contaminant that commonly found in water supplies. Chronic exposure to arsenic has been associated with multisystem disease, including respiratory diseases such as viral infections. known regulate immune cell activity and shown alter NK frequency function. However, our knowledge on effects of response influenza remains limited. The following study aims identify the trioxide activation function against A virus...
ABSTRACT T cells are important for the control of acute myeloid leukemia (AML), a common and often deadly malignancy. We observed that some AML patient samples resistant to killing by human engineered cytotoxic CD4 + cells. Single-cell RNA-seq primary before after their interaction uncovered transcriptional programs correlate with sensitivity or resistance cell killing. Resistance-associated were enriched in patients poor survival, killing-resistant did not engage vitro . Killing-sensitive...
Abstract The nuclear factor erythroid 2-like 2 (Nrf2) transcription regulates a battery of detoxification and antioxidant genes following activation by cell stress. primary role Nrf2 in immune function was thought to occur as an indirect consequence oxidative We have previously demonstrated unknown immunomodulatory Nrf2, where the common food preservative, tBHQ, induced Nrf2-dependent skewing CD4+ T cells towards Th2 phenotype. Polarization resulted increased production cytokines DNA binding...
Influenza virus is estimated to cause millions of illnesses and thousands hospitalizations deaths yearly in the United States, making influenza a major public health concern. It well known that an early natural killer (NK) cell response against vital for effective viral clearance. Tert-butylhydroquinone (tBHQ) widely used food preservative with immunomodulatory activity. Our lab has shown tBHQ negatively impact NK activation, effector function, maturation ex vivo. However, little regarding...