A5046259949- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Neurological and metabolic disorders
- Dementia and Cognitive Impairment Research
- Infrared Thermography in Medicine
- Pharmacological Effects and Toxicity Studies
- Potassium and Related Disorders
- Clostridium difficile and Clostridium perfringens research
- Neonatal and fetal brain pathology
- Pain Management and Placebo Effect
- Lysosomal Storage Disorders Research
- Child and Animal Learning Development
- Genetic Neurodegenerative Diseases
- Amoebic Infections and Treatments
- Pain Mechanisms and Treatments
- Occupational Health and Performance
- Mercury impact and mitigation studies
- Restless Legs Syndrome Research
- Genetics and Neurodevelopmental Disorders
- Dialysis and Renal Disease Management
- Metabolism and Genetic Disorders
- Menopause: Health Impacts and Treatments
- Telomeres, Telomerase, and Senescence
- Neuroendocrine regulation and behavior
- Heavy Metal Exposure and Toxicity
Hospital de Clínicas de Porto Alegre
2017-2025
Universidade Federal do Rio Grande do Sul
2018-2025
Introduction The association between descending pain modulatory system (DPMS) dysfunction and fibromyalgia has been previously described, but more studies are required on its relationship with aberrant functional connectivity (FC) the motor prefrontal cortices. Objectives objective of this cross-sectional observational study was to compare intra- interhemispheric FC bilateral cortices in women fibromyalgia, comparing responders nonresponders conditioned modulation (CPM) test. Methods A...
Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a rare late complication of brain irradiation. Patients commonly present recurrent headaches, seizures, and paroxysmal focal neurological deficits including aphasia, negligence, or hemianopsia. We report 41-year-old male patient admitted to our emergency room with reduced level consciousness global aphasia. One month prior admission, he started frequent headache moderate intensity behavioral alterations, advancing...
Resting-state functional connectivity (rs-FC) may aid in understanding the link between pain-modulating brain regions and descending pain modulatory system (DPMS) fibromyalgia (FM). This study investigated whether differences rs-FC of primary somatosensory cortex responders non-responders to conditioned modulation test (CPM-test) are related pain, sleep quality, central sensitization, impact FM on quality life.This cross-sectional included 33 females with FM. was assessed by magnetic...
Fibromyalgia is a heterogenous primary pain syndrome whose severity has been associated with descending modulatory system (DPMS) function and functional connectivity (FC) between processing areas. The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism linked to vulnerability chronic pain. In this cross-sectional imaging genetics study, we investigated fibromyalgia, the relationship BDNF heterozygous genotypes (Val/Met), response pattern acute stimulus in motor...
Platyrrhini (New World monkeys, NWm) are a group of primates characterized by behavioral and reproductive traits that otherwise uncommon among primates, including social monogamy, direct paternal care, twin births. As consequence, the study Platyrrhine is an invaluable tool for discovery genetic repertoire underlying these taxon-specific traits. Recently, high conservation vasopressin (AVP) sequence, in contrast with variability oxytocin (OXT), has been described NWm. AVP OXT functions...
Abstract Background Dementia and cognitive impairment, primarily linked to aging, are increasingly recognized as multifactorial conditions. Emerging research has pointed early menopause another potential risk factor. However, its relationship with impairment needs further investigation, especially in low‐ middle‐income countries. Therefore, this study aims analyze the effect of on Brazilian population. Methods We analyzed data from Longitudinal Study Aging (ELSI‐Brazil), a nationally...
Abstract Background Cellular senescence (CS) is a hallmark of aging. Senescence‐associated secretory phenotype (SASP) index was recently developed based on the levels blood SASP‐related proteins. Although aging primary risk factor for Alzheimer's disease (AD), role CS in this neurodegenerative condition not well understood. Here, we investigated association SASP (SI) with classical markers AD. Methods We assessed 593 participants (60 cognitively unimpaired [CU], 412 mild cognitive impairment...
Abstract The impaired cortical function likely plays a critical role in chronic pain maintenance and fibromyalgia symptoms. Functional connectivity (FC), as assessed by functional near-infrared spectroscopy (fNIRS), is promising approach that evaluates activation through hemodynamic response estimation. This study compared the FC of bilateral motor prefrontal cortices between responders nonresponders to conditioned modulation test (CPM-test) induced hand immersion cold water (0–1°C). We...
Abstract Background Alzheimer’s disease (AD) represents a burdensome health condition worldwide and has highly clinical heterogeneity. In particular, the early‐onset presentations may be related to different risk factors underlying pathological mechanisms. We aimed compare frequency of modifiable factors/family history dementia in sample AD from tertiary memory outpatient clinic Southern Brazil. Method reviewed data patients clinically diagnosed with at Hospital de Clínicas Porto Alegre,...