Abstract A sensitive and highly selective stability-indicating gradient HPLC method was developed validated for simultaneous determination of clorsulon (CLO) ivermectin (IVM) in the presence their degradation products. The drugs were subjected to different stress conditions, including acid alkaline hydrolysis, oxidative, thermal, photolytic forced degradation. robustness proposed assessed using Plackett-Burman experimental design, factors affecting system performance defined, nonsignificant...

The use of electrochemical sensors offers a simple, affordable solution with great reliability. Magnesium is mineral that the body requires to function properly. It encourages preserving stable pulse, strong bones, and healthy blood pressure. Herein, novel ion-selective electrode using esomeprazole magnesium trihydrate as an ion-association complex was developed for magnesium(ii) ion determination in water, drug substances, pharmaceutical formulations. response optimized terms plasticizer...

Abstract Two rapid, precise, and sensitive stability-indicating high performance chromatographic methods for the measurement of Teriflunomide in its degradation products’ existence were developed. These RP-HPLC HPTLC using UV detector. HPLC separation was accomplished utilizing Thermo BDS hypercil C18 column (250 × 4.6 mm, 5 μm) acetonitrile: 0.03 M potassium dihydrogen phosphate: triethylamine (50:50:0.1%, by volume) as mobile phase at flow rate 1mL/min. The separated peaks detected 250.0...

Determination of terazosin hydrochloride dihydrate (TRZ) in drug substance and tablets was studied by potentiometeric fluorimetric techniques. method has focused on the fabrication two carbon paste ion selective electrodes for determination under investigation using potentiometric titration with phosphomolybdic acid (PMA), Phosphotungestic (PTA). The influence electrode composition, conditioning time pH test solution, performance were investigated. showed Nernstian response concentration...

Abstract Zinc oxide nanoparticles (ZnONPs) are used to modify carbon paste electrodes for a fast, stable, and sensitive electrochemical determination of difloxacin HCl in pharmaceutical formulation their photodegradation rate. The small particle size large surface area ZnONPs enhance the diffusion rates chosen target analyte many accessible binding sites, increasing range linear structure with low detection limit improving stability lifetime electrode. An initial optimization study included...

Triprolidine hydrochloride (TpCl) ion-selective carbon paste electrodes were constructed using Tp-TPB/Tp-CoN and Tp-TPB/Tp-PTA as ion-exchangers. The two revealed Nernstian responses with slopes of 58.4 58.1 mV decade−1 at 25 °C in the ranges 6 × 10−6–1 10−2 2 10−5–1 M for Tp-TPB/Tp-PTA, respectively. potentials these independent pH 2.5–7.0 4.5–7.0, detection limits 10−6 1 10−5 showed a very good selectivity TpCl respect to large number inorganic cations compounds. standard addition,...

The utility of carbon paste electrode for the determination flavoxate HCl modified with flavoxate-tetraphenylborate (FLX-TPB) and flavoxate-phosphotungestic acid (FLX-PTA) ion-pairs in batch mode is demonstrated. electrodes revealed a Nernstian response over wide concentration ranges 1.39×10 -5 -1x10 -2 mol L -1 and1×10 using FLX-TPB FLX-PTA, respectively. detection limits these sensors are , 1x10 -6 best performance was obtained composition 5% or flavoxate-phosphotungestate, 47.5% graphite...

Development in polymer chemistry empowers creative analytical solutions. Polymers have provided a multitude of separation modes solid-phase-extraction and chromatography, also they served as matrices for chemical sensors. The current study introduces polymeric cation-exchanger modifier solid-state Zn(II) sensor. Literature relates the deteriorated response limited performance potentiometric-sensors to leaching ion-exchanger and/or analyte out sensor matrix. polymer’s solubility, small...

Abstract Background: Few stability-indicating chromatographic methods were published for determination of daclatasvir. All used UV detection. Objective: This work aimed to develop rapid, specific, and novel using HPLC with fluorescence detection ultra performance liquid chromatography (UPLC) the daclatasvir in bulk powder its dosage form. Methods: The drug was subjected hydrolysis (acidic alkaline) as per International Conference on Harmonization (ICH) guidelines. fragmentation pattern...

Background: Oxyclozanide (OXY) is a veterinary medicine used for control of fascioliasis in farm animals. Literature review shows absence sufficient information regarding its stability. Such important as it affects many stages drug's life cycle, from pharmaceutical manufacturing to environmental fate understanding the degradation drug once placed environment. Objective: An HPLC method was developed address impact different stress conditions on OXY's Methods: stability investigated by...

Abstract Three smart carbon paste electrodes were fabricated to quantify the dorzolamide hydrochloride DRZ, including conventional I, modified embedding Silica II, and β-cyclodextrin III. This study is built on inserting of DRZ with phosphomolybdic acid create an electroactive moiety dorzolamide-phosphomolybdate ion exchanger using a solvent mediator dibutylphthalate. The three constructed displayed Nernstian responses linear concentration ranges lower detection limits. vital performance...

Two rapid, precise, and sensitive stability-indicating high performance chromatographic techniques for the measurement of Teriflunomide in its degradation products' existence were developed. These RP-HPLC HPTLC using UV detector. HPLC separation was accomplished utilizing Thermo BDS hypercilC18 (250 x 4.6mm, 5μm) acetonitrile: 0.03M potassium dihydrogen phosphate: triethylamine (50:50:0.1%, by volume) as mobile phase at flow rate 1mL/min. The separated peaks detected 250.0 nm. densitometric...

Abstract Three smart carbon paste electrodes were fabricated to quantify dorzolamide hydrochloride DRZ, including conventional I, modified embedding Silica II, and β-cyclodextrin III. This study is based on the insertion of DRZ with phosphomolybdic acid create an electroactive moiety dorzolamide-phosphomolybdate ion exchanger using a solvent mediator dibutyl phthalate. The three constructed displayed Nernstian responses linear concentration ranges lower detection limits. vital performance...