A5046904719- Developmental Biology and Gene Regulation
- Chronic Lymphocytic Leukemia Research
- Gut microbiota and health
- Hippo pathway signaling and YAP/TAZ
- Invertebrate Immune Response Mechanisms
- CAR-T cell therapy research
- PARP inhibition in cancer therapy
- Escherichia coli research studies
- Lymphoma Diagnosis and Treatment
- DNA Repair Mechanisms
- Immune Cell Function and Interaction
- Vibrio bacteria research studies
- Planarian Biology and Electrostimulation
- Synthesis and Biological Evaluation
- Synthesis and Reactivity of Heterocycles
- Tryptophan and brain disorders
- Bacterial Genetics and Biotechnology
- Synthesis and Characterization of Pyrroles
- Cytomegalovirus and herpesvirus research
- Marine Sponges and Natural Products
- Cellular Mechanics and Interactions
- Neurobiology and Insect Physiology Research
- Bacteriophages and microbial interactions
- Marine Invertebrate Physiology and Ecology
- Neuroinflammation and Neurodegeneration Mechanisms
Auburn University
2025
Aligarh Muslim University
2024
Dana-Farber Cancer Institute
2023-2024
Jawaharlal Nehru University
2023-2024
International Centre for Genetic Engineering and Biotechnology
2021
University of Illinois Urbana-Champaign
2015-2017
Indian Institute of Technology Kanpur
2009-2013
Regenerating tissue must initiate the signaling that drives regenerative growth, and sustain long enough for regeneration to complete. How these key signals are sustained is unclear. To gain a comprehensive view of changes in gene expression occur during regeneration, we performed whole-genome mRNAseq actively regenerating from damaged Drosophila wing imaginal discs. We used genetic tools ablate primordium induce carried out transcriptional profiling blastema by fluorescently labeling...
Abstract Osteosarcoma (OS) is a mesenchymal neoplasm. OS makes up approximately 3% of all malignancies in children. The mortality rate has not changed the last few decades; therefore, development advanced cancer therapies essential. We hypothesize that next-generation conditionally replicative oncolytic virus with an armed anti-PD1 HcAb will lyse cells and initiate immune response against tumor microenvironment.The purpose study to evaluate activity production/ secretion Hcab by Canine...
Only select cell types in an organ display neoplasia when targeted oncogenically. How developmental lineage hierarchies of these cells prefigure their neoplastic propensities is not yet well-understood. Here we show that Drosophila epithelial reverse commitments and switch to primitive states. In a context alleviated tissue surveillance, for example, loss Lethal giant larvae (Lgl) tumor suppressor the wing primordium induced its Homothorax (Hth)-expressing proximal domain. Transcriptional...
Although tissue regeneration has been studied in a variety of organisms, from Hydra to humans, many the genes that regulate ability each animal regenerate remain unknown. The larval imaginal discs genetically tractable model organism Drosophila melanogaster have complex patterning, well-characterized development and high regenerative capacity, are thus an excellent system for studying mechanisms regeneration. To identify important wound healing repair, we carried out genetic screen mutations...
P53 is a master transcriptional regulator and effector of the DNA damage response (DDR) that localizes to sites, in part, via an interaction with PARP1. However, mechanisms regulate p53 abundance activity at PARP1-decorated sites remain undefined. The PARP9 (BAL1) macrodomain-containing protein its partner DTX3L (BBAP) E3 ligase are rapidly recruited PARP1-PARylated sites. During initial DDR, we found colocalized p53, polyubiquitylated lysine-rich C-terminal domain, targeted for proteasomal...
Dissociation of imaginal disc cells has been carried out previously to enable flow cytometry and cell sorting analyze cycle progression, size, gene expression, other aspects tissues. However, the lengthy dissociation protocols employed may alter behavior overall viability. Here we describe a new rapid gentle method dissociating wing discs that significantly enhances viability reduces likelihood expression changes. Furthermore, this is scalable, enabling collection large amounts sample for...
Pyrazoline derivatives (
Abstract Background Enteropathogenic E. coli (EPEC) causes acute infantile diarrhea accounting for significant morbidity and mortality in developing countries. EPEC uses a type three secretion system to translocate more than twenty effectors into the host intestinal cells. At least four of these effectors, namely EspF, Map, EspG1/G2 NleA, are reported disrupt tight junction barrier. We have earlier that expression EspF Map MDCK cells depletion TJ membrane proteins compromises integrity In...
Background: Geraniol is a terpene alcohol occurring in the essential oils of several aromatic plants. It commercially used as fragrance compound cosmetics and products household. possesses number biological properties. Objective: To study effect geraniol on toxicity induced by paracetamol. Methods: In present study, at final concentration 0.0005, 0.0025, 0.0050 0.0075 M was mixed diet along with paracetamol third instar larvae transgenic Drosophila melanogaster (hsp70-lac Z)Bg9 were allowed...
Abstract Background Enteropathogenic E. coli (EPEC) causes acute infantile diarrhea accounting for significant morbidity and mortality in developing countries. EPEC uses a type three secretion system to translocate more than twenty effectors into the host intestinal cells. At least four of these effectors, namely EspF, Map, EspG1/G2 NleA, are reported disrupt tight junction barrier. We have earlier that expression EspF Map MDCK cells depletion TJ membrane proteins compromises integrity In...
Abstract Regenerating tissue must initiate the signaling that drives regenerative growth, and sustain long enough for regeneration to complete. How these key signals are sustained is unclear. To gain a comprehensive view of changes in gene expression occur during regeneration, we performed wholegenome mRNAseq actively regenerating from damaged Drosophila wing imaginal discs. We used genetic tools ablate primordium induce carried out transcriptional profiling blastema by fluorescent labeling...