A5013220855- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- 3D Printing in Biomedical Research
- Microbial Community Ecology and Physiology
- Legionella and Acanthamoeba research
- Biochemical and Structural Characterization
Yale University
2023-2025
Abstract Bacterial biofilms are formed on environmental surfaces and host tissues, facilitate colonization antibiotic resistance by human pathogens. Bacteria often express multiple adhesive proteins (adhesins), but it is unclear whether adhesins have specialized or redundant roles. Here, we show how the model biofilm-forming organism Vibrio cholerae uses two with overlapping distinct functions to achieve robust adhesion diverse surfaces. Both biofilm-specific Bap1 RbmC function as a...
ABSTRACT Biofilms are ubiquitous surface-associated bacterial communities embedded in an extracellular matrix. While it is commonly assumed that biofilm-dwelling cells glued together by the matrix, how cell-matrix interaction depends on specific biochemistry of matrix components and this varies during biofilm growth remains unclear. Here, we investigated interactions Vibrio cholerae ( Vc ), causative agent cholera. We combine genetics, microscopy, simulation, biochemical tools to show not...