A5016457785- Legionella and Acanthamoeba research
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- SARS-CoV-2 and COVID-19 Research
- Vibrio bacteria research studies
- Bacterial biofilms and quorum sensing
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Olfactory and Sensory Function Studies
- Computational Drug Discovery Methods
- Ocular Infections and Treatments
- Amoebic Infections and Treatments
- Pharmacological Receptor Mechanisms and Effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Chemical Reactions and Isotopes
- Cerebrospinal fluid and hydrocephalus
- Inflammasome and immune disorders
- Ion channel regulation and function
- Retinal and Optic Conditions
- Neurogenesis and neuroplasticity mechanisms
- Erythrocyte Function and Pathophysiology
- Parasitic Infections and Diagnostics
Schön Klinik Bad Aibling
2023-2025
Aga Khan University
2015-2024
Nankai University
2024
Mentor
2023
Pir Mehr Ali Shah Arid Agriculture University
2021
University of Lahore
2018
Aga Khan University Hospital
2016-2017
Sunway University
2016
East Surrey Hospital
2015
Aga Khan University
2014
The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and evoked a scare epic proportion regarding its potential to spread infect humans worldwide. As we are in midst an ongoing pandemic COVID-19, scientists struggling understand how it resembles differs from severe acute respiratory syndrome (SARS-CoV) at genomic transcriptomic level. In short time following outbreak, been shown that, similar SARS-CoV, COVID-19 virus exploits...
The recent outbreak of COVID-19 caused by SARS-CoV-2 coronavirus has turned the world into chaos with its ominously high rate transmissions. As infection become pandemic, scientific community is in a race against time to beat unraveling molecular targets and discover epitopes protein sequences for vaccines/antibodies synthesis. It been reported that addition conventional respiratory complains flu, patients are also exhibiting neurological signs symptoms. Recently, report patient loss...
With the ongoing pandemic of coronavirus diseases (COVID-19) caused by SARS-CoV-2, there has been a surge in research and publications related to its pathogenesis clinical presentation affected patients. Many aspects this novel virus have raised confusion including naming disease it causes, staging highlight few such occurrences. An emerging aspect COVID-19 is long-term effects, which absence any consensus termed as long-COVID long-haulers recent publications.1, 2 As zoonotic infection comes...
Abstract The bacteriophage behavior of SARS‐CoV‐2 during the acute and post‐COVID‐19 phases appears to be an important factor in development disease. early use antibiotics seems crucial inhibit disease progression—to prevent viral replication gut microbiome, control toxicological production from human microbiome. To study impact specific on recovery COVID‐19 long COVID (LC) taking into account: vaccination status, comorbidities, wave, time initiation antibiotic therapy concomitant...
With the ongoing pandemic of coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), our knowledge pathogenesis COVID-19 is still in its infancy. Almost every aspect pathogen remains largely unknown, ranging from mechanisms involved infection transmission, interplay with human immune system, and covert end-organ damage. has manifested itself worldwide a syndromic appearance that dominated respiratory dysregulations. While clinicians are focused...
The effects of clinically available drugs targeting muscarinic cholinergic, adrenergic, dopaminergic, and serotonergic receptors; intracellular calcium levels and/or the function calcium-dependent biochemical pathways; ion channels; cellular pumps were tested against a keratitis isolate Acanthamoeba castellanii belonging to T4 genotype. In vitro growth inhibition (amoebistatic) assays performed by incubating A. with various concentrations in medium for 48 h at 30°C. To determine amoebicidal...
Naegleria fowleri causes one of the most devastating necrotic meningoencephalitis in humans. The infection caused by this free-living amoeba is universally fatal within a week onset signs and symptoms disease called primary amoebic (PAM). In all affected patients, there always history entry water into nose. Even though diagnostic treatment protocols have been revised improved, obstinate nature can be gauged fact that mortality rate has persisted around ∼95% over past 60 years. Some...
Abstract Background Quelling microglial-induced excessive neuroinflammation is a potential treatment strategy across neurological disorders, including traumatic brain injury (TBI), and can be achieved by thalidomide-like drugs albeit this approved drug class compromised teratogenicity. Tetrafluorobornylphthalimide (TFBP) tetrafluoronorbornylphthalimide (TFNBP) were generated to retain the core phthalimide structure of thalidomide immunomodulatory imide (IMiD) class. However, classical...
Tire wear particles (TWPs), generated from tire abrasion, contribute significantly to environmental contamination. The toxicity of TWPs organisms has raised significant concerns, yet their effects on terrestrial plants remain unclear. Here, we investigated the long-term impact pristine and naturally aged water spinach (Ipomoea aquatica) its rhizospheric soil. results indicated that natural aging reduced TWPs, as evidenced by decreased levels polycyclic aromatic hydrocarbons (PAHs) in soil...
The bismuth tri-iodide ( B i I 3 ) is an inorganic compound. It the result of response and iodine, which has inspired enthusiasm for subjective investigation. topological indices are numerical invariants molecular graph that portray its topology normally invariants. In 1975, Randic presented, in a bond-added substance, index as descriptor portraying subatomic branching. this paper, we investigate precious stone structure chain sheet. Moreover, exact formulas degree-based added-substance...
Recent reports on acetylcholine muscarinic receptor subtype 3 (CHRM3) have shown its growth-promoting role in prostate cancer. Additional studies report the proliferative effect of cholinergic agonist carbachol cancer by agonistic action CHRM3. This study shows that type 1 (CHRM1) contributes toward proliferation and growth We used cytotoxic assays, microarray database CHRM downstream pathways' homology subtypes to uncover multiple signals leading Growth assays showed pilocarpine stimulates...
Acetylcholine (ACh) is the neurotransmitter of cholinergic signal transduction that affects target cells via muscarinic (mAChR) and nicotinic (nAChR) receptors embedded in cell membrane. Of bind to ACh, mAChRs execute several cognitive metabolic functions human central nervous system (CNS). Very little known about origins autocrine/paracrine roles ACh primitive life forms. With recent report evidence an binding mAChR1 like receptor Acanthamoeba spp., it was tempting investigate origin...
Graph theory has much great advances in the field of mathematical chemistry. Chemical graph become very popular among researchers because its wide applications The molecular topological descriptors are numerical invariants a and useful for predicting their bioactivity. A variety such indices studied used theoretical chemistry, pharmaceutical researchers, drugs different other fields. In this article, we study chemical an oxide network compute total eccentricity, average eccentricity based...
Amantadine has recently been shown to improve patients with COVID-19. In addition its known mechanism of actions, we performed docking prediction this drug on the receptor-binding domain severe acute respiratory syndrome coronavirus 2, SARS-CoV-2. We hypothesize that such interaction may possibly have contributed a role in clinical improvements reported.