A5102745033- Innovations in Medical Education
- Infection Control and Ventilation
- Silymarin and Mushroom Poisoning
- Economic Growth and Development
- COVID-19 and Mental Health
- Problem and Project Based Learning
- Infection Control in Healthcare
- Global Financial Crisis and Policies
- Monetary Policy and Economic Impact
- Biochemical effects in animals
- Tryptophan and brain disorders
- Olfactory and Sensory Function Studies
- Polyamine Metabolism and Applications
- Economic Growth and Productivity
- Market Dynamics and Volatility
- Family and Patient Care in Intensive Care Units
- Gout, Hyperuricemia, Uric Acid
- Global Educational Reforms and Inequalities
- Innovative Teaching Methods
- Health and Well-being Studies
- Evaluation of Teaching Practices
- Microplastics and Plastic Pollution
- Economic and Technological Innovation
- Advanced Chemical Sensor Technologies
- Synthesis and biological activity
Post Graduate Institute of Medical Education and Research
2018-2024
Rabindranath Tagore Medical College
2015-2024
Guru Nanak Dev University
2019-2024
Deen Dayal Upadhyaya Gorakhpur University
2023
Government Medical College, Amritsar
2022-2023
Punjab Agricultural University
2023
New York City Health and Hospitals Corporation
2023
Government of Himachal Pradesh
2023
Thapar Institute of Engineering & Technology
2022
Punjabi University
2017-2019
Abstract Recent studies have shown that silibinin induces p21/Cip1 and p27/Kip1 G1 arrest in different prostate cancer cells irrespective of p53 status; however, biological significance mechanism such induction not been studied. Here, using two cell lines DU145 22Rv1, representing androgen-independent androgen-dependent stages malignancy, first we investigated the importance p21 p27 silibinin-mediated arrest. Silencing individually by RNA interference showed marked reversal arrest; their...
Transcription factor signal transducer and activator of transcription (Stat)-3 is activated constitutively in prostate cancer (PCA) suggesting that its disruption could be an effective approach to control this malignancy. Here we assessed whether silibinin, a flavanone from Silybum marianum with proven anticancer efficacy various models, inhibits Stat3 activation DU145 cells, if it does, what the biological fate cells? At 50 muM or higher concentrations for 24 48 h, silibinin concentration...
Mutations in APC/β-catenin resulting an aberrant activation of Wnt/β-catenin pathway are common colorectal cancer (CRC), suggesting that targeting the β-catenin with chemopreventive/anticancer agents could be a potential translational approach to control CRC. Using human CRC cell lines harboring mutant (SW480) versus wildtype (HCT116) APC gene and alteration pathway, herein we performed both vitro vivo studies examine for first time whether silibinin targets its efficacy against Silibinin...
Introduction: Diabetes Mellitus (DM) is a metabolic disorder characterised by chronic hyperglycaemia, leading to systemic complications such as Diabetic Retinopathy (DR). The impact of DM on retinal thickness particular interest, it can serve an early indicator DR progression. Aim: To assess variations in among diabetic patients without involvement and also correlate with the duration diabetes Glycated haemoglobin (HbA1c) levels. Materials Methods: This cross-sectional study was conducted...
With the progression of Smart Cities and increasing demand for (IoT) Internet Things, accident management detection system has become common examined area. The density vehicles improved on paths produced an abundance difficulties in centers. lack transporting patients providing first aid medical service at appropriate time is major cause loss human lives. This paper investigates main possibilities arising from initiation innovative notion IoT VANET with introducing architecture. concept...
Management of high grade proximal tibia or tibial plateau fractures is often associated with complications. The use wire fixators for the definitive treatment such entails a minimally invasive technique insertion that gives good fracture reduction and stability combined minimal postoperative complications.To assess outcome by Joshi's external stabilization system (JESS), which based, circular fixator system.A prospective, uncontrolled study was done using JESS on 20 consecutive patients...
Background: Hypertension is one of the current emerging community health problems, which very common affecting in four individuals. Hyperuricemia predictive for development both hypertension and coronary artery disease. Since there are various etiological factors associated with so it difficult to predict most cause hypertension. Little or no information present population Rajasthan, on association between serum uric acid essential Hence this study carried out investigate existence an...
To determine if severity of osteoarthritis-related knee pain is associated with a willingness to undergo total replacement (TKR) and whether this association confounded or modified by components socioeconomic status health care coverage.Cross-sectional analysis was conducted among 3,530 Osteoarthritis Initiative study participants. Logistic regression models were used assess the effect (where 0 = none, 1-3 mild, 4-7 moderate, 8-10 severe) on TKR. Stratified analyses evaluate coverage modify...
Hypertension has turned out to be the major cause of morbidity among life style diseases. Studies in human and animal models have documented an independent association hyperuricaemia with early hypertension. Hyperuricaemia is a modifiable treatable risk factor, which might reduce incidence Essential (EHT).Hence, present study was designed find between EHT population Southern Rajasthan as there dearth literature on Indian scenario especially Rajasthan.A cross-sectional, case control carried...
Change has been the unwritten yet self-evident law of nature and society. However, in recent times pace, magnitude, complexities dimensions these changes got accelerated intensified. The can be discerned each sphere our lives including domain learning education sector. Scholars have identified four stages Education from 1.0 to 4.0. In phases, all characteristics change institutional arrangement, content organisation, orientation, technology, teaching-learning methods, role students teachers....
Tobacco consumption is a serious health hazard and most important avoidable cause of death worldwide. recognized as lethal toxin, ripping off 7-11 minutes human life with each cigarette through harmful compounds inducing free radical synthesis high rate lipid peroxidation. These radicals are scavenged by the endogenous antioxidants viz. S. Glutathione (S.GSH) α-Lipoic acid (S. α-LA), thus preventing endothelial damage.The present study was designed an aim to find out peroxidative stress...
During the post liberalisation period from 1991–92 to 2014–15 an increase in FDI inflows has been observed except for years 1998–99 1999–00, 2002–03 2003–04, 2009–10 2010–11 and 2012–13. The major chunk of is contributed by six countries viz., Mauritius, Singapore, UK, Japan, Netherlands US with highest proportion being service sector. In spite tremendous rise period, magnitude India very low comparison other emerging market economies due its weak infrastructure stringent laws. Empirical...