A5015418988- Phytochemical compounds biological activities
- Curcumin's Biomedical Applications
- Drug Transport and Resistance Mechanisms
- Synthesis of Organic Compounds
- Gold and Silver Nanoparticles Synthesis and Applications
- Carbon and Quantum Dots Applications
- Optical and Acousto-Optic Technologies
- Advanced Sensor and Energy Harvesting Materials
- Food composition and properties
- Polysaccharides Composition and Applications
- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Bioactive Compounds and Antitumor Agents
- Pharmaceutical Practices and Patient Outcomes
- Graphene and Nanomaterials Applications
- Biosensors and Analytical Detection
- Hepatitis C virus research
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Molecular Sensors and Ion Detection
- Nanoplatforms for cancer theranostics
- Genomics, phytochemicals, and oxidative stress
- Synthesis and Characterization of Pyrroles
- Nuclear Receptors and Signaling
- Synthesis of Indole Derivatives
Universiti Sains Malaysia
2015-2023
Hospital Universiti Sains Malaysia
2020
National University of Singapore
2008-2014
University of Southampton
2006
While the printed circuit board (PCB) has been widely considered as building block of integrated electronics, world is switching to pursue new ways merging electronic circuits with textiles create flexible and wearable devices. Herein, an alternative for PCB, we described a non-printed integrated-circuit textile (NIT) biomedical theranostic application via weaving method. All devices are built fibers or interlaced nodes woven into deformable circuit. Built on electrochemical gating...
We fabricated a novel nanowell enhanced Raman spectroscopy substrate that can capture and detect nanoplastics with the aid of coffee ring effect. Single polystyrene down to 200 nm be directly visualized.
Titanium dioxide nanoparticles (TiO2 NPs) have attracted tremendous interest owing to their unique physicochemical properties. However, the cytotoxic effect of TiO2 NPs remains an obstacle for wide-scale applications, particularly in drug delivery systems and cancer therapies. In this study, more biocompatible nitrogen-doped graphene quantum dots (N-GQDs) were successfully incorporated onto surface resulting a N-GQDs/TiO2 nanocomposites (NCs). The effects nanocomposite on viability breast...
Titanium dioxide nanoparticles (TiO
Abstract The ability of aurones to modulate the efflux activities ABCG2 and ABCB1 was investigated by quantifying their effects on accumulation pheophorbide A (PhA) in ABCG2‐overexpressing MDA‐MB‐231/R cells calcein AM ABCB1‐overexpressing MDCKII/MDR1 cells. Key structural features for interactions at both are a methoxylated ring A, an intact exocyclic double bond, location carbonyl bond C. Modifications rings B C were less critical served primarily moderate activity selectivity one or...
From a nutritional point of view, acylated starch appeared to be resistant (3,5).The nondigestible fraction was found able reduce postprandial blood glucose and insulin concentration (6), which helps
Triphenyltin chloride (TPhT) is an organotin compound that causes intensive toxicological risk to the environment and humans. A detection method with high sensitivity stability therefore desired better detect TPhT. In this study, a novel SERS substrate was prepared by sputtering ultra-thin Au layer on honeycomb-like silver nanoarray fabricated via nanosphere lithography method. The formed intermittent nanoparticles nanoarray, resulting in bimetallic coupling dramatically increased hotspots...
This study aims to investigate the blood-brain barrier (BBB) permeability of curcumin analogues with shortened linkers and their ability protect against amyloid-beta toxicity in a whole organism model.Four were synthesized. These evaluated for BBB parallel artificial membrane assay. The transgenic Caenorhabditis elegansGMC101 that expresses human Aβ1-42 was treated compounds evaluate delay Aβ-induced paralysis. Expression skn-1mRNA examined on nematodes selected efficacious compounds. In...
Whilst the potential of neural stem cell (NSC)-based treatment is recognized worldwide and seems to offer a promising therapeutic option for stroke treatments, there currently no full understanding regarding effects hypoxic baicalein-enriched fraction (BEF) preconditioning approaches on these cells stroke. The preconditioned NSC can be determined based expression several key neuroprotective genes using qRT-PCR technique. However, prior that, it imperative extremely important carefully select...
Previously, a series of aurones bearing amine and carbamate functionalities was synthesized evaluated for their cholinesterase inhibitory activity drug-like attributes. In the present study, these were multi-targeting properties in two Alzheimer's disease (AD)-related activities namely, monoamine oxidase (MAO) amyloid-beta (Aβ) inhibition. Evaluation MAO disclosed several potent selective inhibitors MAO-B, particularly those with 6-methoxyl group attached at ring A. Of different moieties as...
Glioblastoma multiforme (GBM) is the most malignant subtype of primary brain cancer. To date, standard clinical treatment for GBM limited in effectiveness and could impose additional side effects. Recently, numerous bioactive compounds isolated from natural plants appear to have beneficial anti-cancer properties. Here, inhibitory effect baicalein, a flavonoid extracted Oroxylum indicum (L.) Benth. ex Kurz, was evaluated. Firstly, three solvents were used extract baicalein. We found that...
The performance of small wearable or robotic devices is limited by the energy and power density batteries. We present a rechargeable aqueous gel-type AgO-Zn battery, with 17.9 W/cm3 an 624 mWh/cm3 at 0.2C 358 50C. designed multilayered fractal ion-channel structure for long, fibrous AgO electrode using twisting method. A prototype headband 2 cm × 25 woven batteries was tested. With output >4 W, battery can extend operation time commercial augmented reality glasses from h to over 12 h....