A5017556766- Multiple Sclerosis Research Studies
- Systemic Sclerosis and Related Diseases
- Ultrasound and Hyperthermia Applications
- Parasitic infections in humans and animals
- Parasites and Host Interactions
- Rheumatoid Arthritis Research and Therapies
- Peripheral Neuropathies and Disorders
- Advanced MRI Techniques and Applications
- Parasite Biology and Host Interactions
- Electron Spin Resonance Studies
- Cytokine Signaling Pathways and Interactions
- Full-Duplex Wireless Communications
- Polyomavirus and related diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Lupus Erythematosus Research
Departament de Salut
2023-2025
Universitat de Barcelona
2023-2025
Institut d'Investigació Biomédica de Bellvitge
2022-2024
Bellvitge University Hospital
2022-2024
MRI is essential for monitoring multiple sclerosis (MS). Contrast-enhanced T1-weighted imaging (T1WI+C) detects active inflammatory lesions indicating blood-brain barrier breakdown and relevant disease treatment optimization. Susceptibility-weighted (SWI) may be included in the protocol detecting MS-specific features, such as presence of central veins or paramagnetic rim lesions. However, post-contrast SWI (SWI+C) has an inherent "T1 shine-through effect" that enables visualization...
Objectives: To compare the performance of 3D T1 turbo spin echo (3DT1TSE) and field (3DT1TFE) MRI in detecting gadolinium-enhancing lesions multiple sclerosis (MS). Methods: We retrospectively analyzed 255 3T MRIs from MS patients, each including post-contrast 3DT1TSE 3DT1TFE sequences. Two blinded readers independently assessed enhancing per sequence. A consensus review, incorporating longitudinal imaging additional sequences, served as reference standard. Results: The identified 70 31...
Paramagnetic rim lesions (PRLs), usually identified in susceptibility-weighted imaging (SWI), are a promising prognostic biomarker of disability progression multiple sclerosis (MS). However, SWI is not routinely performed clinical practice. The objective this study to define novel sign, the T1-dark rim, identifiable standard 3DT1 gradient-echo inversion-recovery sequence, such as 3D T1 turbo field echo (3DT1FE) and explore its performance surrogate PRLs.
Introduction The role of the kappa-free light chain (kFLC) in diagnosis multiple sclerosis (MS) and, to a lesser extent, its as medium-term prognostic marker have been extensively studied. This study aimed explore potential long-term for MS. Methods We performed an exploratory retrospective observational by selecting patients systemically followed up our MS unit with available cerebrospinal fluid and serum samples at time initial evaluation. Two groups were defined: benign (bMS), defined...
<title>Abstract</title> Neurocysticercosis is particularly severe when affecting the subarachnoid space (SUBNCC). While antiparasitic therapy effectively controls infection, it can lead to significant complications. This study aims characterize a cohort of patients with SUBNCC, focus on their clinical course depending therapeutic interventions. We conducted an observational, retrospective involving diagnosed SUBNCC at tertiary hospital between 1985 and 2022. The primary endpoint was...
People with multiple sclerosis (MS) present varying degrees of disability throughout their disease course. The Multiple Sclerosis Severity Score (MSSS) and the Age-Related (ARMSSS) adjust Expanded Disability Status Scale (EDSS) according to duration age, respectively. These measures could be useful for quantifying MS severity as health outcome indicators benchmarking in population-based settings. aim this study was describe our district using MSSS ARMSSS assess consistency over time.
Prior studies have suggested that cardiovascular risk factors (CVRFs) can affect the prognosis of multiple sclerosis (MS). The aim this study was to assess if CVRFs early course MS.A retrospective observational performed, including patients diagnosed with relapsing-remitting MS (RRMS) from 2010 2020, at least 2 years disease and 6 months follow-up. Age onset, duration, number relapses, time confirmed Expanded Disability Status Scale (EDSS) 3.0 6.0, secondary progressive (SPMS) were...
Abstract Background Natalizumab (NTZ) and ocrelizumab (OCR) can be used for the treatment of relapsing–remitting multiple sclerosis (RRMS). In patients treated with NTZ, screening JC virus (JCV) is mandatory, a positive serology usually requires change in after 2 years. this study, JCV was as natural experiment to pseudo-randomize into NTZ continuation or OCR. Methods An observational analysis who had received at least years were either changed OCR maintained on depending status, performed....
Abstract Objectives: Paramagnetic rim lesions (PRLs), usually identified in susceptibility-weighted imaging (SWI), are a promising prognostic biomarker of disability progression multiple sclerosis (MS). However, SWI is not always available clinical practice. The objective this study to define novel sign, the T1-dark rim, identifiable standard 3DT1 gradient-echo sequence, such as 3D T1 turbo field echo (3DT1FE) and explore its performance surrogate PRLs. Materials & Methods: This...