A5051980297- Poisoning and overdose treatments
- Pharmacology and Obesity Treatment
- Drug-Induced Hepatotoxicity and Protection
- Veterinary Pharmacology and Anesthesia
- Diabetes Management and Research
- Diabetes Treatment and Management
- Vascular Malformations and Hemangiomas
- Diabetic Foot Ulcer Assessment and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Central Venous Catheters and Hemodialysis
- Cassava research and cyanide
- Cardiac Arrest and Resuscitation
- Analytical Methods in Pharmaceuticals
- Liver Disease and Transplantation
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacogenetics and Drug Metabolism
- Asthma and respiratory diseases
- Cardiac electrophysiology and arrhythmias
- Heme Oxygenase-1 and Carbon Monoxide
- Respiratory and Cough-Related Research
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Neurological and metabolic disorders
Washington Poison Center
2018-2025
Regions Hospital
2013-2025
HealthPartners
2016
Sotalol is a beta-adrenoceptor blocking drug with unique physical and pharmacologic properties. Unlike most drugs, sotalol amenable to extracorporeal removal causes QT interval prolongation ventricular dysrhythmias. These properties have implications for treating poisoning. Patient 1: A man in his seventh decade of life overdosed on 9 g presented bradycardia, hypotension, >600 ms transient tachycardia. Dopamine, isoprenaline (isoproterenol), transvenous pacemaker were used instead high-dose...
Nadolol is a β-adrenergic antagonist that has been shown to be efficacious in the treatment of infantile hemangioma. It suggested this drug may have fewer side effects compared with gold standard therapy, propranolol, because it does not exhibit membrane-stabilizing and little ability cross blood-brain barrier. However, pharmacokinetics safety nadolol infants are well understood, potentially making therapy dangerous. toxicity causes bradycardia, hypotension, hypoglycemia, even death. We...
Context: Although cerebral perfusion (CP) is preserved across a wide range of mean arterial pressures (MAP) through cerebral-vascular autoregulation, the relationship between MAP and CP in refractory poison-induced cardiogenic shock (PICS) has never been studied. We compared effects therapies used PICS: high-dose insulin (HDI), HDI plus norepinephrine (NE), vasopressors alone (NE epinephrine (Epi)) on tissue oxygenation (PtO2).Methods: Fifteen swine were randomized to either HDI, + NE, or NE...
We present a patient who presented 37 times after large acute acetaminophen ingestions without residual signs of liver dysfunction. The presentations were all very similar: witnessed 25 g presenting within 1 h. Due to potentially toxic serum concentration, she received N-acetylcysteine 16 12-month period and 21 overall. This case is an extreme real-life example regarding the absence subsequent hepatic injury with repeated requiring treatments despite theoretical vulnerable time immediately overdose.