A5007255214- Retinal Development and Disorders
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Influenza Virus Research Studies
- Cellular transport and secretion
- Viral Infections and Immunology Research
Vrije Universiteit Amsterdam
2018
Radboud University Nijmegen
2016
Radboud University Medical Center
2016
Abstract Recent advances in live Ca 2+ imaging with increasing spatial and temporal resolution offer unprecedented opportunities, but also generate an unmet need for data processing. Here we developed SICT, a MATLAB program that automatically identifies rapid rises time-lapse movies low signal-to-noise ratios, using fluorescent indicators. A graphical user interface allows visual inspection of detected events, reducing manual labour to less than 10% while maintaining quality control. The...
The molecular mechanisms that promote excitatory synapse development have been extensively studied. However, the events preventing precocious so synapses form at correct time and place are less well understood. Here, we report functional characterization of ARHGAP12, a previously uncharacterized Rho GTPase-activating protein (RhoGAP) in brain. ARHGAP12 is specifically expressed CA1 region hippocampus, where it localizes to postsynaptic compartment synapses. negatively controls spine size via...