A5037455102- Rheumatoid Arthritis Research and Therapies
- Erythrocyte Function and Pathophysiology
- Monoclonal and Polyclonal Antibodies Research
- Adrenal Hormones and Disorders
- Fibroblast Growth Factor Research
- Medical and Biological Ozone Research
- Bone and Joint Diseases
- Systemic Sclerosis and Related Diseases
- Cellular Mechanics and Interactions
- Spondyloarthritis Studies and Treatments
- Ion channel regulation and function
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Hippo pathway signaling and YAP/TAZ
- Blood properties and coagulation
- Systemic Lupus Erythematosus Research
University of Leeds
2019-2023
University of Birmingham
2005
Immune Regulation (United Kingdom)
2005
Chaperonins have classically been thought of as intracellular molecules involved in the correct folding proteins.Their expression is upregulated during times stress such heat (hence their common nomenclature shock proteins [HSP]), anoxia, hypoglycaemia and reactive oxygen species [1].These are conditions found infected tissues or with chronic inflammation rheumatoid synovium.In location they protect cell from apoptotic death due to stress.Increasingly chaperonins recognised subserve...
Abstract Mechanical force has emerged as a determinant of Notch signalling but the mechanisms sensing and coupling to are unclear. Here we propose role for Piezo1 channels, recently identified mechanosensors mammalian systems. channel opening in response shear stress or chemical agonist led activation disintegrin metalloproteinase domain-containing protein 10 (ADAM10), Ca 2+ -regulated transmembrane sheddase that mediates S2 Notch1 cleavage. Consistent with this observation there was...
ABSTRACT Generalised Lymphatic Dysplasia (GLD) is characterised by widespread lymphoedema, with at least one of the following: fetal hydrops, intestinal or pulmonary lymphangiectasia, pleural effusions, pericardial effusions and ascites. Satisfactory medical therapies are lacking. A genetic association has been identified that prevents expression surface trafficking PIEZO1, a subunit mechanically activated calcium-permeable channels. However, PIEZO1 large highly polymorphic gene...
New dimensions in our understanding of immune cell trafficking have been opened by the discovery chemokines and their receptors. This family chemo-attractant cytokines shares a high degree structural homology, performing essential roles recruitment subsequent positioning leucocyte subsets within tissue microenvironments. Diverse demonstrated inflammation, tumorigenesis haematopoiesis, addition to crucial lymphoid development. Investigation chemokine networks offers novel approach many poorly...
Chaperonins have classically been thought of as intracellular molecules involved in the correct folding proteins.Their expression is upregulated during times stress such heat (hence their common nomenclature shock proteins [HSP]), anoxia, hypoglycaemia and reactive oxygen species [1].These are conditions found infected tissues or with chronic inflammation rheumatoid synovium.In location they protect cell from apoptotic death due to stress.Increasingly chaperonins recognised subserve...