A5101803012- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Biochemical effects in animals
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Pregnancy and preeclampsia studies
- Neuroendocrine regulation and behavior
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Sleep and Wakefulness Research
- Autophagy in Disease and Therapy
- Adenosine and Purinergic Signaling
- Agricultural Practices and Plant Genetics
- Banana Cultivation and Research
- Metabolomics and Mass Spectrometry Studies
- Cellular transport and secretion
- Legume Nitrogen Fixing Symbiosis
- Mitochondrial Function and Pathology
- Blood Coagulation and Thrombosis Mechanisms
- Neurological Disease Mechanisms and Treatments
- Food Science and Nutritional Studies
- Complement system in diseases
- Erythrocyte Function and Pathophysiology
- Advanced Proteomics Techniques and Applications
University of Copenhagen
2022-2024
Eötvös Loránd University
2016-2022
Hungarian Academy of Sciences
1961
Institute of Genetics
1961
Preeclampsia is a disease of the mother, fetus and placenta, gaps in our understanding complex interactions among their pathways withheld successful treatment prevention. The placenta has key role pathogenesis terminal pathway characterized by exaggerated maternal systemic inflammation, generalized endothelial damage, hypertension proteinuria. This sine qua non preeclampsia may be triggered distinct underlying mechanisms that occur at early stages pregnancy induce different phenotypes. To...
Significance Synaptic pruning is dominant in early ontogenesis when a large number of unnecessary synapses are eliminated, and it maintains synaptic plasticity the mature healthy brain, e.g., memory processes. Its malfunction involved degenerative diseases such as Alzheimer’s disease. C1q, member immune complement system, plays central role selective by microglial phagocytosis. Understanding molecular aspects complement-mediated synapse elimination high importance for developing effective...
Abstract Synaptic functional disturbances with concomitant synapse loss represent central pathological hallmarks of Alzheimer’s disease. Excessive accumulation cytotoxic amyloid oligomers is widely recognized as a key event that underlies neurodegeneration. Certain complement components are crucial instruments widespread because they can tag synapses impairments leading to their engulfment by microglia. However, an exact understanding the affected synaptic functions predispose...
Abstract Synaptosomes are frequently used research objects in neurobiology studies focusing on synaptic transmission as they mimic several aspects of the physiological functions. They contain whole apparatus for neurotransmission, presynaptic nerve ending with vesicles, mitochondria and often a segment postsynaptic membrane along density is attached to its outer surface. As being artificial functional organelles, synaptosomes viable hours, retain their activity, potential, capable store,...
The human placenta maintains pregnancy and supports the developing fetus by providing nutrition, gas-waste exchange, hormonal regulation, an immunological barrier from maternal immune system. villous syncytiotrophoblast carries most of these functions provides interface between fetal circulatory systems. is generated biochemical morphological differentiation underlying cytotrophoblast progenitor cells. dysfunction trophoblast development implicated in placenta-mediated complications. Herein,...
Elements of the immune system particularly that innate immunity, play important roles beyond their traditional tasks in host defense, including manifold nervous system. Complement-mediated synaptic pruning is essential developing and healthy functioning brain becomes aberrant neurodegenerative disorders. C1q, component classical complement pathway, plays a central role tagging synapses for elimination; however, underlying molecular mechanisms interaction partners are mostly unknown. Neuronal...
Sleep deprivation (SD) is commonplace in the modern way of life and has a substantial social, medical, human cost. induces cognitive impairment such as loss executive attention, working memory decline, poor emotion regulation, increased reaction times, higher functions are particularly vulnerable to sleep loss. Furthermore, SD associated with obesity, diabetes, cardiovascular diseases, cancer, vast majority psychiatric neurodegenerative disorders accompanied by disturbances. Despite...
In synapses that show signs of local apoptosis and mitochondrial stress undergo neuro-immunological synapse pruning, an increase in the levels presynaptic protein, neuronal-specific septin-3 can be observed. Septin-3 is a member septin GTPase family with ability to form multimers contribute cytoskeleton. However, function remains elusive. Here, we provide evidence capable binding most-studied autophagy protein Atg8 homolog microtubule-associated 1 light chain 3B (LC3B), besides another...
During chronic cerebral hypoperfusion (CCH), the blood flow gradually decreases, leading to cognitive impairments and neurodegenerative disorders, such as vascular dementia. The reduced oxygenation, energy supply induced metabolic changes, insufficient neuroplasticity could be reflected in synaptic proteome. We performed stepwise bilateral common carotid occlusions on rats studied proteome changes of hippocampus, occipital frontal cortices. Samples were prepared separated by 2-D DIGE...
Complement component C1q is a protein complex of the innate immune system with well-characterized binding partners that constitutes part classical complement pathway. In addition, was recently described in central nervous as having role synapse elimination both healthy brain and neurodegenerative diseases. However, molecular mechanism C1q-associated phagocytosis still unclear. Here, we designed monomer multimer constructs, which comprised globular interaction recognition parts mouse...