A5003391706- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- RNA Research and Splicing
- Sperm and Testicular Function
- Chromosomal and Genetic Variations
Ohana Biosciences (United States)
2019-2021
Sperm-specific natural selection Sperm cells are genetically haploid, but because of the cytoplasmic bridges that link cells, they can be transcriptionally diploid. However, some gene transcripts not shared. Bhutani et al. sequenced single sperm from mice, cattle, and macaques to determine extent distortion in expression these putatively selfish transcripts, which authors call genoinformative markers (GIMs). Investigating evolutionary pressures on GIMs, found exhibited signatures positive...
1 Abstract Mendel’s first law dictates that alleles segregate randomly during meiosis and are distributed to offspring with equal frequency, requiring sperm be functionally independent of their genetic payload. Developing mammalian spermatids have been thought accomplish this by freely sharing RNA from virtually all genes through cytoplasmic bridges, equalizing allelic gene expression across different genotypes. Applying single cell sequencing developing spermatids, we identify a large class...