A5022046280- Antimicrobial Resistance in Staphylococcus
- Bacillus and Francisella bacterial research
- Antifungal resistance and susceptibility
- Streptococcal Infections and Treatments
- Bacterial biofilms and quorum sensing
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune cells in cancer
- Bacterial Genetics and Biotechnology
- Blood disorders and treatments
- Advances in Cucurbitaceae Research
- Histone Deacetylase Inhibitors Research
- Infective Endocarditis Diagnosis and Management
- Orthopedic Infections and Treatments
- Peptidase Inhibition and Analysis
Fujian Medical University
2022-2024
Shanghai Children's Medical Center
2020
Shanghai Jiao Tong University
2020
University of Science and Technology of China
2014
Point mutations with unclear molecular mechanisms are often associated vancomycin resistance in Staphylococcus aureus. Here, we observed that the walK (G223D) mutation caused decreased expression of genes cell wall metabolism, autolytic activity, thickened walls, and reduced susceptibility. A phosphorylation assay showed WalK exhibited autophosphorylation, which led to WalR. An electrophoretic mobility shift indicated (G223D)-phosphorylated WalR had a capacity bind atlA promoter.
Abstract Staphylococcal aureus ( S. ) infection can lead to a wide range of diseases such as sepsis and pneumonia. superantigen-like (SSL) proteins, expressed by all known strains, are shown be involved in immune evasion during infection. Here, we show that SSL10, an SSL family protein, exhibits potent cytotoxicity against human cells (HEK293T HUVEC) inducing necroptosis upon binding its receptor TNFR1 on the cell membrane. After binding, two distinct signaling pathways activated downstream...
Delays in the diagnosis of pediatric osteoarticular infections (OAIs) can cause associated acute complications or long-term morbidity. This study attempts to develop a multiplex PCR-based assay that rapidly and accurately detect main pathogens involved OAIs, namely, methicillin-sensitive methicillin-resistant Staphylococcus aureus, Streptococcus pyogenes Pseudomonas aeruginosa.A set four gene-specific primers suitable for use one-tube PCR was designed common nuc mecA spyM orpI aeruginosa....
High-fat diet (HFD) induces low-grade chronic inflammation, contributing to obesity and insulin resistance. However, the precise mechanisms triggering obesity-associated metabolic inflammation remain elusive. In this study, we identified epigenetic factor Brd4 as a key player in process by regulating expression of Ccr2/Ccr5 colonic macrophage. Upon 4-week HFD, myeloid-lineage-specific deletion (Brd4-CKO) mice showed reduced macrophage infiltration with decreased Ccr2 Ccr5. Mechanistically,...