A5053458160- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Pancreatic function and diabetes
- Cardiovascular and exercise physiology
- Diet and metabolism studies
- Pickering emulsions and particle stabilization
- Biochemical effects in animals
- Cardiac Ischemia and Reperfusion
- Heart Rate Variability and Autonomic Control
- Genetic Neurodegenerative Diseases
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Surfactants and Colloidal Systems
- Enhanced Oil Recovery Techniques
- Genetic factors in colorectal cancer
- Mitochondrial Function and Pathology
- Muscle activation and electromyography studies
- Glycogen Storage Diseases and Myoclonus
- Advanced Proteomics Techniques and Applications
- ATP Synthase and ATPases Research
- Amyotrophic Lateral Sclerosis Research
Fukuoka University
2020-2025
National Institute of Advanced Industrial Science and Technology
2023-2025
University of Copenhagen
2019-2024
Ritsumeikan University
2015-2023
Kyoto University
2019-2022
Osaka Institute of Technology
2017-2019
National Defense Academy of Japan
2016
Hahnemann University Hospital
2000
Animal models of colitis, which develop dysplasia and cancer similar to human ulcerative colitis are needed further investigate the sequence. This study describes expression B-catenin p53 along with histopathology inflammation scores as they relate in dextran sulfate sodium (DSS) model. Swiss Webster mice were fed 5% DSS follows: group A, four cycles DSS, 84 days total (1 cycle = 7 + 14 H(2)O); B, followed by 120 H(2)O, 204 total; C, 180 187 D, 90 97 total. The incidences and/or 15.8, 37.5,...
Ischemic preconditioning (IPC) improves maximal exercise performance. However, the potential mechanism(s) underlying beneficial effects of IPC remain unknown. The dynamics pulmonary oxygen uptake (VO2) and muscle deoxygenation during is frequently used for assessing O2 supply extraction. Thus, this study examined on systemic local incremental step transitions from low- to moderate- severe-intensity exercise. Fifteen healthy, male subjects were instructed perform work-to-work cycling test,...
Ischemic preconditioning (IPC) enhances whole-body exercise endurance. However, it is poorly understood whether the beneficial effects originate from systemic (e. g., cardiovascular system) or peripheral skeletal muscle) adaptations. The present study examined of IPC on local muscle endurance during fatiguing isometric exercise. 12 male subjects performed sustained unilateral knee-extension at 20% maximal voluntary contraction until failure. Prior to exercise, completed control (CON)...
New Findings What is the central question of this study? Does an acute bout exercise alter vitamin D receptor expression in rat skeletal muscle? main finding and its importance? Resistance but not endurance increased intramuscular expression. Thus, resistance may be effective way to increase muscle Vitamin (VDR) are involved maintenance mass function. Although well known enhance growth improve function, effect on VDR has been unclear. We investigated response or exercise. Male adult...
Acute aerobic exercise (AE) is a major physiological stimulus for skeletal muscle glucose uptake through activation of 5′ AMP-activated protein kinase (AMPK). However, the regulation by acute resistance (RE) remains unclear. To investigate intracellular after RE versus AE, male Sprague–Dawley rats were divided into three groups: RE, or nonexercise control. After fasting 12 h overnight, right gastrocnemius in group was exercised at maximum isometric contraction via percutaneous electrical...
Muscle insulin sensitivity for stimulating glucose uptake is enhanced in the period after a single bout of exercise. We recently demonstrated that AMPK necessary AICAR, contraction, and exercise to enhance muscle whole-body mice. Correlative observations from both human rodent skeletal suggest regulation phosphorylation status TBC1D4 may relay this sensitization. However, necessity phenomenon has not been proven. Thus, purpose study was determine whether enhancing response AICAR contraction....
Evidence for AMP-activated protein kinase (AMPK)-mediated regulation of skeletal muscle metabolism during exercise is mainly based on transgenic mouse models with chronic (lifelong) disruption AMPK function. Findings such are potentially biased by secondary effects related to a lack To study the direct effect(s) exercise, we generated new model inducible muscle-specific deletion AMPKα catalytic subunits in adult mice.Tamoxifen-inducible and AMPKα1/α2 double KO mice (AMPKα imdKO) were using...
Glycative stress, characterized by the formation and accumulation of advanced glycation end products (AGEs) associated with protein reactions, has been implicated in inducing a decline muscle function. Although inverse correlation between glycative stress mass strength demonstrated, underlying molecular mechanisms are not fully understood. This study aimed to elucidate how affects skeletal muscle, particularly adaptive response hypertrophic stimuli its mechanism.
Resistance training with eccentric contraction has been shown to augment muscle hypertrophy more than other modes do (i.e., concentric and isometric contraction). However, the molecular mechanisms involved remain unclear. The purpose of this study was investigate effect mode on mammalian target rapamycin complex 1 (mTORC1) signaling using a standardized force-time integral (load (weight) × time). Male Sprague–Dawley rats were randomly assigned three groups: contraction, contraction. right...
Abstract Acute aerobic exercise (AE) increases skeletal muscle insulin sensitivity for several hours, caused by acute activation of AMP-activated protein kinase (AMPK). resistance (RE) also activates AMPK, possibly improving insulin-stimulated glucose uptake. However, RE-induced rapamycin-sensitive mechanistic target rapamycin complex 1 (mTORC1) is higher and has a longer duration than after AE. In molecular studies, mTORC1 was shown to be upstream receptor substrate (IRS-1) Ser...
The ability of insulin to stimulate glucose uptake in skeletal muscle is important for whole-body glycemic control. Insulin-stimulated improved the period after a single bout exercise, and accumulating evidence suggests that phosphorylation TBC1D4 by protein kinase AMPK primary mechanism responsible this phenomenon. To investigate this, we generated knock-in mouse model with serine-to-alanine point mutation at residue 711 phosphorylated response both activation. Female TBC1D4-S711A mice...
Exercise increases muscle glucose uptake independently of insulin signaling and represents a cornerstone for the prevention metabolic disorders. Pharmacological activation exercise-responsive AMPK in skeletal has been proven successful as therapeutic approach to treat disorders by improving homeostasis through regulation uptake. However, conflicting observations cloud proposed role necessary regulator during exercise. We show that human absence exercise exercise-stimulated AMPKγ3 activity...
ABSTRACT Background While decreased protein intake is associated with muscle mass loss, it unclear whether a decrease in carbohydrate adversely affects atrophy independently of intake. Herein, we examined low‐carbohydrate (low‐CHO) diet exacerbates denervation‐induced under conditions identical Methods On day one the experiment, male Wistar rats underwent unilateral denervation. The contralateral leg was used as control. After denervation, were divided into two dietary groups:...
<title>Abstract</title> <bold>Aims </bold>To investigate the differences in gait characteristics between older patients with type 2 diabetes and without sarcopenia, using a three-dimensional motion analysis system. Methods: This cross-sectional study included 38 aged ≥ 65 years capable of independently performing activities daily living. Participants’ demographic data, spatiotemporal parameters, ranges pelvis, hip, knee, ankle joints during cycle were collected. Results: The participants...
The process of mitochondrial translation, in which (mt)DNA-encoded genes are translated into proteins, is crucial for function and biogenesis. In each phase, a series translation factors required the synthesis mtDNA-encoded proteins. Two initiation (mtIF2 mtIF3), three elongation (mtEFTu, mtEFTs, mtEFG1), one release factor (mtRF1L), two recycling (mtRRF1 mtRRF2) that coordinate translational phase. Exercise increases both nuclear DNA- resulting biogenesis skeletal muscles. Therefore, likely...
Resistance training (RT) has been known to be effective in maintaining and improving bone strength, which is based on mineral density (BMD) quality. However, it not clear whether RT strength patients with type-2 diabetes mellitus (T2DM), who have a high risk of fracture. Therefore, we tested the effects 6-week regimen using percutaneous electrical stimulation T2DM model rats, male Otsuka Long-Evans Tokushima Fatty (OLETF), its control, (LETO). After 6 weeks RT, tibial BMD legs was...
What is the central question of this study? Type 2 diabetes mellitus (T2DM) causes skeletal muscle atrophy; does it affect resistance training (RT)-mediated molecular adaptations and subsequent hypertrophy? main finding its importance? Although mass regulation were not preserved under conditions T2DM, response RT-induced hypertrophy was impaired in T2DM rat muscle. These findings suggest that capacity RT-mediated gain diminished condition.Type known to cause atrophy. However, whether affects...
Adapter protein containing Pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) and leucine zipper motif 1 (APPL1) has been reported as a positive regulator of insulin-stimulated Akt activation. The expression APPL1 is reduced in skeletal muscles type 2 diabetic (T2D) animals, implying that may be an important factor affecting insulin sensitivity. However, the regulation physiological interventions modulating these effects are unclear. Accordingly, we first confirmed...
Mitochondrial function in skeletal muscle and white adipose tissue (WAT) declines with aging the progression of type 2 diabetes insulin resistance. Although exercise increases mitochondrial biogenesis both tissues, molecular mechanisms are not fully understood. CDGSH iron sulfur domain-containing proteins (CISDs) a novel family that regulate activity biogenesis. However, relationship between CISD expression is unclear. We addressed this present study by examining changes CISDs WAT mice...
Insulin stimulates skeletal muscle glucose uptake via activation of the protein kinase B/Akt (Akt) pathway. Recent studies suggest that insulin downregulates AMP-activated (AMPK) activity Ser485/491 phosphorylation AMPK α-subunit. Thus lower blood concentrations may induce signal activation. Acute exercise is one method to stimulate activation; however, no study has examined relationship between levels and acute resistance exercise-induced pathway Based on previous findings, we hypothesized...
Previous studies have reported that different modes of muscle contraction (i.e., eccentric or concentric contraction) with similar times can affect proteolytic responses. However, the effect on response under same force−time integral (FTI: force × time) has not been investigated. The purpose this study was to investigate modes, FTI, acute signaling Eleven-week-old male Sprague–Dawley rats were randomly assigned (EC), (CC), isometric (IC) groups. Different performed right gastrocnemius using...