A5089887179- Hedgehog Signaling Pathway Studies
- Toxic Organic Pollutants Impact
- Tumors and Oncological Cases
- Developmental Biology and Gene Regulation
- Effects and risks of endocrine disrupting chemicals
- Pancreatic and Hepatic Oncology Research
- Congenital limb and hand anomalies
University of Michigan
2022
Michigan United
2022
North Carolina State University
2019
Proper Hedgehog (HH) signaling is essential for embryonic development, while aberrant HH drives pediatric and adult cancers. frequently dysregulated in pancreatic cancer, yet its role remains controversial, with both tumor-promoting tumor-restraining functions reported. Notably, the GLI family of transcription factors (GLI1, GLI2, GLI3), remain largely unexplored cancer. We therefore investigated individual combined contributions GLI1-3 to cancer progression. At pre-cancerous stages,...