A5007161363- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Chemical Synthesis and Analysis
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Glycosylation and Glycoproteins Research
- Esophageal Cancer Research and Treatment
- Protease and Inhibitor Mechanisms
- Lung Cancer Research Studies
- Pluripotent Stem Cells Research
- Biomedical Ethics and Regulation
- Cellular Mechanics and Interactions
- Immunotherapy and Immune Responses
- Genetics and Neurodevelopmental Disorders
- Fibroblast Growth Factor Research
- Genomics, phytochemicals, and oxidative stress
- Metastasis and carcinoma case studies
- Enzyme Catalysis and Immobilization
- Physics and Engineering Research Articles
- 3D Printing in Biomedical Research
- Neuroendocrine Tumor Research Advances
- Esophageal and GI Pathology
- Digital Transformation in Industry
Fraunhofer Institute for Experimental Software Engineering
2024
Wageningen University & Research
2021
University of Oslo
2018-2020
Copenhagen University Hospital
2019-2020
University of Copenhagen
2019-2020
Oslo University Hospital
2020
StemCells (United States)
2020
University of Freiburg
2013-2019
University Medical Center Freiburg
2014-2017
University Medical Center
2015
Digital twins are virtual models of physical artefacts that may or not be synchronously connected, and can used to simulate their behavior. They widely in several domains such as manufacturing automotive enable achieving specific quality goals. In the health domain, so-called digital patient have been understood patients generated from population data and/or data, including, for example, real-time feedback wearables. Along with growing impact science technologies like artificial...
Esophageal cancers are highly aggressive tumors with poor prognosis despite some recent advances in surgical and radiochemotherapy treatment options. This study addressed the feasibility of drugs targeting epigenetic modifiers esophageal squamous cell carcinoma (ESCC) adenocarcinoma (EAC) cells. We tested inhibition histone deacetylases (HDACs) by SAHA, MS-275, FK228, DNA methyltransferases Azacytidine (AZA) Decitabine (DAC), effect combination using both types drugs. The drug targets,...
Diffuse gliomas are the most common primary malignant brain tumor. Although extracranial metastases rarely observed, recent studies have shown presence of circulating tumor cells (CTCs) in blood glioma patients, confirming that a subset capable entering circulation. The isolation and characterization CTCs could provide non-invasive method for repeated analysis mutational phenotypic state during course disease. However, efficient detection has proven to be challenging due lack consistently...
Small Cell Lung Cancer (SCLC) is a specific subtype of lung cancer presenting as highly metastatic disease with extremely poor prognosis. Despite responding initially well to chemo- or radiotherapy, SCLC almost invariably relapses and develops resistance chemotherapy. This suspected be related tumor cell subpopulations different characteristics resembling stem cells. Epithelial-Mesenchymal Transition (EMT) known play key role in processes developing drug resistance. also true for NSCLC, but...
Digital patient twins constitute a transformative innovation in personalized medicine, integrating patient-specific data into predictive models that leverage artificial intelligence (AI) to optimize diagnostics and treatments. However, existing digital often fail incorporate gender-sensitive socio-economic factors, reinforcing biases diminishing their clinical effectiveness. This (gender) gap, long recognized as fundamental problem health, translates significant disparities healthcare...
Fe(II)- and 2-oxoglutarate (2OG)-dependent JumonjiC domain-containing histone demethylases (JmjC KDMs) are "epigenetic eraser" enzymes involved in the regulation of gene expression emerging drug targets oncology. We screened a set clinically used iron chelators report that they potently inhibit JMJD2A (KDM4A) vitro. Mode action investigations revealed one compound, deferasirox, is bona fide active site-binding inhibitor as shown by kinetic spectroscopic studies. Synthesis derivatives with...
In cancer biology, the architectural concept “form follows function” is reflected by cell morphology, migration, and epithelial–mesenchymal transition protein pattern. vivo, features of have been associated with tumor budding, which correlates significantly patient outcome. Hereby, majority buds are not truly detached but still connected to a major mass. For detailed insights into different bud types process we quantified cells according histomorphological immunohistological characteristics....
Embryonic stem cell renewal and differentiation is regulated by metabolites that serve as cofactors for epigenetic enzymes. An increase of α-ketoglutarate (α-KG), a cofactor histone DNA demethylases, triggers multilineage in human embryonic cells (hESCs). To gain further insight into how the metabolic fluxes pluripotent can be influenced inactivating mutations enzymes, we generated hESCs deficient de novo methyltransferases (DNMTs) 3A 3B. Our data reveal bidirectional dependence between...
Chain elongation fermentation allows for the synthesis of biobased chemicals from complex organic residue streams. To expand product spectrum chain technology and its application range we investigated 1) how to increase selectivity towards branched 2) whether alternative carboxylates such as valerates can be used electron acceptors. Elongation isobutyrate 4-methyl-pentanoate was achieved with a 27% (of total products, based on carbon atoms) in continuous system that operated under CO 2...
Early detection and monitoring of cancer progression is key to successful treatment. Therefore, much research invested in developing technologies, enabling effective valuable use non-invasive liquid biopsies. This includes the analysis circulating tumor cells (CTCs) from blood samples. Recombinant malaria protein VAR2CSA (rVAR2) binds a unique chondroitin sulfate modification present on vast majority cancers thereby holds promise as near-universal cell-targeting reagent isolate CTCs complex...