A5012651970- Pharmacogenetics and Drug Metabolism
- Pancreatic and Hepatic Oncology Research
- Veterinary Pharmacology and Anesthesia
- Drug Transport and Resistance Mechanisms
- Cell Adhesion Molecules Research
- TGF-β signaling in diseases
- Anesthesia and Sedative Agents
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pharmacological Effects and Toxicity Studies
- Cancer Cells and Metastasis
- Protease and Inhibitor Mechanisms
- Pharmacology and Obesity Treatment
- Metabolism, Diabetes, and Cancer
- Antibiotics Pharmacokinetics and Efficacy
- Cancer Treatment and Pharmacology
- Epigenetics and DNA Methylation
- Diabetes Treatment and Management
- Muscle and Compartmental Disorders
- Treatment of Major Depression
- Peroxisome Proliferator-Activated Receptors
- Autoimmune Bullous Skin Diseases
- Dialysis and Renal Disease Management
- Inflammatory mediators and NSAID effects
- Pain Management and Opioid Use
- Malaria Research and Control
Nordic Bioscience (Denmark)
2022-2025
University of Copenhagen
2013-2025
Gentofte Hospital
2023
Karolinska University Hospital
2023
Copenhagen University Hospital
2019
Statens Serum Institut
2017
University of Southern Denmark
2005-2015
Karolinska Institutet
2008-2010
Institute for Biotechnology and Bioengineering
2010
University of Algarve
2010
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The only existing study of CYP2C19 * 17 ‐associated alterations in drug pharmacokinetics was retrospective and compared probe metabolic ratios. allele had been associated with a two‐ fourfold decrease omeprazole S/R ‐mephenytoin STUDY ADDS This characterized the single‐dose omeprazole, along 5‐hydroxy sulphone metabolites, 17/ 1/ 1 subjects. observed differences AUC ∞ suggest that is an important explanatory factor behind individual cases...
Abstract: Oxycodone is O‐demethylated by CYP2D6 to oxymorphone which a potent µ‐receptor agonist. The oxidation polymorphism divides the Caucasian population in two phenotypes: Approximately 8% with no enzyme activity, poor metabolizers (PM) and remainder preserved extensive (EM). objective of study was determine if analgesic effect oxycodone human experimental pain depends on its metabolism oxymorphone. evaluated randomized, placebo‐controlled, double‐blinded, crossover experiment including...
Objective The aim of this study was to determine the association between renal clearance (CLrenal) metformin in healthy Caucasian volunteers and single-nucleotide polymorphism (SNP) c.808G>T (rs316019) OCT2 as well relevance gene–gene interactions SNP (a) promoter g.-66T>C (rs2252281) MATE1 (b) OCT1 reduced-function diplotypes. Methods Fifty genotyped for were enrolled study. distribution 25 GG, 20 GT, 5 TT volunteers. pharmacokinetics a 500 mg single oral dose studied. Results When analyzed...
Diffuse gliomas are the most common primary malignant brain tumor. Although extracranial metastases rarely observed, recent studies have shown presence of circulating tumor cells (CTCs) in blood glioma patients, confirming that a subset capable entering circulation. The isolation and characterization CTCs could provide non-invasive method for repeated analysis mutational phenotypic state during course disease. However, efficient detection has proven to be challenging due lack consistently...
The use of novel tools to understand tumour-fibrosis in pancreatic ductal adenocarcinoma (PDAC) and anti-fibrotic treatments are highly needed. We established a pseudo-3D vitro model including humane fibroblasts (PFs) cancer-associated (CAFs) combination with clinical collagen biomarkers, as translational drug screening tool. Furthermore, we investigated the prognostic potential serum biomarkers 810 patients PDAC. PFs CAFs were cultured Ficoll-media. Cells treated w/wo TGF-ß1 compound ALK5i....
Objective Tramadol hydrochloride (INN, tramadol) exerts its antinociceptive action through a monoaminergic effect mediated by the parent compound and an opioid mainly O-demethylated metabolite (+)-M1. O-demethylation is catalyzed cytochrome P450 (CYP) 2D6. Paroxetine very potent inhibitor of CYP2D6. The objective this study was to investigate influence paroxetine pretreatment on biotransformation hypoalgesic tramadol. Methods With without (20 mg daily for 3 consecutive days), formation M1...
Journal Article Multivariate variance targeting in the BEKK–GARCH model Get access Rasmus S. Pedersen, Pedersen Department of Economics, University Copenhagen, Oester Farimagsgade 5, Building 26, DK‐1353 Copenhagen K, Denmark Search for other works by this author on: Oxford Academic Google Scholar Anders Rahbek DenmarkCenter Research Econometric Analysis Time Series, Economics and Business, Aarhus University, Fuglesangs Allé 4, DK‐8210 V, The Econometrics Journal, Volume 17, Issue 1, 1...
Background and Objective Polymorphic cytochrome P450 (CYP) 2D6 activity has been shown to be a determinant of the pharmacokinetics pharmacodynamics tramadol via hepatic phase I O-demethylation (+)-tramadol (+)-O-desmethyltramadol. Our objective was investigate whether can used as probe for CYP2D6 phenotyping by determining concordance between 8-hour 12-hour sparteine metabolic urinary ratios. Methods Sparteine test carried out in 278 healthy, white subjects. At minimum 2 weeks later, each...
Cytochrome P4502C19 (CYP2C19) is an important drug-metabolizing enzyme involved in the biotransformation of, for example, proton pump inhibitors and antidepressants. Several vivo studies have shown that CYP2C19 activity inhibited by oral contraceptives, which can cause drug interactions. The underlying molecular mechanism has been suggested to be competitive inhibition. However, results presented here indicate estradiol derivatives down-regulate expression via estrogen receptor (ER) α,...
Abstract Background Collagens are the major components of extracellular matrix (ECM) and known to contribute tumor progression metastasis. There 28 different types collagens each with unique functions in maintaining tissue structure function. Type XVII collagen (BP180) is a type II transmembrane protein that provides stable adhesion between epithelial cells underlying basement membrane. Aberrant expression ectodomain shedding have been associated damage, invasiveness, metastasis multiple may...
Our objective was to investigate the steady-state pharmacokinetic and pharmacodynamic interaction between antidepressive herbal medicine St John's wort antidiabetic drug metformin.We performed an open cross-over study in 20 healthy male subjects, who received 1 g of metformin twice daily for week with without 21 days preceding concomitant treatment wort. The pharmacokinetics determined, a 2 h oral glucose tolerance test performed.St decreased renal clearance but did not affect any other...
ABSTRACT: Global arthropod populations are changing due to the combined impacts of climate change, land-use transformation, globalisation and trade. These changes can potentially result in decline extinction some native and/or endemic species, while other species that pose threats human animal may increase. Such dynamics lead weakened ecosystem resilience, which facilitate establishment spread with vector capacities, such as mosquitoes. While many mosquito present Ireland possess have not...
Abstract The extracellular matrix (ECM) protein Beta-Ig H3 (βigH3, also known as transforming growth factor β induced (TGFBI)) is related to poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC). Proteolytic cleavage of βigH3 has been shown result release the N-terminal fragment covering amino acid 1 137, but whether degradation associated yet be determined. In this study we developed an ELISA targeting a collagenase generated (cβigH3) human serum use biomarker reflecting...
To determine the effect of CYP2C8 genotype and fluvoxamine on pharmacokinetics rosiglitazone.Twenty-three healthy subjects with following genotypes were included in a two-phase, open-label, cross-over trial: CYP2C8*3/ *3 (n = 3), CYP2C8*1/ 10) *1 10). In Phase A, given 4 mg rosiglitazone as single oral dose. B, treated multiple doses 50 maleate for 3 days prior to administration rosiglitazone. Plasma concentrations relative amounts N-desmethylrosiglitazone measured both phases 24 h after...
Fibroblast activation protein (FAP) is a known promoter of tumor development and associated with poor clinical outcome for various cancer types. Being specifically expressed in pathological conditions including multiple types fibrosis cancers, FAP an optimal target diagnostics treatment. Treatment strategies utilizing the unique proteolytic activity are emerging, thus emphasizing importance biomarkers to directly assess activity. type II transmembrane serine protease that has been shown...
CYP2C9 is an important drug-metabolizing enzyme that metabolizes, e.g., warfarin, antidiabetics, and antiphlogistics. However, the endogenous regulation of this largely unknown. In study, we examined role GATA transcription factors in gene expression <i>CYP2C9</i>. We investigated four putative binding sites within first 200 base pairs <i>CYP2C9</i> promoter at positions I: −173/−170, II: −167/−164, III: −118/−115, IV: −106/−103. Luciferase activity driven by a wild-type construct was...
The aim of this study was to determine the intrapair similarity in trough steady-state plasma concentrations metformin monozygotic and dizygotic twin pairs.We included 16 pairs (eight eight pairs) for after contacting 524 pairs. They were dosed with steady state (1 g twice daily) 6 days on day 7, concentration determined 12 h last dose.There no strong either or pairs.The does not appear be tightly genetically regulated. interpretation finding is limited by small sample size.