A5034309523- Muscle Physiology and Disorders
- Nutrition and Health in Aging
- Muscle metabolism and nutrition
- Muscle activation and electromyography studies
- Diabetes and associated disorders
- Body Composition Measurement Techniques
- Cardiomyopathy and Myosin Studies
- Diet and metabolism studies
- Cardiovascular and exercise physiology
- Pancreatic function and diabetes
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Diabetes Management and Research
- Knee injuries and reconstruction techniques
- Hormonal and reproductive studies
- Sports Performance and Training
- Menopause: Health Impacts and Treatments
- Flexible and Reconfigurable Manufacturing Systems
- Obesity, Physical Activity, Diet
- Ovarian function and disorders
- Regulation of Appetite and Obesity
- Cardiac Health and Mental Health
- Sports injuries and prevention
- Diet, Metabolism, and Disease
- Quality and Supply Management
University of Vermont
2016-2025
Fort Worth Library
2024
University of Florida
2024
Hospital Civil de Guadalajara
2023
University of South Florida
2019-2022
Pacific Northwest Diabetes Research Institute
2022
Leavitt Partners (United States)
2021
Bochum University of Applied Sciences
2015-2020
Georgia Institute of Technology
2015-2017
University of Massachusetts Amherst
2016
To describe the effects of menopause on resting metabolic rate, body composition, fat distribution, physical activity during leisure time, and fasting insulin levels.A longitudinal comparison changes in women who experienced with age-matched did not experience menopause.General clinical research center.An initial cohort 35 sedentary healthy premenopausal (age range, 44 to 48 years). After 6 years follow-up, 18 had spontaneously stopped menstruating for at least 12 months 17 remained...
This European Respiratory Society (ERS) statement provides a comprehensive overview on physical activity in patients with chronic obstructive pulmonary disease (COPD). A multidisciplinary Task Force of experts representing the ERS Scientific Group 01.02 “Rehabilitation and Chronic Care” determined overall scope this through consensus. Focused literature reviews were conducted key topic areas final content Statement was agreed upon by all members. The current knowledge regarding COPD is...
OBJECTIVE—We examined the hypothesis that an age-related increase in compartments of visceral fat would account, part, for deleterious changes insulin sensitivity and blood lipid profile nonobese women. RESEARCH DESIGN AND METHODS—We directly assessed subcutaneous abdominal adipose tissue areas (computed tomography), glucose disposal (hyperinsulinemic-euglycemic clamp), body composition (dual energy X-ray absorptiometry), blood-lipid profile, aerobic fitness (Vo2max) 178 women categorized...
More than 80% of patients entering cardiac rehabilitation (CR) are overweight, and >50% have metabolic syndrome. Current CR exercise protocols result in little weight loss minimal changes risk factors. We sought to design an protocol that would lead greater factor change.We performed a randomized controlled clinical trial evaluate the effect high-calorie-expenditure (3000- 3500-kcal/wk exercise-related energy expenditure) compared with standard (7 800 kcal/wk) on factors 74 overweight...
We hypothesize that age-related skeletal muscle dysfunction and physical disability may be partially explained by alterations in the function of myosin molecule. To test this hypothesis, at whole muscle, single fiber, molecular levels was measured young (21–35 yr) older (65–75 male female volunteers with similar activity levels. After adjusting for size, adults had knee extensor isometric torque values compared young, but lower isokinetic power, most notably women. At single-fiber levels,...
How breast cancer and its treatments affect skeletal muscle is not well defined. To address this question, we assessed structure protein expression in 13 women who were diagnosed with receiving adjuvant chemotherapy following tumor resection 12 nondiseased controls. Breast patients showed reduced single-muscle fiber cross-sectional area fractional content of subsarcolemmal intermyofibrillar mitochondria. Drugs commonly used (doxorubicin paclitaxel) caused reductions myosin expression,...
Peak O2 uptake (VO2) has traditionally been compared among individuals differing in body composition by dividing measured values (1/min) fat-free mass (FFM) (i.e., ratio method). However, the ability of method to mathematically remove confounding influence FFM from peak VO2 recently questioned. Therefore, we effectiveness vs. regression modeling normalize a large cohort males and females for differences FFM. Regression adjusts according relationship derived on Results showed that was 60%...
Aging is associated with decreased skeletal muscle mass and function. These changes are thought to derive, in part, from a reduction protein synthesis. Although some studies have shown reduced postabsorptive synthesis age humans, recent failed find an effect. In addition this disparity, few attempted characterize the hormonal factors that may contribute Thus we examined effect of on metabolism, specific emphasis myosin heavy chain (MHC) protein, relationship rates plasma hormone levels. We...
Previous studies have suggested that elevated resting energy expenditure contributes to weight loss in patients with Parkinson9s disease (PD).Body is, however, ultimately determined by variation daily and not just expenditure. Therefore, we examined the hypothesis PD are characterized Sixteen levodopa responsive 46 healthy elderly controls were for its components (resting physical activity expenditure) using a combination of doubly labeled water technique (over 10 days) indirect calorimetry....
Data-independent tandem mass spectrometry isolates and fragments all of the molecular species within a given mass-to-charge window, regardless whether precursor ion was detected window. For shotgun proteomics on complex protein mixtures, data-independent MS/MS offers certain advantages over traditional data-dependent MS/MS: identification low-abundance peptides with insignificant peaks, more direct relative quantification, free biases caused by competing precursors dynamic exclusion, faster...
We examined the contribution of variations in body composition and leisure time physical activity to age-related decline peak oxygen consumption (VO2) men women. Healthy males 17–80 yr old (n = 378) females 18–81 224) were characterized for VO2 from a treadmill test exhaustion, fat-free mass fat by underwater weighing, activity. Peak showed greater absolute (P < 0.05) with age (r -0.70, slope -0.034 l.min-1.yr-1; P 0.01) than -0.78, -0.028 0.01). After statistically controlling...
<h3>Background:</h3> Increasing levels of total and central body fat with advancing age contribute to the development cardiovascular metabolic disease. We examined gender-related differences physiological predictors rate increase in men women. <h3>Methods:</h3> studied 427 healthy (age range, 17 90 years) 293 women 18 88 years). measured fatness by hydrostatic weighing, adiposity from waist circumference, peak volume oxygen utilization (V̇O<sub>2</sub>) a treadmill test, leisure time...
Purpose: After menopause, women gain abdominal fat and become less sensitive to insulin. We sought determine whether hormone replacement therapy (HRT) reduced intraabdominal sc improved insulin sensitivity in early menopausal women.
Purpose: Patients with chronic heart failure (CHF) report difficulty performing activities of daily living. To our knowledge, however, no study has directly measured performance in living these patients to systematically assess their level physical disability. Moreover, the contribution skeletal muscle weakness disability CHF remains unclear. Thus, we and controls, its relationship aerobic capacity strength, effect resistance exercise training improve strength Methods: controls were assessed...
Age-related loss of skeletal muscle mass and function is implicated in the development disease physical disability. However, little known about how age affects structure at cellular ultrastructural levels or such alterations impact function. Thus we examined tissue, cellular, myofibrillar young (21–35 yr) older (65–75 male female volunteers, matched for habitual activity level. Older adults had smaller whole tissue cross-sectional areas (CSAs) mass. At level, reduced CSAs myosin heavy chain...
In Brief PURPOSE: The value of exercise and rehabilitative interventions for cancer survivors is increasingly clear, oncology rehabilitation programs could provide these important interventions. However, a pathway to create has not been delineated. Community-based cardiac (CR) staffed by health care professionals with experience in providing secondary prevention services individuals coronary heart disease are widely available potential model location programs. Our purpose was outline the...
Skeletal muscle contractile performance is governed by the properties of its constituent fibers, which are, in turn, determined molecular interactions myofilament proteins. To define determinants function humans, we measured mechanics during maximal Ca 2+ -activated and passive isometric conditions single fibers with homogenous (I IIA) mixed (I/IIA IIA/X) myosin heavy chain (MHC) isoforms from healthy, young adult male ( n = 5) female 7) volunteers. Fibers containing only MHC II (IIA...
Background: Anterior cruciate ligament (ACL) injuries and reconstruction (ACLR) promote quadriceps muscle atrophy weakness that can persist for years, suggesting the need more effective rehabilitation programs. Whether neuromuscular electrical stimulation (NMES) be used to prevent maladaptations in skeletal size function is unclear. Purpose: To examine whether early NMES use, started soon after an injury maintained through 3 weeks surgery, preserve contractile at cellular (ie, fiber) level...
Prior studies suggest that estradiol and progesterone regulate body composition in growing female rats. Because these did not consider the confounding effect of changes food intake, it remains unclear whether ovarian hormones independently their effects on intake. We utilized a pair-feeding paradigm to examine composition. In addition, skeletal muscle protein fractional synthesis rate adipose tissue lipoprotein lipase activity were measured pathways substrate deposition into fat fat-free...