A5102982678- Parasitic Diseases Research and Treatment
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Extracellular vesicles in disease
- Asthma and respiratory diseases
- Insect symbiosis and bacterial influences
National Institute of Allergy and Infectious Diseases
2023-2024
National Institutes of Health
2023-2024
The immunologic mechanisms underlying pulmonary type 2 inflammation, including the dynamics of eosinophil recruitment to lungs, still need be elucidated.We sought investigate how IL-13-producing TH2 effector cells trigger migration in house dust mite (HDM)-driven allergic inflammation.Multiparameter and molecular profiling murine lungs with HDM-induced allergy was investigated absence IL-13 signaling by using IL-13Rα1-deficient mice separately through adoptive transfer CD4+ T from...
Introduction Live microfilariae (mf) and mf-derived extracellular vesicles (EVs) have been shown to modulate human antigen presenting cell (APC) function, most notably by suppressing the induction of IL-12 (and other pro-inflammatory cytokines) following activation with LPS interferon-y. Methods To explore further how EVs alter APC we studied effect mf on elutriated monocyte-derived dendritic cells (DC) exposure Mf, excretory/secretory (E/S) products, E/S depleted through ultracentrifugation...