A5087935640- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- High Altitude and Hypoxia
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Adenosine and Purinergic Signaling
- Cancer Immunotherapy and Biomarkers
- Inflammatory Bowel Disease
- Metabolomics and Mass Spectrometry Studies
- Neonatal Health and Biochemistry
- Pneumocystis jirovecii pneumonia detection and treatment
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Exercise and Physiological Responses
- Colorectal Cancer Treatments and Studies
- Barrier Structure and Function Studies
- Renal Transplantation Outcomes and Treatments
University College Dublin
2016-2020
Sigmoid Pharma (Ireland)
2016-2019
Dublin City University
2016-2019
The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen-dependence upon the hypoxia-inducible (HIF), a master regulator of cellular adaptive response to hypoxia. Studies investigating whether hydroxylation is general regulatory oxygen-dependent modification have identified multiple non-HIF targets for FIH. However, functional consequences this outside pathway remain unclear. Here, we demonstrate that deubiquitinase ovarian tumor domain containing ubiquitin aldehyde binding...
The HIF hydroxylase enzymes (PHD1-3 and FIH) are cellular oxygen-sensors which confer hypoxic-sensitivity upon the hypoxia-inducible factors HIF-1α HIF-2α. Microenvironmental hypoxia has a strong influence on epithelial immune cell function through HIF-dependent gene expression consequently impacts course of disease progression in ulcerative colitis (UC), with being protective while HIF-2α promotes disease. However, little is known about how inflammation regulates hypoxia-responsive pathways...
Abstract Background When an immune cell migrates from the bloodstream to a site of chronic inflammation, it experiences profound decrease in microenvironmental oxygen levels leading state cellular hypoxia. The hypoxia‐inducible factor‐1α ( HIF ‐1α) promotes adaptive transcriptional response hypoxia and as such is major regulator survival function. hydroxylases are family oxygen‐sensing enzymes primarily responsible for conferring dependence upon pathway. Methods Using mouse model allergic...
Inflammatory bowel disease (IBD) is characterized by epithelial barrier dysfunction with resultant inflammation as the mucosal immune system becomes exposed to luminal antigens. The hydroxylase inhibitor dimethyloxalylglycine (DMOG) reduces symptoms in experimental colitis through upregulation of genes promoting function and inhibition cell apoptosis. immunosuppressive drug cyclosporine associated IBD via suppression activation. Given distinct protective effect DMOG anti-inflammatory...
Hypoxia is a common and prominent feature of the microenvironment at sites bacteria-associated inflammation in inflammatory bowel disease. The prolyl-hydroxylases (PHD1/2/3) asparaginyl-hydroxylase factor-inhibiting HIF are oxygen-sensing enzymes that regulate adaptive responses to hypoxia through controlling activity NF-κB-dependent transcriptional pathways. Previous studies have demonstrated pan-hydroxylase inhibitor dimethyloxalylglycine (DMOG) effective alleviation preclinical models...
Hypoxia is a feature of inflammation. Recent research into the protective role prolyl-hydroxylase inhibitors in animal models ulcerative colitis has suggested hypoxia and HIF pathway may be involved UC. In hypoxic conditions, stabilised initiates transcription genes critical to adaptation hypoxia. this study, we investigate tissue transcriptional activity colitis. Healthy control (n = 7) patients 41) were prospectively recruited. Tissue oximetry was used during endoscopy procedures assess...