A5041795578- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced X-ray and CT Imaging
- Radiopharmaceutical Chemistry and Applications
- Radiation Dose and Imaging
- MRI in cancer diagnosis
- Lung Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Radiation Detection and Scintillator Technologies
- Cancer, Hypoxia, and Metabolism
- Particle physics theoretical and experimental studies
- Renal cell carcinoma treatment
- Ultrasound and Hyperthermia Applications
- Quantum Chromodynamics and Particle Interactions
- Atomic and Subatomic Physics Research
- Prostate Cancer Treatment and Research
- Dark Matter and Cosmic Phenomena
- Endometrial and Cervical Cancer Treatments
- Lanthanide and Transition Metal Complexes
- Prostate Cancer Diagnosis and Treatment
- Nuclear Materials and Properties
- Photoacoustic and Ultrasonic Imaging
Washington University in St. Louis
2022-2025
Mallinckrodt (United States)
2024-2025
University of Michigan
2018-2024
Michigan United
2021-2022
Michigan Medicine
2016-2022
The University of Texas MD Anderson Cancer Center
2008-2018
University of Houston
2014-2016
Thomas Jefferson University
2015
Christiana Hospital
2012-2015
Varian Medical Systems (United States)
2015
The deterministic Acuros XB (AXB) algorithm was recently implemented in the Eclipse treatment planning system. goal of this study to compare AXB performance Monte Carlo (MC) and two standard clinical convolution methods: anisotropic analytical (AAA) collapsed-cone (CCC) method.Homogeneous water multilayer slab virtual phantoms were used for study. phantom had three different materials, representing soft tissue, bone, lung. Depth dose lateral profiles from v10 compared AAA Eclipse, CCC...
Purpose: The novel deterministic radiation transport algorithm, Acuros XB (AXB), has shown great potential for accurate heterogeneous dose calculation. However, the clinical impact between AXB and other currently used algorithms still needs to be elucidated translation these algorithms. purpose of this study was investigate calculation in lung cancer intensity‐modulated therapy (IMRT) volumetric‐modulated arc (VMAT). Methods: thorax phantom from Radiological Physics Center (RPC) study. IMRT...
Purpose: The purpose of this study was to verify the dosimetric performance Acuros XB (AXB), a grid‐based Boltzmann solver, in intensity‐modulated radiation therapy (IMRT) and volumetric‐modulated arc (VMAT). Methods: Radiological Physics Center (RPC) head neck (H&N) phantom used for all calculations measurements study. Clinically equivalent IMRT VMAT plans were created on RPC H&N Eclipse treatment planning system (version 10.0) by using dose prescription specifications....
We report a new measurement of the parity-violating asymmetry in elastic electron scattering from proton at backward angles. This is sensitive to strange magnetic form factor as well electroweak axial radiative corrections. The A = -4.92+/-0.61+/-0.73 ppm provides significant constraint on these quantities. implications for are discussed context theoretical estimates
To assess differences between four different voxel-based dosimetry methods (VBDM) for tumor, liver, and lung absorbed doses following (90)Y microsphere selective internal radiation therapy (SIRT) based on bremsstrahlung SPECT/CT, a secondary objective was to estimate the sensitivity of liver due in organ segmentation near liver-lung interface.Investigated VBDM were Monte Carlo (MC), soft-tissue kernel with density correction (SKD), (SK), local deposition (LD). Seventeen SIRT cases analyzed....
A major toxicity concern in radioembolization therapy of hepatic malignancies is radiation-induced pneumonitis and sclerosis due to hepatopulmonary shunting 90Y microspheres. Currently, 99mTc macroaggregated albumin (99mTc-MAA) imaging used estimate the lung shunt fraction (LSF) prior treatment. The aim this study was evaluate accuracy/precision LSF estimated from planar SPECT/CT phantom imaging, within context, compare corresponding lung-absorbed dose values 99mTc-MAA patient studies....
To develop a practical background compensation (BC) technique to improve quantitative (90)Y-bremsstrahlung single-photon emission computed tomography (SPECT)/computed (CT) using commercially available imaging system.All images were acquired medium-energy collimation in six energy windows (EWs), ranging from 70 410 keV. The EWs determined based on the signal-to-background ratio planar of an acrylic phantom different thicknesses (2-16 cm) positioned below (90)Y source and set at distances...
The aim of this work was to develop models for tumor control probability (TCP) in radioembolization with <sup>90</sup>Y PET/CT–derived radiobiologic dose metrics. <b>Methods:</b> Patients primary liver cancer or metastases who underwent glass microspheres were imaged PET/CT voxel-level dosimetry determine lesion absorbed (AD) metrics, biological effective (BED) equivalent uniform dose, and BED 28 treatments (89 lesions). dose–shrinkage correlation assessed on the basis RECIST and, when...
We report the first measurement of vector analyzing power in inclusive transversely polarized elastic electron-proton scattering at Q2=0.1(GeV/c)2 and large angles. This quantity must vanish single virtual photon exchange, plane-wave impulse approximation for this reaction, can therefore provide information on two exchange amplitudes electromagnetic interactions with hadronic systems. The observable we have measured is driven by imaginary part amplitude, side which simply Compton amplitude...
Patient-specific dosimetry in radiopharmaceutical therapy (RPT) is impeded by the lack of tools that are accurate and practical for clinic. The aims were to construct test an integrated voxel-level pipeline automates key components (organ segmentation, registration, dose-rate estimation, curve fitting) RPT process then use it report patient specific 177Lu-DOTATATE therapy. Methods: An workflow entire process, except tumor was constructed. 1) Convolutional neural networks (CNNs) used...
Purpose: To evaluate the dose distributions of an source (model VS2000) in homogeneous water geometry calculated using a deterministic grid‐based Boltzmann transport equation solver (GBBS) commercial treatment planning system (TPS) ( BRACHYVISION‐ACUROS v8.8). Methods: Using percent differences , GBBS (BV‐ ACUROS ) was compared to (1) published TG‐43 data, (2) MCNPX Monte Carlo (MC) simulations centered 15 cm radius sphere, and (3) output from TPS vendor supplied (BV‐TG43‐vendor) user...
The aims of this study were to evaluate the effects noise, motion blur, and compensation using quiescent-period gating (QPG) on activity concentration (AC) distribution-quantified cumulative AC volume histogram (ACVH)-in count-limited studies such as 90Y-PET/CT. An International Electrotechnical Commission phantom filled with low 18F was used simulate clinical 90Y-PET images. PET data acquired a GE-D690 when static subject 1-4 cm periodic 1D motion. down-sampled into shorter durations...
Objective.90Y selective internal radiation therapy (SIRT) treatment of hepatocellular carcinoma (HCC) can potentially underdose lesions, as identified on post-therapy PET/CT imaging. This study introduces a methodology and explores the feasibility for selectively treating SIRT-underdosed HCC or lesion subvolumes, with stereotactic body (SBRT) following post-SIRT dosimetry.Approach. We retrospectively analyzed post-treatment images 20 patients after90Y SIRT. Predicted tumor response from SIRT...
Current methods for patient-specific voxel-level dosimetry in radionuclide therapy suffer from a trade-off between accuracy and computational efficiency. Monte Carlo (MC) radiation transport algorithms are considered the gold standard but can be computationally expensive, whereas faster dose voxel kernel (DVK) convolution suboptimal presence of tissue heterogeneities. Furthermore, accuracies both these limited by spatial resolution reconstructed emission image. To overcome limitations, this...
The aim was to quantify inter- and intra-observer variability in manually delineated hepatocellular carcinoma (HCC) lesion contours the resulting impact on radioembolization (RE) dosimetry.Ten patients with HCC lesions treated Y-90 RE imaged post-therapy PET/CT were selected for retrospective analysis. Three radiologists contoured 20 baseline multiphase contrast-enhanced MRIs, two of re-contoured at additional sessions. Contours transferred co-registered PET/CT-based dose maps....
Validation of dosimetry software, such as Monte Carlo (MC) radiation transport codes used for patient-specific absorbed dose estimation, is critical prior to their use in clinical decision making. However, direct experimental validation the clinic generally not performed low/medium-energy beta emitters radiopharmaceutical therapy (RPT) due challenges measuring energy deposited by short-range particles. Our objective was design a practical phantom geometry radiochromic film (RF)-based...
With recent interest in patient-specific dosimetry for radiopharmaceutical therapy (RPT) and selective internal radiation (SIRT), an increasing number of voxel-based algorithms are being evaluated. Monte Carlo (MC) transport, generally considered to be the most accurate among different methods voxel-level absorbed dose estimation, can computationally inefficient routine clinical use.
Functional liver parenchyma can be damaged from treatment of malignancies with