A5012040065- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrest and Resuscitation
- Organ Transplantation Techniques and Outcomes
- Neonatal Respiratory Health Research
- Cardiac, Anesthesia and Surgical Outcomes
- Childhood Cancer Survivors' Quality of Life
- Sepsis Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Antifungal resistance and susceptibility
- Central Venous Catheters and Hemodialysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nosocomial Infections in ICU
- Viral Infections and Immunology Research
- Heart Failure Treatment and Management
- Child and Adolescent Health
- Metabolism and Genetic Disorders
- Muscle and Compartmental Disorders
- Healthcare Systems and Practices
- Sarcoidosis and Beryllium Toxicity Research
- Medical Malpractice and Liability Issues
- Antibiotic Use and Resistance
Birmingham Children's Hospital
2014-2024
Birmingham Women’s and Children’s NHS Foundation Trust
2018-2023
Trinity College Dublin
2019
Freeman Hospital
2002-2013
Newcastle upon Tyne Hospitals NHS Foundation Trust
2007-2013
Newcastle upon Tyne Hospital
2006-2010
Royal College of Paediatrics and Child Health
2009
University College London
2004-2009
Glenfield Hospital
2004-2009
Royal Hospital for Children
2004-2009
Background Bloodstream infections from central venous catheters (CVC-BSIs) increase morbidity and costs in intensive care units (ICUs). Substantial reductions CVC-BSI rates have been reported using a combination of technical non-technical interventions. Methods We conducted 2-year, four-cluster, stepped non-randomised study (behavioural) interventions to prevent CVC-BSIs adult paediatric ICUs England. Random-effects Poisson regression modelling was used compare infection rates. A sample...
We report the development of a severe polyneuropathy in 4 38 patients who were receiving parenteral suramin therapy for treatment various underlying malignancies. In 2 these patients, neuropathy progressed to generalized flaccid paralysis with bulbar and respiratory involvement, requiring endotracheal intubation ICU monitoring. EMG nerve conduction studies showed evidence block, suggestive demyelinating polyneuropathy. After several weeks, both improved clinically. The other developed...
Given excellent 30-day survival for pediatric cardiac surgery, other outcome measures are important. We aimed to study important early postoperative morbidities selected by stakeholders following a rigorous and evidenced-based process, with view identifying potential risk factors.The incidence of was prospectively measured 3090 consecutive surgical admissions in 5 UK centers between October 2015 June 2017. The relationship the candidate factors explored using multiple regressions. Patient...
To review the UK neonatal extracorporeal membrane oxygenation (ECMO) service and identify predictors of outcome.Retrospective national cohort.718 neonates received ECMO for respiratory failure between 1993 2005.Diagnoses were: 48.0% meconium aspiration syndrome (97.1% survivors), 15.9% congenital diaphragmatic hernia (CDH; 57.9% sepsis (62.3% 9.5% persistent pulmonary hypertension (79.4% 5.6% distress (92.5% survivors) 5.1% lung abnormalities (24.3% survivors). The overall survival rate...
To compare national neonatal extracorporeal membrane oxygenation data and deaths from primary respiratory disorders of term neonates between the United Kingdom States 1999 to 2005.Cross-sectional study.National sets States.Neonatal patients submitted Extracorporeal Life Support Organization Registry birth death registrations.None.Meconium aspiration syndrome was most common indication for in Kingdom: 50.6% vs. 25.8% (p < .001). Congenital diaphragmatic hernia States: 30.7% 15.4%...
Given the current excellent early mortality rates for paediatric cardiac surgery, stakeholders believe that this important safety outcome should be supplemented by a wider range of measures. Our objectives were to prospectively measure incidence morbidities following surgery and evaluate their clinical health-economic impact over 6 months.The design was prospective, multicentre, multidisciplinary mixed methods study.The setting 5 10 centres in UK with 21 months recruitment.Included 3090...
Survival following cardiac transplantation in infancy has improved substantially. There is a growing shortage of donors, the impact which may be offset by increase ABO-incompatible transplants, size-mismatching and mechanical support. The authors reviewed their results outcomes infant listing for over 22 years.Children <12 months at time transplant 1987-2008 were identified using departmental cardiopulmonary database. Details obtained from databases hospital medical records subdivided into...
Mechanical circulatory support (MCS) may be required after orthotopic heart transplantation (OHTx) in children for the treatment of failure or rejection. We review incidence and outcomes post-transplant MCS our institution. was classified as early (<1 month since transplant) late (>1 offered either veno-arterial extra-corporeal membrane oxygenation (VA-ECMO) a ventricular assist device (VAD). From 2003 to present, 100 (<16 years) underwent OHTx. Fifteen (15%) had 17 episodes MCS. instituted...
Internationally, the number of donors for cardiac transplantation has remained static, while patients requiring congenital heart disease (CHD) increased. Although availability mechanical circulatory support (MCS) may increase transplants performed by reducing deaths waiting, it also lead to increased morbidity post-transplantation. We sought assess impact on post-transplant outcomes in a single centre.We assessed paediatric (age ≤16 years) unit era (1998-2012) retrospective cohort study....
The aim of this study was to assess the safety and efficacy long-term milrinone therapy in children with acute decompensated heart failure due dilated cardiomyopathy (DCM).A single-centre retrospective all ≤18 years DCM who received continuous (≥7 consecutive days) intravenous between January 2008 2022.The 47 patients had a median age 3.3 months [interquartile range (IQR) 1.0-18.1], weight 5.7 kg [IQR 4.3-10.1] fractional shortening 11.9% [±4.7]. Idiopathic (n = 19) myocarditis 18) were most...
Healthcare-associated infections (HCAIs) are a major cause of morbidity and mortality in critically ill children. Data from adult studies suggest Selective Decontamination the Digestive tract (SDD) may reduce incidence HCAIs improve survival. There no data randomised clinical trials paediatric setting. An open label, parallel group pilot cRCT mixed-methods perspectives study was conducted six intensive care units (PICUs) England. Participants were children (> 37 weeks corrected gestational...
Background Over 5000 paediatric cardiac surgeries are performed in the UK each year and early survival has improved to > 98%. Objectives We aimed identify surgical morbidities that present greatest burden for patients health services develop pilot routine monitoring feedback. Design setting Our multidisciplinary mixed-methods study took place over 52 months across five surgery centres. Participants The participants were children aged < 17 years. Methods reviewed existing literature,...