A5065395295- Skin and Cellular Biology Research
- Dermatological and Skeletal Disorders
- Autoimmune Bullous Skin Diseases
- Cell Image Analysis Techniques
- Computational Drug Discovery Methods
- Cellular Mechanics and Interactions
- Silk-based biomaterials and applications
- Gene expression and cancer classification
- Advanced Biosensing Techniques and Applications
- Genetics, Bioinformatics, and Biomedical Research
- Celiac Disease Research and Management
- Metabolomics and Mass Spectrometry Studies
- Bioinformatics and Genomic Networks
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
2021-2025
Universidad Carlos III de Madrid
2023-2025
Centre for Biomedical Network Research on Rare Diseases
2021-2025
Hospital Universitario Fundación Jiménez Díaz
2023-2025
Universidad Complutense de Madrid
2025
Instituto de Salud Carlos III
2023-2024
Unidades Centrales Científico-Técnicas
2021
Bioengineering Center
2021
Drug discovery and development remains a complex time-consuming process, often hindered by high costs low success rates. In the big data era, artificial intelligence (AI) has emerged as promising tool to accelerate optimize these processes, particularly in field of oncology. This review explores application AI-based methods for drug repurposing natural product-inspired design cancer, focusing on their potential address challenges limitations traditional approaches. We delve into various...
We introduce drexml, a command line tool and Python package for rational data-driven drug repurposing. The employs machine learning mechanistic signal transduction modelling to identify targets capable of regulating particular disease. In addition, it explainability tools contextualize potential within the functional landscape methodology is validated in Fanconi Anemia Familial Melanoma, two distinct rare diseases where there pressing need solutions. case, model successfully predicts...
Recessive dystrophic epidermolysis bullosa (RDEB) is a blistering genodermatosis due to biallelic loss-of-function variants in the type VII collagen (C7) gene (COL7A1). We report impact of inflammation/autoimmunity on gut (and other organs) nine children with RDEB recruited an early-phase clinical trial systemic cell therapy (NCT04153630). This pilot study provides evidence that autoimmunity may play important role sustaining chronic inflammation and coexistence coeliac disease, which, turn,...