A5100668725- Endoplasmic Reticulum Stress and Disease
- Natural product bioactivities and synthesis
- Autophagy in Disease and Therapy
- Cardiac Ischemia and Reperfusion
- Chemotherapy-induced cardiotoxicity and mitigation
- Phytochemistry and Biological Activities
- Cardiovascular Function and Risk Factors
- Bioactive natural compounds
- Cell death mechanisms and regulation
- Ginseng Biological Effects and Applications
- Inflammasome and immune disorders
- Traditional Chinese Medicine Analysis
- Mitochondrial Function and Pathology
- Electron Spin Resonance Studies
- Medicinal Plants and Bioactive Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Hematological disorders and diagnostics
- Sirtuins and Resveratrol in Medicine
- Gut microbiota and health
- Plant-based Medicinal Research
- Extracellular vesicles in disease
- Genomics, phytochemicals, and oxidative stress
- Drug-Induced Ocular Toxicity
- Phytochemical Studies and Bioactivities
- Chromatography in Natural Products
Southern University of Science and Technology
2025
Jinan University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2017-2024
National Medical Products Administration
2022-2024
Ministry of Education of the People's Republic of China
2019-2024
Institute of Medicinal Plant Development
2016
Peking Union Medical College Hospital
2015-2016
Academy of Medical Sciences
2016
China Academy of Chinese Medical Sciences
2015-2016
Abstract Background : Recent reports suggested the involvement of oxidative stress- and endoplasmic reticulum stress (ERS)-associated pathways in progression ischemia/reperfusion (I/R) injury. Notoginsenoside R1 (NGR1) is a novel saponin isolated from P. notoginseng , which has history prevention treatment cardiovascular diseases. Objective We aimed to examine cardioprotective effects NGR1 on I/R-induced heart dysfunction ex vivo vitro. Methods H9c2 cadiomyocytes were incubated with for 24 h...
Reperfusion therapy is widely utilized for acute myocardial infarction (AMI), but further injury induced by rapidly initiating reperfusion of the heart often encountered in clinical practice. Ginsenoside RK3 (RK3) reportedly present processed Radix notoginseng that used as a major ingredient compound preparation ischemic diseases. This study aimed to investigate possible protective effect against hypoxia-reoxygenation (H/R) H9c2 cardiomyocytes damage and its underlying mechanisms. Our...
Background: Scutellarin (Scu) shows both anti-inflammatory and antioxidant activities. The study investigates cardioprotective effects of Scu in mice with type 1 diabetes the underlying molecular mechanism.Methods: Streptozotocin (STZ) was used to induce diabetic cardiomyopathy (DCM) C57BL/6 by intraperitoneal injection (i.p.). Normal were divided into 6 groups: control, model group (DM), DM + (5 mg/kg), (10 (20 pioglitazone (Pio) mg/kg). administered intraperitoneally Pio administrated...
Background The inflammatory response is a key factor in the pathogenesis of cerebral ischemia/reperfusion injury (CIRI), and anti-inflammatory interventions may offer promising therapeutic strategy. Forsythoside B (FB) phenylethanoid glycoside isolated from Forsythiae fructus, which has been reported to have effects. However, mechanism neuroprotective effect FB on CIRI remains unclear. Methods Adult male Sprague-Dawley rats were subjected transient middle artery occlusion/reperfusion...
<italic>Salvia miltiorrhiza Bunge</italic> is a well-known medicinal plant in China.
Effective strategies are dramatically needed to prevent and improve the recovery from myocardial ischemia reperfusion (I/R) injury. Direct interactions between mitochondria endoplasmic reticulum (ER) during heart diseases have been recently investigated. This study was designed explore cardioprotective effects of gypenoside XVII (GP-17) against I/R The roles ER stress, mitochondrial injury, their crosstalk within injury in GP-17-induced cardioprotection also explored.Cardiac contractility...
This study was designed to investigate the protective effects of didymin (Did) on doxorubicin (DOX)-induced cardiotoxicity.After pretreatment with Did (2, 4, 8 mg/kg intraperitoneal i.p.) for 7 d, male C57 mice were injected single dose DOX (20 i.p.). The cardioprotective effect observed 7th day after treatment.DOX delayed body growth and caused cardiac tissue injury, oxidative stress, mitochondrial dysfunction. Similar experiments in H9C2 cardiomyocytes showed that reduced cell viability,...
Clinical attempts to reduce the cardiotoxicity of arsenic trioxide (ATO) without compromising its anticancer activities remain be an unresolved issue. In this study, we determined whether Sal B can protect against ATO-induced cardiac toxicity in vivo and increase ATO toward cancer cells. Combination treatment was investigated using BALB/c mice human hepatoma (HepG2) cells cervical (HeLa) The results showed that combination significantly improved loss function, attenuated damage...
TAS attenuates LPS-induced cardiomyocyte dysfunction<italic>via</italic>down-regulation of inflammatory signaling in mice.
Aconite has the efficacy of reviving yang for resuscitation, dispelling cold and relieving pain, which is widely used in clinic, shows unique treating severe diseases. However, aconite great toxicity, with obvious cardio-toxicity neurotoxicity. Its toxicological mechanism main effect on voltage-dependent sodium channels, release neurotransmitters changes receptors, promotion lipid peroxidation cell apoptosis heart, liver other tissues. works to reduce toxicity mainly through compatibility...
Six novel flavonoid–triterpene saponin meroterpenoids, clinoposides A–F (<bold>1–6</bold>), with two unusual skeletons were isolated from <italic>Clinopodium chinense</italic>.
Left ventricular remodeling induced by myocardial ischemia/reperfusion injury (MI/RI) is a common cardiac dysfunction. Accumulating evidence has demonstrated that autophagy plays vital role in protecting against remodeling. This study aims to investigate the performance of compound Danshen Tablets (CDT) rescuing and whether as potential mechanism. The left anterior descending arteries rats were temporarily ligated for 30 min construct MI/RI model. Ventricular was reperfusion 28 d, during...