A5091801982- Thyroid Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Graphene and Nanomaterials Applications
- Genetic factors in colorectal cancer
- Graphene research and applications
- Ferroptosis and cancer prognosis
- Melanoma and MAPK Pathways
- S100 Proteins and Annexins
- Cutaneous Melanoma Detection and Management
- Laser-Ablation Synthesis of Nanoparticles
- Colorectal Cancer Treatments and Studies
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Clusterin in disease pathology
- Ovarian cancer diagnosis and treatment
- Respiratory and Cough-Related Research
- Nanoparticles: synthesis and applications
- Asthma and respiratory diseases
- Congenital heart defects research
- Ocular Oncology and Treatments
- Pituitary Gland Disorders and Treatments
- Renal and related cancers
- Biomarkers in Disease Mechanisms
- Renal cell carcinoma treatment
- Colorectal and Anal Carcinomas
Holy Cross University
2018-2024
Jagiellonian University
2016
Abstract Despite the introduction of new molecular classifications, advanced colorectal cancer (CRC) is treated with chemotherapy supplemented anti-EGFR and anti-VEGF targeted therapy. In this study, 552 CRC cases different primary tumor locations (250 left side, 190 rectum, 112 right side) were retrospectively analyzed by next generation sequencing for mutations in 50 genes. The most frequently mutated genes TP53 left-sided tumors compared to right-sided BRAF tumors. Mutations KRAS , NRAS...
In this study, we examined the relationship between coexisting BRAF V600E and TERT promoter mutations in papillary thyroid cancer (PTC) response to therapy. PTC cases (n = 568) with known status, diagnosed from 2000 2012 actively monitored at one institution, were reviewed retrospectively. Associations clinicopathological features, Tumor-Node-Metastasis stage, initial risk, therapy, follow-up, final disease outcome assessed according American Thyroid Association 2015 criteria Joint Committee...
This paper presents the results of interaction graphene oxide (GO) on MDA-MB-231 and SW-954 cancer cell lines. The tests were carried out in two variants. In first one, GO was sprayed a Petri dish then, lines cultured. second variant, cells covered with an aerosol containing GO. both variants, incubated tested every 24, 48, 72 h. After each time period, viability surface morphology measured. after h showed that coating caused reduction by 52.7% 26.4% for lines, respectively, respect to...
Background: The incidence of papillary thyroid cancer is increasing worldwide due to more frequent pathological detection microcarcinomas (PTMC), which are cancers measuring 1 cm or less in diameter. In rare cases, the course PTMC can be aggressive, with an increased risk recurrence/persistent disease. aim this study Polish patients diagnosed was assess impact concomitant B-type Raf kinas-activating mutation codon 600 exon 15 (BRAFV600E) and telomerase reverse transcriptase (TERT) hotspot...
Bronchial asthma is characterized by persistent airway inflammation and wall remodeling. Among many different cells growth factors triggering changes in bronchi structure, transforming factor β1-induced fibroblast to myofibroblast transition believed be very important. The aim of this study was evaluate whether theophylline (used therapy) two other methylxanthines (pentoxifylline its active metabolite lisofylline), may affect bronchial fibroblasts derived from asthmatic patients. We show...
Medullary thyroid cancer (MTC) is a rare malignancy that arises from calcitonin-producing C-cells. Curative treatment for patients with metastatic MTC challenging. Identifying the mechanisms by which cells inhibit activity of immune provides an opportunity to develop new therapies restore anticancer activity. Little known about immunological phenomena underlying MTC. Here, we examined expression profile 395 genes associated The study included 51 diagnosed at single center. Bioinformatical...
Ovarian cancer (OC) is the most lethal among gynecologic malignancies worldwide. Unfortunately, in around 70% of cases diagnosed late stages (III-IV) which decreases 5-year survival rate to 25%. The standard care ovarian debulking surgery followed by chemotherapy regimens based on platinum salts. Since 2014 PARP inhibitors became available for OC patients with germline or/and somatic mutations BRCA1/2, including maintenance therapy. BRCA1/2 Next Generation Sequencing (NGS)-based analysis...
In 2016, encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) was reclassified as noninvasive neoplasm with papillary-like nuclear features (NIFTP).In 2018 the criteria for NIFTP were widened by inclusion complete lack papillae.Secondary criteria, which include molecular examination, are helpful but not required diagnose.The aim this study to assess background and answer question if aplication revised diagnosis is associated oncogenic mutation.Repeat histopathological...
Medullary thyroid cancer (MTC) is a rare malignancy, and the treatment of metastatic MTC challenging. In previous work, immune profiling (RNA-Seq) identified CD276 as potential target for immunotherapy. expression was 3-fold higher in cells than normal tissues. Paraffin blocks from patients with were analyzed by immunohistochemistry to confirm results RNA-Seq. Serial sections incubated anti-CD276 antibody, scored according staining intensity percentage immunoreactive cells. The showed that...
Introduction: The noninvasive encapsulated, follicular variant of papillary thyroid carcinoma was reclassified as neoplasm with papillary-like nuclear features (NIFTP). exclusion NIFTP from the group malignant tumours decreases risk malignancy (RoM) defined by Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). aim present study to evaluate RoM each category in TBSRTC and without tally malignancies. Material methods: included 998 nodules cases. All patients underwent diagnostic...
Succinate dehydrogenase (SDH)-deficient renal cancer is a rare subtype recently accepted by the World Health Organization as unique of cell carcinoma (RCC). Here we report case 17-year-old man. The detailed evaluation indicated occurrence SDHB-deficient RCC. genetic testing revealed no germline mutation in SDH genes. Immunohistochemistry showed SDHB deficiency, overexpression pyruvate kinase M2 and dramatic downregulation fructose-1,6-bisphosphatase metabolic enzymes, unaltered levels...
Thyroid cancer (TC) is the most common of endocrine system. Most new diagnoses are low-grade papillary thyroid (PTC), suggesting that PTC may be over-diagnosed. However, incidence advanced-stage has increased in recent years. It therefore very important to identify prognostic factors for advanced PTC. Somatic mutation BRAF gene at V600E, or coexistence V600E and mutations TERT promoter associated with more aggressive disease. would also valuable genetic risk affecting prognosis. We evaluated...
The article presents application of microsieves made graphene paper for separation MDA-MB-231 breast cancer cells and SW-954 vulva cells. tests were carried out on a cell line grown under laboratory conditions. Holes in the sieves with laser ablation method. showed that analysed material is biocompatible aim both diagnosis circulating early identification disease conditions even at an stage its development.
Background: Multiple endocrine neoplasia type 2A (MEN2A) is a rare, hereditary syndrome resulting from germline mutation in the RET proto-oncogene and characterized primarily by medullary thyroid cancer (MTC), pheochromocytoma (PHEO), hyperparathyroidism. Types of have been associated with age at onset, clinical outcomes MTC, penetrance other components. Patients classified as ‘high-risk’ American Thyroid Association (ATA), based on aggressiveness MTC components, are recommended to undergo...
Abstract Despite the introduction of new molecular classifications, advanced colorectal cancer (CRC) is treated with chemotherapy supplemented anti-EGFR and anti-VEGF targeted therapy. In this study, 552 CRC cases different primary tumor locations (250 left side, 190 rectum, 112 right side) were retrospectively analyzed by next generation sequencing for mutations in 50 genes. The most frequently mutated genes TP53 left-sided tumors BRAF right-sided tumors. Mutations KRAS , NRAS not detected...