A5085146017- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Respiratory Support and Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Research Studies
- Ear and Head Tumors
- Pancreatic and Hepatic Oncology Research
- Congenital Diaphragmatic Hernia Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Nonmelanoma Skin Cancer Studies
- Nutrition and Health in Aging
- Cutaneous Melanoma Detection and Management
- Breast Cancer Treatment Studies
- Pleural and Pulmonary Diseases
- Colorectal Cancer Treatments and Studies
- Medical Imaging and Pathology Studies
- HER2/EGFR in Cancer Research
- Congenital Heart Disease Studies
- Nail Diseases and Treatments
- Renal cell carcinoma treatment
- Cancer Diagnosis and Treatment
- Breast Lesions and Carcinomas
Vrije Universiteit Amsterdam
2000-2023
National Institute of Mental Health and Neurosciences
2023
Amsterdam University Medical Centers
2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2007-2017
University Medical Center
1995-2016
University Hospital and Clinics
2016
University Hospitals of Leicester NHS Trust
2016
Rotterdam University of Applied Sciences
2000
University of Amsterdam
1994-1996
Atrium Health Wake Forest Baptist
1995
PURPOSE: Polymorphic epithelial mucin (PEM or MUC1) is being studied as a vaccine substrate for the immunotherapy of patients with adenocarcinoma. The present study analyzes incidence naturally occurring MUC1 antibodies in early breast cancer and relates presence these pretreatment serum to outcome disease. MATERIALS AND METHODS: We measured immunoglobulin G (IgG) M (IgM) an enzyme-linked immunoassay (PEM.CIg), which uses triple-tandem repeat peptide conjugated bovine albumin, samples...
A novel approach is described by which to identify the sentinel lymph node in patients with stage I melanoma. The technique involves a combination of intradermal patent blue V injection and gamma probe-assisted surgery. Eleven previously resected cutaneous melanoma, clinical (Breslow thickness 1.35-3.20 mm), underwent biopsy. Before surgery lymphoscintigraphy was performed evaluate pathways lymphatic drainage from site handheld probe used localize define exact incision. At same time,...
Abstract Background Axillary lymph node dissection is still performed as a staging procedure since status the most important prognostic factor in patients with breast cancer. Sentinel biopsy may replace routine axillary lymphadenectomy, especially small cancers. This study investigated whether ultrasonographically guided fine-needle aspiration cytology (FNAC) of nodes clinically node-negative was an accurate to select for sentinel biopsy. Methods One hundred and eighty-five consecutive were...
Our objective was to investigate effects of an oral nutritional supplement containing n-3 polyunsaturated fatty acids (FAs) on quality life, performance status, handgrip strength and physical activity in patients with non-small cell lung cancer (NSCLC) undergoing multimodality treatment. In a double-blind experiment, 40 stage III NSCLC were randomised receive 2 cans/day protein- energy-dense FAs (2.02 g eicosapentaenoic acid+0.92 docosahexaenoic acid/day) or isocaloric control supplement,...
Postoperative pulmonary complications are significant contributors to morbidity in patients who have undergone upper abdominal, thoracic, or cardiac surgery. The pathophysiology of these might involve postoperative inspiratory muscle weakness. nature weakness is unknown.To investigate the effect surgery on functioning diaphragm, main inspiration.Serial biopsies from diaphragm and latissimus dorsi were obtained 6 during thoracotomy for resection a tumor right lung. Biopsies taken as soon had...
Birt-Hogg-Dubé syndrome is an autosomal dominant disorder characterized by skin fibrofolliculomas, lung cysts, spontaneous pneumothorax and renal cell cancer due to germline folliculin (FLCN) mutations (Menko et al. in Lancet Oncol 10(12):1199-1206, 2009). The aim of this study was evaluate the incidence patients with BHD during or shortly after air travel diving.A questionnaire sent a cohort 190 medical files these were evaluated. diagnosis confirmed FLCN analysis all patients. We assessed...
Superior sulcus tumors (SSTs) are uncommon, and their anatomical location can make treatment challenging. We analyzed late outcomes of patients with SST treated concurrent chemoradiotherapy followed by surgical resection (trimodality) in a single tertiary institution.Patients non-small cell SSTs, who underwent trimodality therapy between 2002 2017, were selected from prospective institutional database. Patients uniformly staged 18F-fluorodeoxyglucose-positron emission tomography, computed...
Abstract The impact of intraoperative ultrasonography (IOUS) on treatment strategy was studied in 122 patients with primary colorectal cancer. All underwent preoperative liver imaging by and computed tomography (CT). After curative resection the tumour were eligible for adjuvant chemotherapy. findings IOUS assessed 6 months after laparotomy. Of 34 suspected metastases or CT, diagnosis confirmed 21. In remaining 13 suspect lesions shown to be benign. 88 normal results, detected five; four...
Recent studies proposed that mechanical inactivity of the human diaphragm during ventilation rapidly causes atrophy and weakness. However, conclusive evidence for notion weakness is a direct consequence lacking. To study effect hemidiaphragm paralysis on muscle fiber function structure in humans, biopsies were obtained from paralyzed eight patients with paralysis. All had unilateral known duration, caused by en bloc resection phrenic nerve tumor. Furthermore, three control subjects. The...
Paralysis of the diaphragm is an uncommon condition, which may result in dyspnoea on excertion and orthopnea. In patients who have symptoms, paralysed often plicated to prevent its paradoxical movement inspiration. This procedure brings relief many patients, but mechanism for this improvement not well understood.Nine symptomatic underwent plication a unilateral hemidiaphragm were prospectively evaluated. All pulmonary function tests cardiopulmonary exercise before surgery repeated them after...
Arthrographis kalrae is a rare isolate in clinical specimens. Only ten cases of infection with this species have been described so far. To our knowledge, we report the first case pulmonary caused by A. patient past history stage IIA Hodgkin's lymphoma and demonstrate that organism can act as an opportunistic human pathogen.
A simplified technique for iv infusion in unrestricted DBA/2J inbred mice has been described. The method, which involves direct cannulation of the tail vein with polyethylene tubing, is suitable routine use. Guanazole, an antileukemic agent a short plamsa half-life, was evaluated as model compound. After administration 47 hr at rate 0.3 ml/hr, guanazole (30 mg/ml) caused marked inhibition incorporation 14C-uridine, administered 15 min before sacrifice, primarily into DNA spleen, thymus and...
Wound complications following surgical resection in patients treated with neoadjuvant chemoradiation therapy are common and can be a difficult problem to manage. Negative pressure dressing technology appears safe effective the treatment of radiation-associated wound used outpatients clinic setting. The presented case demonstrates that negative also manages hydropneumothorax as result dehiscence thoracic wall.
Following trimodality treatment for superior sulcus tumours (SSTs), the 5-year survival rate has significantly improved. Quality of life and potential negative effects this strategy have become more important. The objective study was to investigate quality arm shoulder function after resection following neoadjuvant chemoradiation.Patients were selected from a thoracic surgery database. Between January 2002 December 2010, 72 patients received whom 39 alive at start in 2010. tests used:...