A5056621036- Pregnancy and preeclampsia studies
- Mesenchymal stem cell research
- Birth, Development, and Health
- MicroRNA in disease regulation
- Gestational Diabetes Research and Management
- Epigenetics and DNA Methylation
- Diabetes and associated disorders
- Angiogenesis and VEGF in Cancer
- Renal and related cancers
- Neuroscience and Neuropharmacology Research
- Cancer Risks and Factors
- Biochemical effects in animals
- Calpain Protease Function and Regulation
- Aldose Reductase and Taurine
- Nitric Oxide and Endothelin Effects
- Diabetes Treatment and Management
- Genetic Syndromes and Imprinting
- Sulfur Compounds in Biology
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Erythrocyte Function and Pathophysiology
- Cancer-related Molecular Pathways
- Glycosylation and Glycoproteins Research
- Wnt/β-catenin signaling in development and cancer
Akdeniz University
2012-2025
Akdeniz University Hospital
2011
Medical University of Graz
2005
University of Graz
2003
The endocannabinoid anandamide has been reported to affect neuronal cells, immune cells and smooth muscle via either CB1 or CB2 receptors. In endothelial the receptors involved in activating signal transduction are still unclear, despite fact that is produced this cell type. present study was designed explore detail effect of on Ca2+ signaling single a calf pulmonary line. Anandamide initiated transient elevation prevented by receptor antagonist SR144528, but not SR141716A. These data were...
<title>Abstract</title> Purpose Chronic glomerular and tubulointerstitial fibrosis is the leading cause of end-stage renal failure. Mesenchymal stem cell therapy shows great potential for kidney tissue regeneration. The use measurable biomarkers crucial assessing therapeutic effects mesenchymal cells. Adiponectin among suggested monitoring progression chronic Methods We extracted cells from amnion membrane term placentas. To establish experimental groups, we partially ligated left kidneys...
AbstractObjective. White blood cells are essential in mediating immune and inflammatory responses. A prominent feature of these during activation the function is increased glucose utilization, this dependent on functioning specific transporter (GLUT) isoforms. The few data available leukocyte expression limited to type‐2 diabetes mellitus, nothing known about its regulation. Material methods. Peripheral was drawn from 35 healthy controls diabetic subjects. Expression GLUT1, GLUT3 GLUT4...
The feature of chronic kidney failure (CKF) is loss functions due to erosion healthy tissue and fibrosis. Recent studies showed that Mesenchymal stem cells (MSCs) differentiated into tubular epithelial thus renal function structures renewed.Furthermore, MSCs protect in CKF. Therefore, we aimed investigate whether human amnion-derived mesenchymal (hAMSCs) can repair fibrosis determine the effects on proliferation apoptosis mechanisms failure.In this study, rat model CKF was constituted by...
Abstract: The GPI-anchored protein T-cadherin was found to be an atypical LDL binding site that is expressed in various types of cells, including endothelial smooth muscle and neurons. Notably, the expression reduced numerous cancers, although it up-regulated tumor-penetrating blood vessels, atherosclerotic lesions, during neointima formation. Despite these intriguing findings, our knowledge physiological role signal transduction pathways associated with this limited. Therefore,...
Diabetic pregnancy is associated with complications such as early and late embryonic death, fetal growth disorders, placental abnormalities, embryonal-placental metabolic disorders. Excessive apoptosis and/or changes of proliferation mechanisms are seen a major event in the pathogenesis diabetes-induced weight structural anomalies. Akt ERK1/2 proteins important for development cellular differentiation mechanisms. The mechanism underlying regulatory effects hyperglycemia have not been...
The placenta is a glucocorticoid target organ, and glucocorticoids (GCs) are essential for the development maturation of fetal organs. They widely used treatment variety diseases during pregnancy. In various tissues, GCs have regulated by glucose transport systems; however, their effects on transporters in human placental endothelial cells (HPECs) unknown. present study, HPECs were cultured 24 h presence or absence 0.5, 5 50 µmol · l(-1) synthetic GC triamcinolone (TA). carrier proteins GLUT...
The placenta is a temporary organ that provides communication between the mother and fetus. Maternal diabetes abnormal placental angiogenesis may be linked. We investigated mechanism resulting from VEGF glucose stimulation in PECs obtained human term placenta. Immunohistochemistry was performed to characterize D-glucose added medium containing establish normoglycemic hyperglycemic conditions. expression levels of VEGF, VEGFR-1 VEGFR-2 genes proteins control experimental groups were analyzed...
In various tissues, glucocorticoids (GCs) are known to downregulate glucose transport systems; however, their effects on transporters (GLUTs) in the placenta of a diabetic rat unknown. Glucocorticoid hormone action within cell is regulated by glucocorticoid receptor (GR). Thus, this study was designed investigate relationship between GR and transporter expression rat. Our immunohistochemical results indicated that protein 1 (GLUT 1) expressed ubiquitously trophoblast endothelial cells...
Glucocorticoids (GC) often are administered during pregnancy, but despite their widespread use in clinical practice, it remains uncertain how GC exposure affects pro-angiogenic factors and receptors. We investigated the effects of on vascular endothelial growth factor (VEGF), placental (PIGF), receptor 1 (VEGFR1) 2 (VEGFR2) protein mRNA expressions possible association with Akt/mTOR pathway. incubated human umbilical vein cells (HUVECs) a synthetic GC, triamcinolone acetonide (TA). TA...
Chronic kidney disease (CKD) is characterized by disruption of the glomerulus, tubule and vascular structures renal fibrosis. Mesenchymal stem cells (MSC) ameliorate CKD. We investigated effects human amnion derived MSC (hAMSC) on fibrosis using expression transforming growth factor beta (TGF-β), collagen type I (COL-1) bone morphogenetic protein (BMP-7). also levels urinary creatinine nitrogen in used a 5/6 nephrectomy (5/6 Nx) induced CKD model. 36 rats six groups animals: sham group, Nx...
Reduction of blood flow below a threshold value in brain regions locally or globally is called cerebral ischemia and proper treatment requires either the restoration normal and/or administration neuroprotective therapies. Human trophoblast progenitor cells (hTPCs) give rise to placenta are responsible for invasion vascular remodeling maternal vessels within uterus. Here, we tested whether hTPCs promoted differentiate along neural lineages may exhibit therapeutic properties setting...
Trophoblast stem cells develop from polar trophectoderm and give rise to the that generate placenta. are responsible for uterine invasion vascular remodeling during implantation of embryo. However this knowledge is not yet be confirmed trophoblast progenitor (TPCs). In study, we aimed demonstrate human TPCs (hTPCs) express release angiogenic factors first time. were isolated term Then immunophenotyping was performed by FACS method analyzing caudal type homeobox 2 (CDX2) eomesodermin (EOMES)....