A5033766135- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Myopathies and Dermatomyositis
- Lung Cancer Treatments and Mutations
- Vasculitis and related conditions
- Digestive system and related health
- RNA regulation and disease
- Cancer Genomics and Diagnostics
- Sarcoidosis and Beryllium Toxicity Research
- RNA Research and Splicing
- Pneumothorax, Barotrauma, Emphysema
- Gastric Cancer Management and Outcomes
- Eosinophilic Disorders and Syndromes
- Viral Infections and Immunology Research
- Cutaneous lymphoproliferative disorders research
- Adipose Tissue and Metabolism
- Skin Diseases and Diabetes
- Myasthenia Gravis and Thymoma
- Epigenetics and DNA Methylation
- Vascular Tumors and Angiosarcomas
- Meningioma and schwannoma management
- Pancreatic and Hepatic Oncology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Immunotherapy and Biomarkers
- Stress Responses and Cortisol
- Cancer-related molecular mechanisms research
National Hospital Organization Takasaki Medical Center
2021-2023
Gunma University
2019-2022
Fujieda Municipal General Hospital
2021
Tokushima University
2018
Institute of Biomedical Science
2018
Objectives Anti-melanoma differentiation-associated gene 5 (MDA5) autoantibody-positive and age at onset ≥60 years are poor prognosis factors in polymyositis (PM) dermatomyositis (DM) associated with interstitial lung disease (ILD) among Japanese patients. However, the influence of on clinical features anti-MDA5 patients DM remains unclear.Methods We retrospectively examined 40 autoantibodies according to age. compared aged <60 respect including laboratory test findings, high-resolution...
Transcribed-ultraconserved regions (T-UCRs), which contain conserved sequences with 100% identity across human, rat and mouse species, are a novel category of functional RNAs. The human transformer 2β gene (TRA2B) encodes UCR that spans exon 2 (276 bp) its neighboring introns. Among five spliced RNA variants (TRA2β1-5) transcribed from the TRA2B gene, only TRA2β4 contains 2. is overexpressed in colon cancer cells accelerates cell growth by blocking transcription CDKN1A. However, mechanisms...
A 67-year-old man with stage IV B lung adenocarcinoma was treated pembrolizumab. The patient admitted to the hospital because of influenza on day second cycle pembrolizumab treatment. He diagnosed pneumonia and antiviral drugs steroids. However, eventually died. In this case, treatment immune checkpoint inhibitors might have affected response caused by virus infection, that injury, which is an immune-related adverse event (irAE). Hence, it important that, caution should be taken prevent...
Geranylgeranylacetone (GGA) is a chaperon inducer that protects various types of cell and tissue against stress. We examined whether GGA modulated energy intake expenditure under stressful conditions. After mice were untreated or treated orally with (0.16 g per kg body weight day) for 10 days, they subjected to 2-h restraint stress once day 5 consecutive days. administration did not affect corticosterone response the Restraint rapidly decreased plasma leptin levels in control mice....
the She denied having ankle swelling chest trauma.However she was experiencing progressive worsening mMRC grade 2 dyspnoea.On admission tachypnoeic (32/min) and tachycardic (124/min).She not pale, febrile or cyanosed.Respiratory examination showed a AP1234
the past.She denied having orthopnoea, ankle swelling chest trauma.However she was experiencing progressive worsening mMRC grade 2 dyspnoea.On admission tachypnoeic (32/min) and tachycardic (124/min).She not pale, febrile or cyanosed.Respiratory examination showed a left deviated trachea with reduced expansion breath sounds on right hemi-thorax hyper resonance suggestive of sided pneumothorax without skin manifestation Tuberous Sclerosis.Results conclusion: Her CXR PA pneumothorax.HRCT...
Abstract Background: Circulating tumor DNA (ctDNA) provides molecular information on heterogeneity. Data regarding the predictive significance of ctDNA after first-line epidermal growth factor receptor ( EGFR ) tyrosine kinase inhibitors (TKIs) are limited. Thus, this study analyzed during osimertinib administration as a second-line or greater setting to examine association between mutation levels and clinical outcomes in patients with advanced non-small cell lung cancer (NSCLC). Methods:...
背景．胸腺癌は化学療法や放射線治療による治療効果が報告されているが，エビデンスは乏しい．今回我々は術後胸腔内再発に対し，放射線治療・逐次化学療法により長期無増悪生存が得られた症例を経験したので報告する．症例．55歳男性．胸腺癌に対して拡大胸腺摘出術＋リンパ節生検を施行した．術後6か月で右前胸部に再発を認めた．放射線治療を施行し，カルボプラチン・パクリタキセルによる化学療法を4コース施行し，完全寛解を得た．逐次放射線化学療法を施行後60か月再発はない．結語．本症例は，胸腺癌の再発症例に対して逐次放射線化学療法により5年無増悪生存が得られている貴重な症例と考えられた．