Sangilimuthu Alagar Yadav

ORCID: 0000-0003-0703-0408
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Research Areas
  • Phytochemicals and Antioxidant Activities
  • Phytochemistry and Biological Activities
  • Natural Antidiabetic Agents Studies
  • Protein Interaction Studies and Fluorescence Analysis
  • Essential Oils and Antimicrobial Activity
  • Computational Drug Discovery Methods
  • Drug Transport and Resistance Mechanisms
  • Garlic and Onion Studies
  • Pomegranate: compositions and health benefits
  • Enzyme Production and Characterization
  • Osteoarthritis Treatment and Mechanisms
  • Ethnobotanical and Medicinal Plants Studies
  • Nigella sativa pharmacological applications
  • Phytochemicals and Medicinal Plants
  • Pharmacogenetics and Drug Metabolism
  • Mesenchymal stem cell research
  • Heavy Metals in Plants
  • Phytochemical Studies and Bioactivities
  • Moringa oleifera research and applications
  • Synthesis and biological activity
  • Plant biochemistry and biosynthesis
  • Cancer therapeutics and mechanisms
  • Medicinal Plant Research
  • Nanoparticles: synthesis and applications
  • Psidium guajava Extracts and Applications

Karpagam Academy of Higher Education
2016-2025

Amrita Vishwa Vidyapeetham
2023

Bharathiar University
2011

Background: Essential oil components play an important role in food flavoring industries and chemical industries. from Pinus sylvestris (pine oil, scotch pine Turpentine Oil), Leucadendron argenteum (silver fir needle oil), Impatiens balsamina (balsam Abies sibirica (siberianfirn oil) contains numerous active ingredients that help to develop drug preparation. Objective: To compare the phytoconstituents present essential of (wood, cone, needle), (needle), (needle) (needle). Methods: This...

10.2174/0115734110355898250116025343 article EN Current Analytical Chemistry 2025-01-24

Fibrinolytic enzymes are produced by several Bacillus species. For the therapeutic purpose, fibrinolytic enzyme can be used as thrombolytic agent for clot resolution. In study, in modified nutrient medium under solid-state fermentation using pumilus strain-MPMBJ1 from CBNR isolate. The presence of media was confirmed salting-out methods conjunction with SDS-PAGE. purified dialysis method followed chromatographic technique. Biological activities were assessed through proteolytic and...

10.25303/203rjbt1680176 article EN Research Journal of Biotechnology 2025-01-31

Abstract Objective To evaluate the antioxidant activity of defatted methanol extract Barleria noctiflora (B. noctiflora) L.f. leaf and root using in vitro models. Methods DPPH radical scavenging activity, ferrous reducing power, Fe2+ chelating assay, nitric oxide ABTS·+ cation decolourisation superoxide anion hydrogen peroxide activities were studied. Results The extracts showed good capacity when compared to other models IC50 value found be 150 μg/mL 140 extract. total phenolic content...

10.1016/s2221-1691(12)60302-5 article EN Asian Pacific Journal of Tropical Biomedicine 2012-02-01

Background: Colon cancer is aggressive and it causes 0.5 million deaths per year. Practicing natural medicines for treatment safer than conventional drugs. World health organization emphasizes on the importance of practicing developing product based drugs treatment. Recently we reported an anti colon activity associated with pyrogallol isolated from medicinal plant Acacia nilotica in HT-29 cells vitro. To extend our observation this study evaluated vivo tumor remission property acetone...

10.31557/apjcp.2019.20.9.2645 article EN cc-by Asian Pacific Journal of Cancer Prevention 2019-09-01

Breast cancer is the world's second most frequent malignancy, with a significant mortality and morbidity rate. Nowadays, natural breast medicine has piqued attention as disease-curing agent low side effects. Herein, leaf powder of Artemisia absinthium was extracted ethanol, GC-MS LC-MS methods were employed to identify phytocompounds. Using commercial software SeeSAR-9.2 StarDrop, identified phytocompounds docked estrogen progesterone receptors they promote growth find binding affinity...

10.1080/07391102.2023.2212805 article EN Journal of Biomolecular Structure and Dynamics 2023-05-17

Abstract Background : Synthetic antihistamine drugs cause various adverse effects to overcome these problems with natural phytomedicine or phytoconstituents. Methods Tragia involucrata leaves were extracted soxhlet apparatus and fractionated column chromatography the homogenized fractions monitored thin layer (TLC) characterized by using UV-visible, FT-IR, 1 H NMR, 13 C NMR MS spectral studies. Isolated compounds screened their activity on ileum preparation, bronchoconstriction triple...

10.1515/jcim-2015-0015 article EN Journal of Complementary and Integrative Medicine 2015-06-04

Abstract Objectives Aqueous leaves extracts of Murraya koenigii (M. koenigii) and Aegle marmelos (A. marmelos) were prepared effect the on inhibiting alpha-amylase playing essential roles converting starch into glucose have been examined using in vitro assays. Methods Alpha amylase inhibitory assay was used to asses antidiabetic activity extracts. Gas chromatography-mass spectrometry (GC-MS) analysis performed identify volatile molecules Identified molecule converted as ligand docked against...

10.1515/jcim-2019-0345 article EN Journal of Complementary and Integrative Medicine 2020-08-03

Background Antioxidant and antihistamine agents from Barleria noctiflora L.f. as natural source due to the existing modern medicine give various adverse effects overcome these problems with products. MethodsB. leaves extract was fractionated column chromatography; homogenized fractions were monitored thin layer chromatography (TLC) characterized by using UV-visible, FT-IR, 1H NMR, 13C NMR mass spectrometry spectral studies. The volatile phytoconstituents of B. analysed gas...

10.1515/jcim-2015-0106 article EN Journal of Complementary and Integrative Medicine 2016-08-02

To compare the phytochemical and antimicrobial activity of Ethiopian Kale leaves infusions, investigate antioxidant profile major phytochemicals existing in better solvent system. were collected from Addis Ababa, Ethiopia, extracted using different solvents. The qualitative analysis, antibacterial assays, Fourier Transform Infrared (FTIR) analysis are executed for all extracts. Antioxidant assay Gas Chromatography-Mass Spectrometry (GC-MS) carried out system, which showed preliminary...

10.1016/j.chmed.2020.09.003 article EN Chinese Herbal Medicines 2020-11-14

Molecular docking analysis has shown to be an important tool for systematically harnessing natural pigment betanin's structural diversity. Natural betanin was used investigate its anticancer efficacy by in vitro cytotoxicity and cell cycle A549 lung cancer line. Furthermore, determine the promising molecular targets using different receptor proteins enzymes responsible DNA replication (DNA topoisomerases I II), (CDK-6), silico apoptotic markers (Bcl-2 caspase-3) Glide Schrodinger. In...

10.33263/briac123.31613172 article EN Biointerface Research in Applied Chemistry 2021-08-08

The calcium oxalate reduction capacity of Argemone mexicana was demonstrated in vivo ethylene glycol-induced urolithic rats. A. leaves extract at 400 and 750 mg kg−1 b.w. protection renal tubes, kidney cells reduced the levels serum creatinine compared to urolithiasis induced group. Further, restored blood urine markers normal before after treatment rats caused breakdown crystals urinary tract as observed by microscopy. protected from damage repaired increased diuresis activity thereby...

10.1080/10496475.2021.1891181 article EN Journal of Herbs Spices & Medicinal Plants 2021-03-09
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