A5071595967- Supramolecular Self-Assembly in Materials
- Tissue Engineering and Regenerative Medicine
- Immunotherapy and Immune Responses
- 3D Printing in Biomedical Research
- Hydrogels: synthesis, properties, applications
- Alzheimer's disease research and treatments
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Sperm and Testicular Function
- Connective tissue disorders research
- Advanced Electron Microscopy Techniques and Applications
- Photochromic and Fluorescence Chemistry
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Renal and related cancers
- Machine Learning in Bioinformatics
- Polydiacetylene-based materials and applications
- Reproductive Biology and Fertility
Washington University in St. Louis
2020-2024
Northwestern University
2016
Patterned substitution of d-amino acids into the primary sequences self-assembling peptides influences molecular-level packing and supramolecular morphology. We report that block heterochiral analogs model amphipathic peptide KFE8 (Ac-FKFEFKFE-NH
Synthetic peptides that self-assemble into cross-β fibrils are versatile building blocks for engineered biomaterials due to their modularity and biocompatibility, but structural morphological similarities amyloid species have been a long-standing concern translation. Further, polymorphs difficult characterize by using spectroscopic imaging techniques rely on ensemble averaging achieve high resolution. Here, we utilize Nile red (NR), an amyloidophilic fluorogenic probe, single-molecule...
Alginate hydrogels are widely used for tissue engineering and regenerative medicine due to their excellent biocompatibility. A facile commonly strategy crosslink alginate is the addition of Ca2+ that leads hydrogelation. However, extracellular a secondary messenger in activating inflammasome pathways following physical injury or pathogenic insult, which carries risk persistent inflammation scaffold rejection. Here, we present graft copolymers charge complementary heterodimeric coiled coil...
The suprastructural integrity of peptide self- assemblies is driven by an intricate array cohesive interactions that guide and maintain hierarchical order. Seemingly minor alterations to atomic arrangement, such as substitution with D- amino acids, can dramatically affect assembly potential resultant architecture. When a primary sequence comprised consecutive identical motifs, “block heterochiral” peptides be generated partitioning chiral inversions according these underlying elementary...
Currently approved replication-competent and inactivated vaccines are limited by excessive reactogenicity poor safety profiles, while subunit often insufficiently immunogenic without exogenous adjuvants. Self-assembling peptide-, peptidomimetic-, protein-based biomaterials offer a means to overcome these challenges through their inherent modularity, multivalency, biocompatibility. As scaffolds biologically derived present antigenic arrays reminiscent of natural viruses, they prone immune...
Abstract Synthetic peptides that self-assemble into cross-β fibrils have remarkable utility as engineered biomaterials due to their modularity and biocompatibility, but structural morphological similarity amyloid species has been a long-standing concern for translation. Further, polymorphs are difficult characterize using spectroscopic imaging techniques rely on ensemble averaging achieve high resolution. Here, we utilize single-molecule orientation-localization microscopy (SMOLM) formed by...
ABSTRACT Alginate hydrogels are widely used for tissue engineering and regenerative medicine due to their excellent biocompatibility. A facile commonly strategy crosslink alginate is the addition of Ca 2+ that leads hydrogelation. However, extracellular a secondary messenger in activating inflammasome pathways following physical injury or pathogenic insult leading persistent inflammation scaffold rejection. Here we present graft copolymers charge complementary heterodimeric coiled coil (CC)...