A5103268396- Hippo pathway signaling and YAP/TAZ
- Zebrafish Biomedical Research Applications
- MicroRNA in disease regulation
- Animal Genetics and Reproduction
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Cellular Mechanics and Interactions
- Retinal Development and Disorders
- Cancer-related molecular mechanisms research
- Congenital heart defects research
- Developmental Biology and Gene Regulation
Universidade Nova de Lisboa
2019-2022
University of Lisbon
2019-2022
Regeneration depends on the ability of mature cells at injury site to respond injury, generating tissue-specific progenitors that incorporate blastema and proliferate reconstitute original organ architecture. The metabolic microenvironment has been tightly connected cell function identity during development tumorigenesis. Yet, link between metabolism mechanistic level in a regenerative context remains unclear. adult zebrafish caudal fin, bone specifically, have crucial for understanding...
Osteoblast differentiation is a key process for bone homeostasis and repair. Multiple signalling pathways have been associated with osteoblast differentiation, yet much remains unknown on how this regulated in vivo Previous studies proposed that the Hippo pathway transcriptional co-activators YAP TAZ (also known as YAP1 WWTR1, respectively) maintain progenitor stemness inhibit terminal of osteoblasts, whereas others suggest they potentiate formation. Here, we use zebrafish caudal fin...
Vertebrates such as zebrafish have the outstanding ability to fully regenerate their retina upon injury, while mammals, including humans, do not. In zebrafish, light-induced photoreceptor regeneration is achieved through reprogramming of Müller glia cells, which proliferate and give rise a self-renewing population progenitors that migrate lesion site differentiate into new photoreceptors. The Hippo pathway effector YAP was recently implicated in response damage retina, but how this...
The shaping of bone structures relies on various cell types and signaling pathways. Here, we use the zebrafish bifurcating fin rays during regeneration to investigate patterning. We found that regenerating form via two mineralization fronts undergo an osteoblast-dependent fusion/stitching until branchpoint, bifurcation is not simply splitting one unit into two. identified tartrate-resistant acid phosphatase-positive osteolytic tubular at branchpoints, hereafter named tubules (OLTs). Chemical...
Tissue regeneration relies on precise molecular mechanisms controlling cell fate transitions, with metabolism emerging as a key regulator. Lactate-derived histone lactylation has recently been identified an important epigenetic modification involved in the regulation of gene expression across various biological processes. In this study, we report increase global and H3K18Lac levels mesenchyme osteoblasts zebrafish caudal fin, during early stages regeneration. Our findings demonstrate that is...
Abstract Regeneration depends on the ability of mature cells at injury site to respond injury, generating tissue-specific progenitors that incorporate blastema and proliferate reconstitute original organ architecture. The metabolic microenvironment has been tightly connected cell function identity during development tumorigenesis. Yet, link between metabolism mechanistic level in a regenerative context remains unclear. adult zebrafish caudal fin, bone specifically, have crucial for...