A5005662286- Neuropeptides and Animal Physiology
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
- Adenosine and Purinergic Signaling
- Receptor Mechanisms and Signaling
- RNA Research and Splicing
- HIV Research and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Apelin-related biomedical research
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Bioinformatics and Genomic Networks
- Inflammation biomarkers and pathways
- Protein Hydrolysis and Bioactive Peptides
- Autophagy in Disease and Therapy
- Advanced Drug Delivery Systems
- RNA regulation and disease
- Endoplasmic Reticulum Stress and Disease
University of Technology Sydney
2022-2024
L-Azetidine-2-carboxylic acid (AZE) is a non-protein amino that shares structural similarities with its proteogenic L-proline counterpart. For this reason, AZE can be misincorporated in place of L-proline, contributing to toxicity. In previous work, we have shown induces both polarization and apoptosis BV2 microglial cells. However, it still unknown if these detrimental effects involve endoplasmic reticulum (ER) stress whether co-administration prevents AZE-induced damage microglia. Here,...
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with strong neuroinflammatory component. Current treatments principally target immune but fail to preserve long-term myelin health and do not prevent neurological decline. Studies over past two decades have shown that structurally related neuropeptides VIP PACAP (vasoactive intestinal peptide pituitary adenylate cyclase-activating polypeptide, respectively) exhibit pronounced anti-inflammatory activities reduce...
Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are two neuroprotective anti-inflammatory molecules of the central nervous system (CNS). Both bind to three G protein-coupled receptors, namely PAC1, VPAC1 VPAC2, elicit their beneficial effects in various CNS diseases, including multiple sclerosis (MS). In this study, we assessed expression distribution PACAP/VIP receptors normal-appearing white matter (NAWM) MS donors with a clinical history...
Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most common and severe manifestations lupus; however, its pathogenesis still poorly understood. While there sparse evidence suggesting that ongoing autoimmunity may trigger pathogenic changes to central nervous system (CNS) microvasculature, culminating in inflammatory/ischemic damage, further needed. In this study, we used spontaneous mouse model SLE (NZBWF1 mice) investigate expression genes proteins associated with...