A5074679446- Hormonal and reproductive studies
- Muscle metabolism and nutrition
- Inhalation and Respiratory Drug Delivery
- Asthma and respiratory diseases
- Brain Metastases and Treatment
- Parathyroid Disorders and Treatments
- Magnesium in Health and Disease
- Biomedical Research and Pathophysiology
- Anesthesia and Pain Management
- Sexual function and dysfunction studies
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmaceutical studies and practices
- Hip and Femur Fractures
- Glioma Diagnosis and Treatment
- Pharmacological Effects and Assays
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Statistical Methods and Bayesian Inference
- Vitamin D Research Studies
- Ovarian function and disorders
- Body Composition Measurement Techniques
- Pharmacology and Obesity Treatment
- Heart Failure Treatment and Management
- Health Policy Implementation Science
University of Pennsylvania
2017-2023
Penn Presbyterian Medical Center
2023
Takeda (United States)
2013-2014
University Hospital Southampton NHS Foundation Trust
2012
Thomas Jefferson University
1997-1999
Philadelphia University
1999
Mercy Fitzgerald Hospital
1998
Mercy Medical Center
1998
Mercy Hospital
1998
Thomas Jefferson University Hospital
1998
Abstract Context Studies of the possible cardiovascular risk testosterone treatment are inconclusive. Objective To determine effect on biomarkers in older men with low testosterone. Design Double-blind, placebo-controlled trial. Setting Twelve academic medical centers United States. Participants In all, 788 ≥65 years old an average two serum levels <275 ng/dL who were enrolled The Testosterone Trials. Intervention gel, dose adjusted to maintain level normal range for young men, or...
High levels of circulating fibroblast growth factor 23 (FGF23) are associated with chronic kidney disease (CKD) progression and high mortality. In the Phosphate Reduction Evaluation FGF23 in Early CKD Treatment (PREFECT) study, we assessed effect reducing intestinal phosphate absorption using lanthanum carbonate on normophosphatemic patients stage 3. Thirty-five individuals were randomized to 3000 mg/day (n = 23) or placebo 12) for 12 weeks. Levels intact (iFGF23), C-terminal FGF23, serum...
Abstract Context Prostate-specific antigen (PSA) changes during testosterone treatment of older hypogonadal men have not been rigorously evaluated. Design Double-blinded, placebo-controlled trial. Setting Twelve US academic medical centers. Participants Seven hundred ninety ≥65 years age with average levels ≤275 ng/dL. Men at high risk for prostate cancer were excluded. Interventions Testosterone or placebo gel 12 months. Main Outcomes Percentile in PSA Results that increased from 232 ± 63...
Postoperative radiotherapy for low-grade gliomas has been shown in retrospective series to improve survival, compared with surgery alone. To determine the proper treatment volume and dose, an understanding of patterns failure current techniques is necessary. We studied 30 consecutive patients who had a pathologic diagnosis nonpilocytic glioma treated our department between 1975 1994. Before radiotherapy, 5 underwent biopsy, 22 subtotal resection, 3 gross total excision. All pre-...
In clinical practice, α2-adrenoceptor agonists have been adjunctively administered with psychostimulants for the treatment of attention-deficit/hyperactivity disorder (ADHD). Two studies examined adjunctive use guanfacine extended release (GXR, Intuniv®; Shire Development LLC, Wayne, PA, USA) in children and adolescents a suboptimal response to psychostimulant treatment. However, potential pharmacokinetic drug–drug interactions (DDIs) between GXR lisdexamfetamine dimesylate (LDX, Vyvanse®;...
A new species overlap measure is defined as the probability that, given a randomly selected present in at least one of two communities, it both communities. This can be thought community analog Jaccard index for between samples. Standard maximum likelihood methods are used to estimate parameters modified beta-binomial' distribution. leads directly estimates measure. In an example from decapod communities on coral reefs, shown that this 50% larger than commonly overlap.
Background: MMX ® mesalamine is a once daily oral 5-aminosalicylic acid formulation, effective in induction and maintenance of ulcerative colitis remission. Patients on long-term may occasionally require concomitant antibiotic treatment for unrelated infections. Aim: To evaluate the potential pharmacokinetic interactions between amoxicillin, ciprofloxacin extended release (XR), metronidazole, or sulfamethoxazole four open-label, randomized, placebo-controlled, two-period crossover studies....
Group sequential methods to allow the possibility of early termination a trial due sufficiently convincing results are standard in therapeutic clinical trials but have been little considered bioequivalence trials. We investigate statistical properties one group approach In particular, we interested maintenance level (5%), quantification any loss power, and probability stopping. These assessed via data simulated according pharmacokinetic model. find that there cases where has substantial...
After colectomy, continent ileal reservoirs are an accepted alternative to conventional ileostomy for patients with ulcerative colitis. To assess the effect of these on digestive function, circulating and morphologic gut endocrine responses were measured in a or pelvic pouch compared ileostomy, active colitis healthy controls. Eight subjects studied each group. Basal postprandial plasma gastrin, enteroglucagon, neurotensin, vasoactive intestinal polypeptide, insulin, pancreatic glucagon,...
Platelets play a central role in atherothrombotic events. We investigated the effect of novel platelet-lowering agent, rafigrelide, on thrombus formation and characteristics. In this phase 1, open-label, non-randomised, single-sequence, crossover study, healthy male volunteers received rafigrelide for 14 days (Period 1). Following ≥6-week washout period, they then + acetylsalicylic acid (ASA) 2). Thrombus was assessed ex vivo using Badimon perfusion chamber, characteristics were...
Abstract Objective Recent results from the Cardiovascular Trial of Testosterone Trials showed that testosterone treatment older men with low was associated greater progression noncalcified plaque (NCP). We evaluated effect anthropometric measures and cardiovascular biomarkers on in individuals Trial. Methods The part trial included 170 aged 65 years or testosterone. Participants received gel placebo for 12 months. primary outcome change NCP volume baseline to months, as determined by...
This investigation evaluated the iron and nutritional status of 12 highly trained aerobic dance instructors who did not take supplements (ANS) 8 (AS). A control group (C) consisted 10 age matched controls. The had exercised for approximately 3.8 days/wk, 56 min/session past 7 yrs. There were no significant differences among groups energy intake, carbohydrate, protein, fat, nonheme iron, heme or total intake (excluding supplemental iron). But both exercise lower ferritin values than group....
BACKGROUND/OBJECTIVES Accurate estimates of clinically important difference (CID) are required for interpreting the clinical importance treatments to improve physical function, but CID vary in different disease populations. We determined two common measures walking ability mobility‐limited older men. Design Longitudinal, multisite placebo‐controlled trial. Setting/Participants Men enrolled Testosterone Trials who had self‐reported mobility limitation and gait speed less than 1.2 m/second (n...
<h3>Introduction and Objectives</h3> In 2009/10 there were 1.5 million hospital admissions in adults aged >35yrs with a smoking related illness. Smoking cessation is cost effective clinical intervention, producing better health outcomes for patients saving NHS resources. 2010/11 total expenditure on ‘NHS Stop Services’ England excluding prescriptions was £84.3million. NICE guidelines recommend that every smoker should be offered advice prescription of nicotine replacement therapy (NRT)....