Daan van Wessel
A5029369207- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- HIV-related health complications and treatments
- Congenital Anomalies and Fetal Surgery
- Drug Transport and Resistance Mechanisms
- Intestinal Malrotation and Obstruction Disorders
- Neonatal Health and Biochemistry
- Folate and B Vitamins Research
- Nutrition and Health in Aging
- Metabolism and Genetic Disorders
- Gastroesophageal reflux and treatments
- Immunodeficiency and Autoimmune Disorders
- Liver Disease Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- HIV/AIDS oral health manifestations
- Body Composition Measurement Techniques
- Nutrition, Genetics, and Disease
- Clinical Nutrition and Gastroenterology
- Pharmacological Effects and Toxicity Studies
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Recycling and Waste Management Techniques
- Liver Disease and Transplantation
- Genetics and Neurodevelopmental Disorders
- Pancreatitis Pathology and Treatment
University of Groningen
2017-2022
University Medical Center Groningen
2017-2022
University of Ottawa
2022
Children's Hospital of Eastern Ontario
2022
Pediatrics and Genetics
2021
Zambon (Netherlands)
2020
University of Cologne
1994
Mutations in ATPase phospholipid transporting 8B1 (ATP8B1) can lead to familial intrahepatic cholestasis type 1 (FIC1) deficiency, or progressive 1. The rarity of FIC1 deficiency has largely prevented a detailed analysis its natural history, effects predicted protein truncating mutations (PPTMs), and possible associations serum bile acid (sBA) concentrations surgical biliary diversion (SBD) with long-term outcome. We aimed provide insights by using the largest genetically defined cohort...
These case studies review the treatment of patients with overactive bladder (OAB), a chronic condition presenting urinary urgency, often occurring frequency and nocturia, which may or not be associated incontinence. Patients OAB can have multiple clinical factors to consider when selecting optimal therapy, this series provides examples approaches balance selection other comorbidities patient expectations.
Biliary atresia (BA) occurs in 0.54 of 10.000 overall live births the Netherlands. BA has an unfavorable prognosis: <40% patients are cleared jaundice after Kasai portoenterostomy (KPE), 4-year transplant-free survival rate is 46% and ∼75%. Little known on difficulties diagnosis outcome preterm infants. We aimed to analyze incidence infants Netherlands.Retrospective study including Dutch treated for BA. Parameters included gestational age, congenital anomalies, age at KPE, days between first...
The aim of the study is to determine prognosis patients with biliary atresia after 2 years native liver survival (NLS) and identify prognostic factors for continued NLS age.We retrospectively analyzed perioperative, laboratory, outcome parameters all in Netherlands between January 1987 June 2015 at least years. We compared who have their (NLS+) those did not, either by transplant or death (NLS-).We included 100 patients. Upon a median follow-up 16.4 years, ended 37% transplantation (LTx) 6%...
ABSTRACT Background and Aims: Biliary atresia (BA) is a cholestatic, fibro-obliterative cholangiopathy of unknown etiology. BA primarily treated by surgical approach, that is, the Kasai portoenterostomy (KPE), to obtain clearance jaundice (COJ). The gut microbiota (GM) composition has been associated with course several cholestatic liver diseases. It largely unknown, however, whether GM associates outcome KPE. We compared patients controls assessed if before KPE was related COJ after...
Portal hypertension often occurs in biliary atresia (BA). The subsequent development of esophageal varices and bleeding from these are a well-known complication. We aim to describe the incidence severity variceal patients with BA. In addition, we characteristics who experienced bleeds. included all infants treated for BA at our center between March 1987 August 2015. Variceal was defined as hematemesis and/or melena presence endoscopy. Findings endoscopy ultrasound, laboratory tests,...
Environmental factors may be involved in the pathogenesis of biliary atresia (BA). This epidemiological study aimed to analyze relationships between incidence BA, confirmed viral or bacterial infections and population density, geographical temporal clustering BA Netherlands.Correlations monthly number were assessed. per province was calculated compared with highest density. Birthplaces classified as rural urban. Temporal month birth conception analyzed. We performed analyses for isolated...
Genotype-phenotype relationships of truncating mutations, p.E297G and p.D482G in