A5047986944- Ion Transport and Channel Regulation
- Electrolyte and hormonal disorders
- Otitis Media and Relapsing Polychondritis
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Lung Cancer Treatments and Mutations
- Biomedical and Chemical Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hepatitis C virus research
- Cancer Immunotherapy and Biomarkers
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal function and acid-base balance
Chubu Rosai Hospital
2023-2025
<sec> <title>BACKGROUND</title> Rheumatoid arthritis (RA) is a global health concern with increasing prevalence. Despite recommendations for regular disease activity assessments, their implementation in routine clinical practice remains challenging. </sec> <title>OBJECTIVE</title> This study evaluated the association between of Medical Support System Arthritis (MiRAi), an automated tool integrated electronic records that calculates Disease Activity Rating Index RA, and frequency assessments...
Objective Tocilizumab (TCZ) is effective for giant cell arteritis (GCA). However, little known regarding treatment modification and clinical outcomes after unfavorable events such as GCA relapses or TCZ discontinuation due to adverse (AEs). Methods This multicenter retrospective study included patients with who initiated from 2008 2021 at 5 Japanese hospitals. TCZ-related AEs were monitored 2 years initiation. In relapses, subsequent courses, including relapse symptoms modification, followed...
Severe hyponatremia can cause life-threatening cerebral edema. Treatment comprises rapid elevation of serum sodium concentration; however, overcorrection result in osmotic demyelination. This study investigated potential factors, including predictive correction based on the Edelman equation, associated with appropriate 221 patients a concentration ≤ 120 mEq/L who were admitted to hospital Nagoya, Japan. Appropriate was defined as an range 4-10 first 24 h and within 18 48 after start...
A Japanese woman in her 60s developed a kidney injury 9 weeks after treatment with pemetrexed, carboplatin, and pembrolizumab for stage IV lung adenocarcinoma. renal biopsy showed chronic tubulointerstitial damage minimal focal interstitial inflammation, consistent pemetrexed-induced nephropathy; thus, pemetrexed was withdrawn. However, the continued to worsen. repeated severe acute nephritis, suggestive of pembrolizumab-induced immune-related adverse event (irAE). The worsening...
Key Points Water diuresis presents a conundrum during the treatment of profound hyponatremia, but its clinical characteristics remain unclear. This study revealed that water mostly manifests within 24 hours treatment, preceded by changes in urinary characteristics. Careful urine monitoring early stages hyponatremia could facilitate detection diuresis. Background Hyponatremia guidelines recommend avoiding excessive increases serum sodium concentration (s[Na]) to prevent osmotic demyelination...
The optimal treatment for profound hyponatraemia remains uncertain. Recent clinical studies have demonstrated that a standardized bolus of hypertonic saline is effective, but relying solely on this approach may not fully address the individual variability among patients. We evaluated effectiveness rapid (RB) administration followed by predictive correction (PC) using an infusate and fluid loss formula identical to Barsoum-Levine based Edelman equation (RB-PC) managing hyponatraemia. In...