A5012081901- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
Chengdu Medical College
2021-2025
Axons of dopaminergic neurons projecting from substantia nigra to striatum are severely affected in the early stage Parkinson's disease (PD), with axonal degeneration preceding loss cell bodies. Our previous study indicated that dysfunctional retrograde transport could lead death resulting PD (10.1111/j.1471-4159.2008.05526.x). However, dynein, as main molecule involved transport, was not affected. This aimed verify hypothesis dynactin rather than dynein may be one key factors PD. Dynactin...
Minichromosome maintenance protein 5 (MCM5), a member of the microchromosomal family, plays an important role in initiation and extension DNA replication. However, its neural development zebrafish remains unclear. Here, we used morpholino (MO) CRISPR/Cas9 to knock down <i>mcm5</i> investigated developmental features facial motor neurons (FMNs) hindbrain zebrafish. We found that knockdown using MO resulted small head, eyes, blurred midbrain-hindbrain boundary, while injection led...