A5078471632- Plant Stress Responses and Tolerance
- Genetics, Aging, and Longevity in Model Organisms
- Genomics, phytochemicals, and oxidative stress
- Monoclonal and Polyclonal Antibodies Research
- Protein Interaction Studies and Fluorescence Analysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pharmaceutical and Antibiotic Environmental Impacts
- Drug Transport and Resistance Mechanisms
- Antibiotic Resistance in Bacteria
Universitat de Barcelona
2021
Institut d'Investigació Biomédica de Bellvitge
2020
Institut Català d'Oncologia
2020
The interaction between drugs and transport proteins, such as albumins, is a key factor in drug bioavailability. One of the techniques commonly used for evaluation drug-protein complex formation fluorescence. This work studies human serum albumin (HSA) with four non-steroidal anti-inflammatory (NSAIDs)—ibuprofen, flurbiprofen, naproxen, diflunisal—by monitoring fluorescence quenching when drug-albumin formed. Two approaches—the double logarithm Stern-Volmer equation STAR program—are to...
Abstract Mammalian IκB proteins (IκBs) exert their main function as negative regulators of NF-κB, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for IκBs has been shown to affect stemness cell differentiation. However, the involvement NF-κB in this not excluded. NFKI-1 IKB-1 are homologs Caenorhabditis elegans , which lacks nuclear effectors. We found that nfki-1 ikb-1 mutants display developmental defects phenocopy mutations Polycomb UTX-1...
This work reports a detailed characterization of the antimicrobial profile two trimethoprim-like molecules (compounds 1a and 1b) identified in previous studies. Both displayed remarkable activity, particularly when combined with sulfamethoxazole. In disk diffusion assays on Petri dishes, compounds 1b showed synergistic effects colistin. Specifically, combinations low concentrations colistin, very large increases activities were determined, as demonstrated by alterations kinetics bacterial...
Summary Mammalian IκB proteins (IκBs) exert their main function as negative regulators of NF-κB, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for IκBs has been shown to affect stemness cell differentiation. However, the involvement NF-κB in this not excluded. NFKI-1 IKB-1 are homologs Caenorhabditis elegans , which lacks nuclear effectors. We found that nfki-1 ikb-1 mutants display developmental defects phenocopy mutations Polycomb UTX-1...