Objectives Kidney diseases significantly impact individuals' quality of life and strongly reduce expectancy. Glomeruli play a crucial role in kidney function. Current imaging techniques cannot visualize them due to their small size. Sensing ultrasound localization microscopy (sULM) has shown promising results for visualizing vivo the glomeruli human grafts. This study aimed evaluate ability sULM native kidneys despite depth shorter duration acquisition limited by period patient's apnea....

Glomeruli are the filtration units of kidney and their function relies heavily on microcirculation. Despite its obvious diagnostic importance, an accurate estimation blood flow in capillary bundle within glomeruli defies resolution conventional imaging modalities. Ultrasound Localization Microscopy (ULM) has demonstrated ability to image in-vivo deep organs body. Recently, concept sensing ULM or sULM was introduced classify individual microbubble behavior based expected physiological...

Background: Deep brain structures are supplied by perforating arteries, which too thin to be observed with non-invasive and widely available clinical imaging methods. In moyamoya disease, main arteries in the base of progressively narrow, grow densely tortuously compensate lack blood supply deep structures. Purpose: The aim this study is evaluate efficacy transcranial ultrasound localization microscopy (ULM) visualizing utilizing a standard low-frame-rate scanner contrast sequences commonly...

Using microbubbles coated by a thin shell as ultrasound contrast agents for diagnosis improves image resolution. Since numerous are used in clinical practice, understanding the acoustic properties of liquids containing multiple is important. However, interactions between and have not been fully investigated theoretically. Additionally, with shells made various materials developed. Recently, an equation motion that considers anisotropy was proposed [Chabouh et al., “Spherical oscillations...

Systemic injection of thrombolytic drugs is the gold standard treatment for non-invasive blood clot resolution. The most serious risks associated with intravenous tissue plasminogen activator-like proteins are bleeding complication and dose related neurotoxicity. Indeed, drug has to be injected in high concentrations due its short half-life, presence natural inhibitor (PAI-1) fast hepatic clearance (0.9 mg/kg humans, 10 mouse models). Overall, there a need dose-reduced targeted overcome...

<title>Abstract</title> We present an open-source code for 3D super-resolution ultrasound imaging. Open-3DULM was applied to transcranial imaging in habituated awake mice. Comparative analysis reveals that isoflurane anesthesia induces significant vasodilation and higher cerebral blood flow compared the state. This method could serve as a reference developing new types of vascular quantifications, particularly emphasizing importance accurate measurement neuroscience research.

Abstract Engineered microswimmers show great promise in various biomedical applications. However, their application is hindered by the slow mobility, limited maneuverability and poor biocompatibility. Lipid coated microbubbles have high compressibility are already approved for clinical use as diagnostic ultrasound contrast agents. Here we experimentally investigate swimming motion of these under external cyclic overpressure. A net displacement was generated via reproducible non-destructive...

In Ultrasound Localization Microscopy (ULM), achieving high-resolution images relies on the precise localization of contrast agent particles across a series beamformed frames. However, our study uncovers an enormous potential: The process delay-and-sum beamforming leads to irreversible reduction Radio-Frequency (RF) channel data, while its implications for remain largely unexplored. rich contextual information embedded within RF wavefronts, including their hyperbolic shape and phase, offers...

Glomeruli are the filtration units of kidney and their function relies heavily on microcirculation. Despite its obvious diagnostic importance, an accurate estimation blood flow in capillary bundle within glomeruli defies resolution conventional imaging modalities. Ultrasound Localization Microscopy (ULM) has demonstrated ability to image in-vivo deep organs body. Recently, concept sensing ULM or sULM was introduced classify individual microbubble behavior based expected physiological...

Ultrasound Localization Microscopy (ULM) enables imaging of vascular structures in the micrometer range by accumulating contrast agent particle locations over time. Precise and efficient target localization accuracy remains an active research topic ULM field to further push boundaries this promising medical technology. Existing work incorporates Delay-And-Sum (DAS) beamforming into pipelines, which ultimately determines image resolution capability. In paper we propose feed unprocessed...

ABSTRACT Ultrasound Localization Microscopy (ULM) has been applied in various preclinical settings and the clinic to reveal microvasculature deep organs. However, most ULM images employ standard Delay-and-Sum (DAS) beamforming. In conditions, lengthy acquisition times are required fully reconstruct small vessels due need for spatially isolated microbubbles, resulting low temporal resolution. When microbubbles densely packed, localizing a point spread function with significant main side lobes...

Abstract Background Deep brain structures are supplied by perforating arteries, these arteries too thin to be observed with non-invasive and widely available clinical imaging methods. In Moya disease, main in the base of progressively narrowed, grow densely tortuously compensate lack blood supply deep structures. Purpose The aim this study is evaluate efficacy transcranial ultrasound localization microscopy (ULM) visualizing utilizing a standard low-frame-rate scanner contrast sequences...

Rationale: Renal pseudotumors, which mimic tumors on imaging, pose diagnostic challenges that can lead to unnecessary interventions. Sensing ultrasound localization microscopy (sULM) is an advanced imaging technique uses and microbubbles as sensors visualize kidney functional units. This study aims investigate whether sULM could differentiate between renal pseudotumors based the presence of glomeruli. Methods: Eleven patients (6 tumors, 6 - 1 patient with 2 pseudotumors) were included. Data...

Abstract Cleverly engineered microswimmers show great promise in various biomedical applications. Current realizations are generally either too slow, hardly manoeuvrable, or non biocompatible. To overcome these limitations, we consider lipid coated microbubbles that already approved for clinical use as diagnostic ultrasound contrast agents. Through a combination of experiments and numerical simulations, investigate the swimming motion under external cyclic overpressure. Reproducible...

In Ultrasound Localization Microscopy (ULM), achieving high-resolution images relies on the precise localization of contrast agent particles across a series beamformed frames. However, our study uncovers an enormous potential: The process delay-and-sum beamforming leads to irreversible reduction Radio-Frequency (RF) channel data, while its implications for remain largely unexplored. rich contextual information embedded within RF wavefronts, including their hyperbolic shape and phase, offers...

Ultrasound Localization Microscopy (ULM) enables imaging of vascular structures in the micrometer range by accumulating contrast agent particle locations over time. Precise and efficient target localization accuracy remains an active research topic ULM field to further push boundaries this promising medical technology. Existing work incorporates Delay-And-Sum (DAS) beamforming into pipelines, which ultimately determines image resolution capability. In paper we propose feed unprocessed...